Congenital Scoliosis: Etiology and Associations
Literature review. To provide a current overview of congenital scoliosis and associated conditions. The etiology of congenital scoliosis is unknown. A variety of factors have been implicated in the development of vertebral abnormalities. These factors provide clues to the origin of congenital scolio...
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| Veröffentlicht in: | Spine (Philadelphia, Pa. 1976) Pa. 1976), 2009-08, Vol.34 (17), p.1745-1750 |
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| container_title | Spine (Philadelphia, Pa. 1976) |
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| creator | HENSINGER, Robert N |
| description | Literature review.
To provide a current overview of congenital scoliosis and associated conditions.
The etiology of congenital scoliosis is unknown. A variety of factors have been implicated in the development of vertebral abnormalities. These factors provide clues to the origin of congenital scoliosis.
A search of PubMed, using the keywords congenital scoliosis, etiology, and genetics was performed.
Environmental factors, genetics, vitamin deficiency, chemicals, and drugs, singly or in combination, have all been implicated in the development of vertebral abnormalities. Whatever the cause, the physiologic injury occurs early in the embryologic period, well before the development of cartilage and bone. The resulting defects can lead to full or partial fusion or lack of development of the vertebrae, which, in turn, can cause a curvature that, may be progressive during the growth of the child.
The origin of congenital scoliosis may be environmental, genetic, or a combination of factors. Research on these various factors continues. Early identification and management of concomitant defects can improve the patient's quality of life. |
| doi_str_mv | 10.1097/BRS.0b013e3181abf69e |
| format | Article |
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To provide a current overview of congenital scoliosis and associated conditions.
The etiology of congenital scoliosis is unknown. A variety of factors have been implicated in the development of vertebral abnormalities. These factors provide clues to the origin of congenital scoliosis.
A search of PubMed, using the keywords congenital scoliosis, etiology, and genetics was performed.
Environmental factors, genetics, vitamin deficiency, chemicals, and drugs, singly or in combination, have all been implicated in the development of vertebral abnormalities. Whatever the cause, the physiologic injury occurs early in the embryologic period, well before the development of cartilage and bone. The resulting defects can lead to full or partial fusion or lack of development of the vertebrae, which, in turn, can cause a curvature that, may be progressive during the growth of the child.
The origin of congenital scoliosis may be environmental, genetic, or a combination of factors. Research on these various factors continues. Early identification and management of concomitant defects can improve the patient's quality of life.</description><identifier>ISSN: 0362-2436</identifier><identifier>EISSN: 1528-1159</identifier><identifier>DOI: 10.1097/BRS.0b013e3181abf69e</identifier><identifier>PMID: 19602997</identifier><identifier>CODEN: SPINDD</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Animals ; Biological and medical sciences ; Body Patterning - genetics ; Causality ; Cerebrospinal fluid. Meninges. Spinal cord ; Child ; Diseases of striated muscles. Neuromuscular diseases ; Environmental Exposure - adverse effects ; Female ; Gene Expression Regulation, Developmental - genetics ; Genetic Predisposition to Disease - genetics ; Humans ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neurology ; Pregnancy ; Prenatal Exposure Delayed Effects - pathology ; Prenatal Exposure Delayed Effects - physiopathology ; Scoliosis - etiology ; Scoliosis - pathology ; Scoliosis - physiopathology ; Spine - abnormalities ; Spine - pathology ; Spine - physiopathology</subject><ispartof>Spine (Philadelphia, Pa. 1976), 2009-08, Vol.34 (17), p.1745-1750</ispartof><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c282t-1b12ef3776f3fa05a0b76ed0bc3fe3c281db0f2453f63da3aef1d93d6d4518e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21797975$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19602997$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HENSINGER, Robert N</creatorcontrib><title>Congenital Scoliosis: Etiology and Associations</title><title>Spine (Philadelphia, Pa. 1976)</title><addtitle>Spine (Phila Pa 1976)</addtitle><description>Literature review.
To provide a current overview of congenital scoliosis and associated conditions.
The etiology of congenital scoliosis is unknown. A variety of factors have been implicated in the development of vertebral abnormalities. These factors provide clues to the origin of congenital scoliosis.
A search of PubMed, using the keywords congenital scoliosis, etiology, and genetics was performed.
Environmental factors, genetics, vitamin deficiency, chemicals, and drugs, singly or in combination, have all been implicated in the development of vertebral abnormalities. Whatever the cause, the physiologic injury occurs early in the embryologic period, well before the development of cartilage and bone. The resulting defects can lead to full or partial fusion or lack of development of the vertebrae, which, in turn, can cause a curvature that, may be progressive during the growth of the child.
The origin of congenital scoliosis may be environmental, genetic, or a combination of factors. Research on these various factors continues. Early identification and management of concomitant defects can improve the patient's quality of life.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Patterning - genetics</subject><subject>Causality</subject><subject>Cerebrospinal fluid. Meninges. Spinal cord</subject><subject>Child</subject><subject>Diseases of striated muscles. Neuromuscular diseases</subject><subject>Environmental Exposure - adverse effects</subject><subject>Female</subject><subject>Gene Expression Regulation, Developmental - genetics</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects - pathology</subject><subject>Prenatal Exposure Delayed Effects - physiopathology</subject><subject>Scoliosis - etiology</subject><subject>Scoliosis - pathology</subject><subject>Scoliosis - physiopathology</subject><subject>Spine - abnormalities</subject><subject>Spine - pathology</subject><subject>Spine - physiopathology</subject><issn>0362-2436</issn><issn>1528-1159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdj01Lw0AQQBdRbK3-A5FcPMbO7CSbrLda6gcUBKvnsJ9lJc2WbD303xtpUZA5DAzvDTzGrhHuEGQ1fXhb3YEGJEdYo9JeSHfCxljyOkcs5SkbAwme84LEiF2k9AkAglCesxFKAVzKasym89itXRd2qs1WJrYhppDus8UuxDau95nqbDZLKZqghlOXLtmZV21yV8c9YR-Pi_f5c758fXqZz5a54TXf5aiRO09VJTx5BaUCXQlnQRvyjgYGrQbPi5K8IKtIOY9WkhW2KLF2NU1Ycfhr-phS73yz7cNG9fsGofnpb4b-5n__oN0ctO2X3jj7Jx2DB-D2CKhkVOt71ZmQfjmOlRympG8M3mUd</recordid><startdate>20090801</startdate><enddate>20090801</enddate><creator>HENSINGER, Robert N</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20090801</creationdate><title>Congenital Scoliosis: Etiology and Associations</title><author>HENSINGER, Robert N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c282t-1b12ef3776f3fa05a0b76ed0bc3fe3c281db0f2453f63da3aef1d93d6d4518e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Patterning - genetics</topic><topic>Causality</topic><topic>Cerebrospinal fluid. Meninges. Spinal cord</topic><topic>Child</topic><topic>Diseases of striated muscles. Neuromuscular diseases</topic><topic>Environmental Exposure - adverse effects</topic><topic>Female</topic><topic>Gene Expression Regulation, Developmental - genetics</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects - pathology</topic><topic>Prenatal Exposure Delayed Effects - physiopathology</topic><topic>Scoliosis - etiology</topic><topic>Scoliosis - pathology</topic><topic>Scoliosis - physiopathology</topic><topic>Spine - abnormalities</topic><topic>Spine - pathology</topic><topic>Spine - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HENSINGER, Robert N</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Spine (Philadelphia, Pa. 1976)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HENSINGER, Robert N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Congenital Scoliosis: Etiology and Associations</atitle><jtitle>Spine (Philadelphia, Pa. 1976)</jtitle><addtitle>Spine (Phila Pa 1976)</addtitle><date>2009-08-01</date><risdate>2009</risdate><volume>34</volume><issue>17</issue><spage>1745</spage><epage>1750</epage><pages>1745-1750</pages><issn>0362-2436</issn><eissn>1528-1159</eissn><coden>SPINDD</coden><abstract>Literature review.
To provide a current overview of congenital scoliosis and associated conditions.
The etiology of congenital scoliosis is unknown. A variety of factors have been implicated in the development of vertebral abnormalities. These factors provide clues to the origin of congenital scoliosis.
A search of PubMed, using the keywords congenital scoliosis, etiology, and genetics was performed.
Environmental factors, genetics, vitamin deficiency, chemicals, and drugs, singly or in combination, have all been implicated in the development of vertebral abnormalities. Whatever the cause, the physiologic injury occurs early in the embryologic period, well before the development of cartilage and bone. The resulting defects can lead to full or partial fusion or lack of development of the vertebrae, which, in turn, can cause a curvature that, may be progressive during the growth of the child.
The origin of congenital scoliosis may be environmental, genetic, or a combination of factors. Research on these various factors continues. Early identification and management of concomitant defects can improve the patient's quality of life.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>19602997</pmid><doi>10.1097/BRS.0b013e3181abf69e</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0362-2436 |
| ispartof | Spine (Philadelphia, Pa. 1976), 2009-08, Vol.34 (17), p.1745-1750 |
| issn | 0362-2436 1528-1159 |
| language | eng |
| recordid | cdi_crossref_primary_10_1097_BRS_0b013e3181abf69e |
| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Animals Biological and medical sciences Body Patterning - genetics Causality Cerebrospinal fluid. Meninges. Spinal cord Child Diseases of striated muscles. Neuromuscular diseases Environmental Exposure - adverse effects Female Gene Expression Regulation, Developmental - genetics Genetic Predisposition to Disease - genetics Humans Medical sciences Nervous system (semeiology, syndromes) Neurology Pregnancy Prenatal Exposure Delayed Effects - pathology Prenatal Exposure Delayed Effects - physiopathology Scoliosis - etiology Scoliosis - pathology Scoliosis - physiopathology Spine - abnormalities Spine - pathology Spine - physiopathology |
| title | Congenital Scoliosis: Etiology and Associations |
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