Ecthyma Gangrenosum Following Toxic Epidermal Necrolysis Syndrome in a 3-Year-Old Boy : a Survivable Series of Events
Toxic epidermal necrolysis syndrome (TENS) is a severe but rare skin reaction leading to epidermal desquamation of greater than 30% of the TBSA. It is most commonly precipitated by the administration of medication. Frequent complications of this syndrome include local wound infections, respiratory,...
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| Veröffentlicht in: | Journal of burn care & research 2008-05, Vol.29 (3), p.555-558 |
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| container_title | Journal of burn care & research |
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| creator | GRESIK, Christine M BREWSTER, Luke P ABOOD, Gerard SUPPLE, Kathy G SILVER, Geoffrey M GAMELLI, Richard L NICKOLOFF, Brian J |
| description | Toxic epidermal necrolysis syndrome (TENS) is a severe but rare skin reaction leading to epidermal desquamation of greater than 30% of the TBSA. It is most commonly precipitated by the administration of medication. Frequent complications of this syndrome include local wound infections, respiratory, mucocutaneous, and ocular complications. Ecthyma gangrenosum (EG) is a rare disease characterized by a milliary seeding of the cutaneous tissue with Gram-negative bacteria; it is most commonly seen in immunocompromised individuals. Here we report a 3-year-old boy who developed EG subsequent to TENS. Although he had a complicated and prolonged hospital course, he survived these series of events. To our knowledge, this is the first reported case of TENS/EG in the pediatric population, and the first report of survivability following these illnesses. |
| doi_str_mv | 10.1097/BCR.0b013e318171136a |
| format | Article |
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It is most commonly precipitated by the administration of medication. Frequent complications of this syndrome include local wound infections, respiratory, mucocutaneous, and ocular complications. Ecthyma gangrenosum (EG) is a rare disease characterized by a milliary seeding of the cutaneous tissue with Gram-negative bacteria; it is most commonly seen in immunocompromised individuals. Here we report a 3-year-old boy who developed EG subsequent to TENS. Although he had a complicated and prolonged hospital course, he survived these series of events. To our knowledge, this is the first reported case of TENS/EG in the pediatric population, and the first report of survivability following these illnesses.</description><identifier>ISSN: 1559-047X</identifier><identifier>EISSN: 1559-0488</identifier><identifier>DOI: 10.1097/BCR.0b013e318171136a</identifier><identifier>PMID: 18388562</identifier><language>eng</language><publisher>Philadelphia, PA: Lippincott Williams & Wilkins</publisher><subject>Anti-Bacterial Agents - therapeutic use ; Bacterial diseases ; Bacterial diseases of the skin ; Biological and medical sciences ; Bullous diseases of the skin ; Burns ; Child, Preschool ; Dermatology ; Ecthyma - drug therapy ; Ecthyma - etiology ; Ecthyma - microbiology ; Gangrene - drug therapy ; Gangrene - etiology ; Gangrene - microbiology ; Gram-Negative Bacterial Infections - drug therapy ; Gram-Negative Bacterial Infections - microbiology ; Human bacterial diseases ; Humans ; Imipenem - therapeutic use ; Infectious diseases ; Male ; Medical sciences ; Risk Factors ; Skin Transplantation ; Stevens-Johnson Syndrome - complications ; Stevens-Johnson Syndrome - microbiology ; Stevens-Johnson Syndrome - surgery ; Tobramycin - therapeutic use ; Traumas. 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It is most commonly precipitated by the administration of medication. Frequent complications of this syndrome include local wound infections, respiratory, mucocutaneous, and ocular complications. Ecthyma gangrenosum (EG) is a rare disease characterized by a milliary seeding of the cutaneous tissue with Gram-negative bacteria; it is most commonly seen in immunocompromised individuals. Here we report a 3-year-old boy who developed EG subsequent to TENS. Although he had a complicated and prolonged hospital course, he survived these series of events. To our knowledge, this is the first reported case of TENS/EG in the pediatric population, and the first report of survivability following these illnesses.</description><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the skin</subject><subject>Biological and medical sciences</subject><subject>Bullous diseases of the skin</subject><subject>Burns</subject><subject>Child, Preschool</subject><subject>Dermatology</subject><subject>Ecthyma - drug therapy</subject><subject>Ecthyma - etiology</subject><subject>Ecthyma - microbiology</subject><subject>Gangrene - drug therapy</subject><subject>Gangrene - etiology</subject><subject>Gangrene - microbiology</subject><subject>Gram-Negative Bacterial Infections - drug therapy</subject><subject>Gram-Negative Bacterial Infections - microbiology</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Imipenem - therapeutic use</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Risk Factors</subject><subject>Skin Transplantation</subject><subject>Stevens-Johnson Syndrome - complications</subject><subject>Stevens-Johnson Syndrome - microbiology</subject><subject>Stevens-Johnson Syndrome - surgery</subject><subject>Tobramycin - therapeutic use</subject><subject>Traumas. Diseases due to physical agents</subject><issn>1559-047X</issn><issn>1559-0488</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkFtLw0AQhRdRbK3-A5F98TF1r83GN1vSKhQLtoI-hclmU1dyKbtNNf_eSEsFn2aYOWc48yF0TcmQkii8G09ehiQllBtOFQ0p5SM4QX0qZRQQodTpsQ_feujC-09ChCChPEc9qrhScsT6qIn19qMtAc-gWjtT1b4p8bQuivrLVmu8qr-txvHGZsaVUOBno11dtN56vGyrzNWlwbbCgHnwbsAFiyLD47rF991o2bid3UFaGLw0zhqP6xzHO1Nt_SU6y6Hw5upQB-h1Gq8mj8F8MXuaPMwDzbncBkxIzcRIAMtlpqTOBSjQaUiNZHmqum0UUsF1pHmaApMZMAoyyhTtHsyk4AMk9ne71N47kycbZ0twbUJJ8ksx6Sgm_yl2tpu9bdOkpcn-TAdsneD2IACvocgdVNr6o44RLgTjgv8AfIR7sw</recordid><startdate>20080501</startdate><enddate>20080501</enddate><creator>GRESIK, Christine M</creator><creator>BREWSTER, Luke P</creator><creator>ABOOD, Gerard</creator><creator>SUPPLE, Kathy G</creator><creator>SILVER, Geoffrey M</creator><creator>GAMELLI, Richard L</creator><creator>NICKOLOFF, Brian J</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20080501</creationdate><title>Ecthyma Gangrenosum Following Toxic Epidermal Necrolysis Syndrome in a 3-Year-Old Boy : a Survivable Series of Events</title><author>GRESIK, Christine M ; BREWSTER, Luke P ; ABOOD, Gerard ; SUPPLE, Kathy G ; SILVER, Geoffrey M ; GAMELLI, Richard L ; NICKOLOFF, Brian J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-245c2464a2f5d85cf4a8acb71e52fb845c97143c9c3bba25da21a59d81183d543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the skin</topic><topic>Biological and medical sciences</topic><topic>Bullous diseases of the skin</topic><topic>Burns</topic><topic>Child, Preschool</topic><topic>Dermatology</topic><topic>Ecthyma - drug therapy</topic><topic>Ecthyma - etiology</topic><topic>Ecthyma - microbiology</topic><topic>Gangrene - drug therapy</topic><topic>Gangrene - etiology</topic><topic>Gangrene - microbiology</topic><topic>Gram-Negative Bacterial Infections - drug therapy</topic><topic>Gram-Negative Bacterial Infections - microbiology</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Imipenem - therapeutic use</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Risk Factors</topic><topic>Skin Transplantation</topic><topic>Stevens-Johnson Syndrome - complications</topic><topic>Stevens-Johnson Syndrome - microbiology</topic><topic>Stevens-Johnson Syndrome - surgery</topic><topic>Tobramycin - therapeutic use</topic><topic>Traumas. Diseases due to physical agents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GRESIK, Christine M</creatorcontrib><creatorcontrib>BREWSTER, Luke P</creatorcontrib><creatorcontrib>ABOOD, Gerard</creatorcontrib><creatorcontrib>SUPPLE, Kathy G</creatorcontrib><creatorcontrib>SILVER, Geoffrey M</creatorcontrib><creatorcontrib>GAMELLI, Richard L</creatorcontrib><creatorcontrib>NICKOLOFF, Brian J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of burn care & research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GRESIK, Christine M</au><au>BREWSTER, Luke P</au><au>ABOOD, Gerard</au><au>SUPPLE, Kathy G</au><au>SILVER, Geoffrey M</au><au>GAMELLI, Richard L</au><au>NICKOLOFF, Brian J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ecthyma Gangrenosum Following Toxic Epidermal Necrolysis Syndrome in a 3-Year-Old Boy : a Survivable Series of Events</atitle><jtitle>Journal of burn care & research</jtitle><addtitle>J Burn Care Res</addtitle><date>2008-05-01</date><risdate>2008</risdate><volume>29</volume><issue>3</issue><spage>555</spage><epage>558</epage><pages>555-558</pages><issn>1559-047X</issn><eissn>1559-0488</eissn><abstract>Toxic epidermal necrolysis syndrome (TENS) is a severe but rare skin reaction leading to epidermal desquamation of greater than 30% of the TBSA. It is most commonly precipitated by the administration of medication. Frequent complications of this syndrome include local wound infections, respiratory, mucocutaneous, and ocular complications. Ecthyma gangrenosum (EG) is a rare disease characterized by a milliary seeding of the cutaneous tissue with Gram-negative bacteria; it is most commonly seen in immunocompromised individuals. Here we report a 3-year-old boy who developed EG subsequent to TENS. Although he had a complicated and prolonged hospital course, he survived these series of events. To our knowledge, this is the first reported case of TENS/EG in the pediatric population, and the first report of survivability following these illnesses.</abstract><cop>Philadelphia, PA</cop><pub>Lippincott Williams & Wilkins</pub><pmid>18388562</pmid><doi>10.1097/BCR.0b013e318171136a</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Journals@Ovid Complete; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Anti-Bacterial Agents - therapeutic use Bacterial diseases Bacterial diseases of the skin Biological and medical sciences Bullous diseases of the skin Burns Child, Preschool Dermatology Ecthyma - drug therapy Ecthyma - etiology Ecthyma - microbiology Gangrene - drug therapy Gangrene - etiology Gangrene - microbiology Gram-Negative Bacterial Infections - drug therapy Gram-Negative Bacterial Infections - microbiology Human bacterial diseases Humans Imipenem - therapeutic use Infectious diseases Male Medical sciences Risk Factors Skin Transplantation Stevens-Johnson Syndrome - complications Stevens-Johnson Syndrome - microbiology Stevens-Johnson Syndrome - surgery Tobramycin - therapeutic use Traumas. Diseases due to physical agents |
| title | Ecthyma Gangrenosum Following Toxic Epidermal Necrolysis Syndrome in a 3-Year-Old Boy : a Survivable Series of Events |
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