Component-resolved diagnosis in pediatric allergic rhinoconjunctivitis and asthma
PURPOSE OF REVIEWThe aim of this review is to update readers on the growing impact of a molecular approach (CRD) to the diagnosis and treatment of children with respiratory allergies RECENT FINDINGSA large panel of highly purified natural or recombinant species-specific and cross-reacting allergenic...
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| Veröffentlicht in: | Current opinion in allergy and clinical immunology 2013-08, Vol.13 (4), p.446-451 |
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| container_title | Current opinion in allergy and clinical immunology |
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| creator | Melioli, Giovanni Passalacqua, Giovanni Canonica, Giorgio Walter Baena-Cagnani, Carlos E Matricardi, Paolo |
| description | PURPOSE OF REVIEWThe aim of this review is to update readers on the growing impact of a molecular approach (CRD) to the diagnosis and treatment of children with respiratory allergies
RECENT FINDINGSA large panel of highly purified natural or recombinant species-specific and cross-reacting allergenic molecules is now available for clinical purposes. Species-specific molecules allow identifying specific sensitization toward a given allergenic source. Cross-reacting molecules allow interpreting polysensitization patterns that cannot be detailed using routine skin prick tests or specific IgE tests based on allergenic extracts. These molecular tools are transforming and improving the interpretation of clinical and laboratory tests used to define patients’ IgE-sensitization profile.
SUMMARYThe accurate dissection of the IgE repertoire offers new possibilities in the diagnosis, prophylaxis and treatment of pediatric allergic rhinoconjunctivitis and asthma. |
| doi_str_mv | 10.1097/ACI.0b013e32836274d8 |
| format | Article |
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RECENT FINDINGSA large panel of highly purified natural or recombinant species-specific and cross-reacting allergenic molecules is now available for clinical purposes. Species-specific molecules allow identifying specific sensitization toward a given allergenic source. Cross-reacting molecules allow interpreting polysensitization patterns that cannot be detailed using routine skin prick tests or specific IgE tests based on allergenic extracts. These molecular tools are transforming and improving the interpretation of clinical and laboratory tests used to define patients’ IgE-sensitization profile.
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RECENT FINDINGSA large panel of highly purified natural or recombinant species-specific and cross-reacting allergenic molecules is now available for clinical purposes. Species-specific molecules allow identifying specific sensitization toward a given allergenic source. Cross-reacting molecules allow interpreting polysensitization patterns that cannot be detailed using routine skin prick tests or specific IgE tests based on allergenic extracts. These molecular tools are transforming and improving the interpretation of clinical and laboratory tests used to define patients’ IgE-sensitization profile.
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| ispartof | Current opinion in allergy and clinical immunology, 2013-08, Vol.13 (4), p.446-451 |
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| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Adolescent Allergens - immunology Asthma - diagnosis Asthma - immunology Asthma - therapy Child Child, Preschool Conjunctivitis, Allergic - diagnosis Conjunctivitis, Allergic - immunology Conjunctivitis, Allergic - therapy Cross Reactions Diagnosis, Differential Female Humans Immunoglobulin E - metabolism Infant Infant, Newborn Male Rhinitis, Allergic, Perennial - diagnosis Rhinitis, Allergic, Perennial - immunology Rhinitis, Allergic, Perennial - therapy Skin Tests - methods |
| title | Component-resolved diagnosis in pediatric allergic rhinoconjunctivitis and asthma |
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