The Effect of Substance P on an Intervertebral Disc Rat Organ Culture Model

STUDY DESIGN.Laboratory study. OBJECTIVE.Evaluate the effect of substance P (SP) on an intervertebral disc rat organ culture model. SUMMARY OF BACKGROUND DATA.Monolayer cell experiments have demonstrated that exposure intervertebral disc tissue cells to SP leads to upregulation in inflammatory cytok...

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Veröffentlicht in:	Spine (Philadelphia, Pa. 1976) Pa. 1976), 2016-12, Vol.41 (24), p.1851-1859
Hauptverfasser:	Koerner, John D., Markova, Dessislava Z., Schroeder, Gregory D., Rihn, Jeffery A., Hilibrand, Alan S., Vaccaro, Alexander R., Anderson, D. Greg, Kepler, Christopher K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured - drug effects Cytokines - metabolism Interleukin-1beta - metabolism Intervertebral Disc - drug effects Intervertebral Disc - metabolism Intervertebral Disc Degeneration - drug therapy Intervertebral Disc Degeneration - metabolism Organ Culture Techniques Rats Real-Time Polymerase Chain Reaction - methods Substance P - pharmacology Up-Regulation - drug effects
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