Anesthesia with Disuse Leads to Autophagy Up-regulation in the Skeletal Muscle

It has been known that skeletal muscles show atrophic changes after prolonged sedation or general anesthesia. Whether these effects are due to anesthesia itself or disuse during anesthesia has not been fully clarified. Autophagy dysregulation has been implicated in muscle-wasting conditions. This st...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 2015-05, Vol.122 (5), p.1075-1083
Hauptverfasser:	Kashiwagi, Aki, Hosokawa, Sachiko, Maeyama, Yoshihiro, Ueki, Ryusuke, Kaneki, Masao, Martyn, J A Jeevendra, Yasuhara, Shingo
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Animals Autophagy - drug effects Denervation Electric Stimulation Hypnotics and Sedatives Mice Mice, Inbred C57BL Mice, Transgenic Microtubule-Associated Proteins - genetics Muscle Contraction - drug effects Muscle, Skeletal - drug effects Muscle, Skeletal - pathology Muscular Disorders, Atrophic - pathology Pentobarbital Up-Regulation - drug effects
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