Down-regulation of MicroRNA-21 Is Involved in the Propofol-induced Neurotoxicity Observed in Human Stem Cell–derived Neurons

BACKGROUND:Recent studies in various animal models have suggested that anesthetics such as propofol, when administered early in life, can lead to neurotoxicity. These studies have raised significant safety concerns regarding the use of anesthetics in the pediatric population and highlight the need f...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 2014-10, Vol.121 (4), p.786-800
Hauptverfasser:	Twaroski, Danielle M, Yan, Yasheng, Olson, Jessica M, Bosnjak, Zeljko J, Bai, Xiaowen
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics, Intravenous - toxicity Animals Cell Differentiation - drug effects Cell Differentiation - physiology Coculture Techniques Dose-Response Relationship, Drug Down-Regulation - drug effects Down-Regulation - physiology Humans Mice MicroRNAs - metabolism Neural Stem Cells - drug effects Neural Stem Cells - metabolism Neurons - drug effects Neurons - metabolism Propofol - toxicity
Online-Zugang:	Volltext
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