Rifampin Greatly Reduces the Plasma Concentrations of Intravenous and Oral Oxycodone

Oxycodone is a mu-opioid receptor agonist that is metabolized mainly in the liver by cytochrome P450 3A and 2D6 enzymes. Rifampin is a strong inducer of several drug-metabolizing enzymes. The authors studied the interaction of rifampin with oxycodone. Their hypothesis was that rifampin enhances the...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 2009-06, Vol.110 (6), p.1371-1378
Hauptverfasser:	NIEMINEN, Tuija H, HAGELBERG, Nora M, SAARI, Teijo I, PERTOVAARA, Antti, NEUVONEN, Mikko, LAINE, Kari, NEUVONEN, Pertti J, OLKKOLA, Klaus T
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Analgesics, Opioid - administration & dosage Analgesics, Opioid - blood Analgesics, Opioid - pharmacokinetics Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anti-Bacterial Agents - adverse effects Biological and medical sciences Biological Availability Cross-Over Studies Cytochrome P-450 CYP3A - biosynthesis Cytochrome P-450 CYP3A - metabolism Double-Blind Method Drug Interactions Enzyme Induction - drug effects Female Half-Life Humans Injections, Intravenous Male Medical sciences Oxycodone - administration & dosage Oxycodone - blood Oxycodone - pharmacokinetics Rifampin - adverse effects Young Adult
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