Therapeutic (High) Doses of Rituximab Activate Calcium Mobilization and Inhibit B-cell Growth via an Unusual Mechanism Triggered Independently of Both CD20 and Fcγ Receptors

Rituximab is a CD20-specific monoclonal antibody that effectively targets and depletes B lymphocytes in vivo, primarily via indirect cytotoxic mechanisms. Direct effects on B cells may also contribute to B-cell depletion but are less clearly defined. In this report, we demonstrate that monomeric rit...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of immunotherapy 2010, Vol.33 (1), p.30-39
Hauptverfasser:	UNRUH, Tammy L, ZUCCOLO, Jonathan, BEERS, Stephen A, KANEVETS, Uliana, YAN SHI, DEANS, Julie P
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Immunotherapy Medical sciences Pharmacology. Drug treatments
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!