Preoperative capecitabine and accelerated intensity-modulated radiotherapy in locally advanced rectal cancer: a phase II trial

A prospective phase II trial was conducted to evaluate the feasibility, safety, and pathologic response rate of preoperative capecitabine and accelerated synchronous integrated boost (SIB) intensity-modulated radiotherapy (IMRT) in patients with locally advanced rectal cancer. Consenting operable pa...

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Veröffentlicht in:	American journal of clinical oncology 2008-06, Vol.31 (3), p.264-270
Hauptverfasser:	Ballonoff, Ari, Kavanagh, Brian, McCarter, Martin, Kane, Madeleine, Pearlman, Nathan, Nash, Russell, Shah, Raj J, Raben, David, Schefter, Tracey E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - pathology Adenocarcinoma - surgery Adenocarcinoma - therapy Aged Antimetabolites, Antineoplastic - administration & dosage Capecitabine Chemotherapy, Adjuvant Deoxycytidine - administration & dosage Deoxycytidine - adverse effects Deoxycytidine - analogs & derivatives Diarrhea - chemically induced Disease-Free Survival Feasibility Studies Fluorouracil - administration & dosage Fluorouracil - adverse effects Fluorouracil - analogs & derivatives Humans Male Middle Aged Neoplasm Staging Premedication Prospective Studies Radiotherapy Dosage Radiotherapy, Adjuvant Radiotherapy, Intensity-Modulated Rectal Neoplasms - pathology Rectal Neoplasms - surgery Rectal Neoplasms - therapy Remission Induction
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