Combined neoadjuvant chemotherapy with bevacizumab improves pathologic complete response in patients with hormone receptor negative operable or locally advanced breast cancer

To evaluate the pathologic complete response (pCR) and safety of bevacizumab (B) with chemotherapy in the neoadjuvant setting of breast cancer (BC). A prospective single-arm, single-institution phase II trial for women with stage IIA-B/IIIA-B-C BC. Patients received neoadjuvant docetaxel, cyclophosp...

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Veröffentlicht in:	American journal of clinical oncology 2015-02, Vol.38 (1), p.74-79
Hauptverfasser:	Makhoul, Issam, Klimberg, Vicki Suzanne, Korourian, Soheila, Henry-Tillman, Ronda S, Siegel, Eric R, Westbrook, Kent C, Hutchins, Laura F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult African Americans Aged Angiogenesis Inhibitors - administration & dosage Antibodies, Monoclonal, Humanized - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bevacizumab Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinoma - drug therapy Carcinoma - metabolism Carcinoma - pathology Carcinoma, Ductal, Breast - drug therapy Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - pathology Carcinoma, Lobular - drug therapy Carcinoma, Lobular - metabolism Carcinoma, Lobular - pathology Cyclophosphamide - administration & dosage European Continental Ancestry Group Female Humans Lymph Nodes - pathology Mastectomy Mastectomy, Segmental Middle Aged Neoadjuvant Therapy Neoplasm Staging Prospective Studies Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Retrospective Studies Taxoids - administration & dosage Treatment Outcome Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - pathology
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