The role of genetic polymorphisms in the thymidylate synthase (TYMS) gene in methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia

OBJECTIVEMethotrexate (MTX) is an important drug in the treatment of pediatric acute lymphoblastic leukemia (ALL). MTX is cytotoxic as it impairs DNA and RNA synthesis by inhibiting the enzymes dihydrofolate reductase (DHFR) and thymidylate synthase (TYMS). The association between genetic variants w...

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Veröffentlicht in:	Pharmacogenetics and genomics 2018-10, Vol.28 (10), p.223-229
Hauptverfasser:	Oosterom, Natanja, Berrevoets, Marijn, den Hoed, Marissa A.H, Zolk, Oliver, Hoerning, Susanne, Pluijm, Saskia M.F, Pieters, Rob, de Jonge, Robert, Tissing, Wim J.E, van den Heuvel-Eibrink, Marry M, Heil, Sandra G
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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