Paclitaxel poliglumex, temozolomide, and radiation for newly diagnosed high-grade glioma: a Brown University Oncology Group Study

Paclitaxel poliglumex (PPX), a drug conjugate that links paclitaxel to poly-L-glutamic acid, is a potent radiation sensitizer. Prior studies in esophageal cancer have demonstrated that PPX (50 mg/m/wk) can be administered with concurrent radiation with acceptable toxicity. The primary objective of t...

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Veröffentlicht in:	American journal of clinical oncology 2014-10, Vol.37 (5), p.444-449
Hauptverfasser:	Jeyapalan, Suriya, Boxerman, Jerrold, Donahue, John, Goldman, Marc, Kinsella, Timothy, Dipetrillo, Thomas, Evans, Devon, Elinzano, Heinrich, Constantinou, Maria, Stopa, Edward, Puthawala, Yakub, Cielo, Deus, Santaniello, Alyson, Oyelese, Adetokunbo, Mantripragada, Kalyan, Rosati, Kayla, Isdale, Debora, Safran, Howard
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Brachytherapy Brain Neoplasms - mortality Brain Neoplasms - therapy Chemoradiotherapy - methods Combined Modality Therapy Dacarbazine - administration & dosage Dacarbazine - analogs & derivatives Disease-Free Survival Female Glioma - mortality Glioma - therapy Humans Male Middle Aged Paclitaxel - administration & dosage Paclitaxel - analogs & derivatives Polyglutamic Acid - administration & dosage Polyglutamic Acid - analogs & derivatives Survival Analysis
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