Pharmacokinetic and Pharmacodynamic Interaction Between Tolvaptan, a Non-Peptide AVP Antagonist, and Furosemide or Hydrochlorothiazide

The pharmacokinetic and pharmacodynamic interactions between tolvaptan and furosemide or hydrochlorothiazide (HCTZ) were determined in a single-center, randomized, open-label, parallel-arm, 3-period crossover study conducted in healthy white (Caucasian) men. A total of 12 subjects were enrolled in t...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 2007-08, Vol.50 (2), p.213-222
Hauptverfasser:	Shoaf, Susan E, Bramer, Steven L, Bricmont, Patricia, Zimmer, Christopher A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antidiuretic Hormone Receptor Antagonists Arginine Vasopressin - blood Arginine Vasopressin - drug effects Benzazepines - adverse effects Benzazepines - pharmacokinetics Benzazepines - pharmacology Cross-Over Studies Diuretics - adverse effects Diuretics - pharmacokinetics Diuretics - pharmacology Drug Interactions Furosemide - adverse effects Furosemide - pharmacokinetics Furosemide - pharmacology Humans Hydrochlorothiazide - adverse effects Hydrochlorothiazide - pharmacokinetics Hydrochlorothiazide - pharmacology Male Osmolar Concentration Renin - blood Renin - drug effects Sodium - blood
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