Sap is necessary for mediating antigen-specific effector functions of CD4+ AND CD8+ T cells

X-linked lymphoproliferative disease (XLP) is a rare immunodeficiency caused by mutations in SH2D1A which encodes SAP (SLAM-associated protein). SAP functions as an adaptor protein downstream of the SLAM family of cell surface receptors, thereby contributing to lymphocyte activation. The major defec...

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Veröffentlicht in:	Pathology 2010, Vol.42, p.S45-S45
Hauptverfasser:	Tangye, Stuart G., Palendira, Umaimainthan, Low, Carol, Deenick, Elissa K., Chan, Anna, Ma, Cindy S., Brink, Robert, Alvaro, Frank, Cook, Matthew C., Sean Riminton, D., Nichols, Kim E., Schwartzberg, Pamela L.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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