Local anesthetic 'in-situ' toxicity during peripheral nerve blocks: update on mechanisms and prevention

Peripheral nerve blocks induce undesired side-effects linked to the toxicity of local anesthetics on neuron and myocytes via different cell targets. The effects of local anesthetics on these targets are now well known and summarized in this review. Local anesthetic-induced local cell toxicity involv...

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Veröffentlicht in:	Current opinion in anaesthesiology 2012-10, Vol.25 (5), p.589-595
Hauptverfasser:	Nouette-Gaulain, Karine, Capdevila, Xavier, Rossignol, Rodrigue
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics, Local - adverse effects Anesthetics, Local - toxicity Energy Metabolism - drug effects Humans Intraoperative Complications - prevention & control Mitochondria, Muscle - drug effects Mitochondria, Muscle - pathology Muscle Fibers, Skeletal - drug effects Muscle Fibers, Skeletal - pathology Muscle Fibers, Skeletal - ultrastructure Nerve Block - adverse effects Neurons - drug effects Neurons - pathology Neurons - ultrastructure Peripheral Nerves
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