Mosquito bite pathogenesis in necrotic skin reactors
Mosquito bite exposure results in a variety of reactions and secondary complications. Clinical hypersensitivity manifests primarily as local reactions with anaphylaxis being a very rare event. Risk factors for more severe local reactions include immunodeficiency, young children and visitors to an ar...
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| Veröffentlicht in: | Current opinion in allergy and clinical immunology 2001-08, Vol.1 (4), p.349-352 |
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| container_title | Current opinion in allergy and clinical immunology |
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| creator | Engler, Renata J.M |
| description | Mosquito bite exposure results in a variety of reactions and secondary complications. Clinical hypersensitivity manifests primarily as local reactions with anaphylaxis being a very rare event. Risk factors for more severe local reactions include immunodeficiency, young children and visitors to an area with new exposure to indigenous mosquitoes. Necrotic skin reactions to mosquito bites have been associated with a newly recognized hemophagocytic syndrome in predominantly oriental populations. Diagnostic and therapeutic agents in the clinical management of mosquito hypersensitivity remain limited, but recent discovery of 3 recombinant proteins (rAed a 1, rAed a 2, rAed a 3) shared by several mosquito species promise to be more specific skin test antigens for the future. |
| doi_str_mv | 10.1097/00130832-200108000-00011 |
| format | Article |
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Clinical hypersensitivity manifests primarily as local reactions with anaphylaxis being a very rare event. Risk factors for more severe local reactions include immunodeficiency, young children and visitors to an area with new exposure to indigenous mosquitoes. Necrotic skin reactions to mosquito bites have been associated with a newly recognized hemophagocytic syndrome in predominantly oriental populations. 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| fulltext | fulltext |
| identifier | ISSN: 1528-4050 |
| ispartof | Current opinion in allergy and clinical immunology, 2001-08, Vol.1 (4), p.349-352 |
| issn | 1528-4050 1473-6322 |
| language | eng |
| recordid | cdi_crossref_primary_10_1097_00130832_200108000_00011 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Allergens - immunology Animals Culicidae Humans Hypersensitivity - etiology Hypersensitivity - physiopathology Hypersensitivity - therapy Insect Bites and Stings - immunology Necrosis Skin - immunology Skin - pathology |
| title | Mosquito bite pathogenesis in necrotic skin reactors |
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