An Increase in Prostacyclin Accompanies Reduction in Blood Pressure Following Peritoneal Closure in Patients Undergoing Cesarean Section

An Increase in Prostacyclin Accompanies Reduction in Blood Pressure Following Peritoneal Closure in Patients Undergoing Cesarean Section

A prospective study in 50 parturients confirmed the clinical impression that peritoneal closure at cesarean section is frequently accompanied by falls in BP and rises in HR. Maximal changes were observed 5 ± 1 min after the start of closure, and recovery occurred within 20 min. Based on a report by...

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Veröffentlicht in:Obstetric anesthesia digest 1990-01, Vol.9 (4), p.246-246
Hauptverfasser: Matsumoto, M, Oka, H, Oshibuchi, T
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container_title Obstetric anesthesia digest
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creator Matsumoto, M
Oka, H
Oshibuchi, T
description A prospective study in 50 parturients confirmed the clinical impression that peritoneal closure at cesarean section is frequently accompanied by falls in BP and rises in HR. Maximal changes were observed 5 ± 1 min after the start of closure, and recovery occurred within 20 min. Based on a report by Seltzer et al. (Anesthesiology 68, 1988), an association with prostacyclin (PGI2) was investigated. Arterial blood samples were obtained in 4 women undergoing elective cesarean section, before the epidural injection of 2% mepivacaine and at two different stages during peritoneal closure, for determination of plasma 6-keto-PGFioc, which is the stable breakdown product of PGI2. Striking increases in PGF1 concentration accompanied the reduction in BP; simultaneously, there developed erythema and/or flushing of face and palms.
doi_str_mv 10.1097/00132582-199001000-00072
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title An Increase in Prostacyclin Accompanies Reduction in Blood Pressure Following Peritoneal Closure in Patients Undergoing Cesarean Section
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