Latanoprost-induced Iris Color Darkening: A Case Report With Long-term Follow-up
PURPOSE:To determine the effect on iris color of discontinuing latanoprost (LP) treatment in a patient with pronounced iris color darkening, and to assess the possible role of sympathetic innervation. METHODS:In a patient demonstrating pronounced iris color darkening in both eyes after treatment wit...
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| Veröffentlicht in: | Journal of glaucoma 2000-02, Vol.9 (1), p.95-98 |
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| container_title | Journal of glaucoma |
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| creator | Camras, Carl B Neely, Donna G Weiss, Ellen L |
| description | PURPOSE:To determine the effect on iris color of discontinuing latanoprost (LP) treatment in a patient with pronounced iris color darkening, and to assess the possible role of sympathetic innervation.
METHODS:In a patient demonstrating pronounced iris color darkening in both eyes after treatment with LP for 6 months, magnified iris color photographs were taken at 3- to 6-month intervals for 5 years after discontinuation of LP treatment. Pupillary testing for sympathetic insufficiency was performed with cocaine 10% or hydroxyamphetamine 1%.
RESULTS:The iris color did not appreciably change after discontinuing LP. The cocaine-induced increase in pupillary diameter was considerably greater for the control subject than for the patient who demonstrated the LP-induced color change.
CONCLUSIONS:Latanoprost-induced iris color darkening does not appreciably change for several years after discontinuing treatment. Some eyes that show LPinduced darkening may have relative ocular sympathetic insufficiency. |
| doi_str_mv | 10.1097/00061198-200002000-00016 |
| format | Article |
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METHODS:In a patient demonstrating pronounced iris color darkening in both eyes after treatment with LP for 6 months, magnified iris color photographs were taken at 3- to 6-month intervals for 5 years after discontinuation of LP treatment. Pupillary testing for sympathetic insufficiency was performed with cocaine 10% or hydroxyamphetamine 1%.
RESULTS:The iris color did not appreciably change after discontinuing LP. The cocaine-induced increase in pupillary diameter was considerably greater for the control subject than for the patient who demonstrated the LP-induced color change.
CONCLUSIONS:Latanoprost-induced iris color darkening does not appreciably change for several years after discontinuing treatment. Some eyes that show LPinduced darkening may have relative ocular sympathetic insufficiency.</description><identifier>ISSN: 1057-0829</identifier><identifier>EISSN: 1536-481X</identifier><identifier>DOI: 10.1097/00061198-200002000-00016</identifier><identifier>PMID: 10708238</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins, Inc</publisher><subject>Antihypertensive Agents - adverse effects ; Autonomic Nervous System Diseases - diagnosis ; Cocaine - administration & dosage ; Follow-Up Studies ; Glaucoma, Open-Angle - drug therapy ; Humans ; Intraocular Pressure - drug effects ; Iris - drug effects ; Iris - innervation ; Iris Diseases - chemically induced ; Iris Diseases - pathology ; Male ; Middle Aged ; Ophthalmic Solutions ; Pigmentation Disorders - chemically induced ; Pigmentation Disorders - pathology ; Prostaglandins F, Synthetic - adverse effects ; Pupil - drug effects ; Sympathetic Nervous System - pathology</subject><ispartof>Journal of glaucoma, 2000-02, Vol.9 (1), p.95-98</ispartof><rights>2000 Lippincott Williams & Wilkins, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3566-98af02721c22e32efff8af169b1b2b8602c75d7e51c1881b50e073e1245c761b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10708238$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Camras, Carl B</creatorcontrib><creatorcontrib>Neely, Donna G</creatorcontrib><creatorcontrib>Weiss, Ellen L</creatorcontrib><title>Latanoprost-induced Iris Color Darkening: A Case Report With Long-term Follow-up</title><title>Journal of glaucoma</title><addtitle>J Glaucoma</addtitle><description>PURPOSE:To determine the effect on iris color of discontinuing latanoprost (LP) treatment in a patient with pronounced iris color darkening, and to assess the possible role of sympathetic innervation.
METHODS:In a patient demonstrating pronounced iris color darkening in both eyes after treatment with LP for 6 months, magnified iris color photographs were taken at 3- to 6-month intervals for 5 years after discontinuation of LP treatment. Pupillary testing for sympathetic insufficiency was performed with cocaine 10% or hydroxyamphetamine 1%.
RESULTS:The iris color did not appreciably change after discontinuing LP. The cocaine-induced increase in pupillary diameter was considerably greater for the control subject than for the patient who demonstrated the LP-induced color change.
CONCLUSIONS:Latanoprost-induced iris color darkening does not appreciably change for several years after discontinuing treatment. Some eyes that show LPinduced darkening may have relative ocular sympathetic insufficiency.</description><subject>Antihypertensive Agents - adverse effects</subject><subject>Autonomic Nervous System Diseases - diagnosis</subject><subject>Cocaine - administration & dosage</subject><subject>Follow-Up Studies</subject><subject>Glaucoma, Open-Angle - drug therapy</subject><subject>Humans</subject><subject>Intraocular Pressure - drug effects</subject><subject>Iris - drug effects</subject><subject>Iris - innervation</subject><subject>Iris Diseases - chemically induced</subject><subject>Iris Diseases - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Ophthalmic Solutions</subject><subject>Pigmentation Disorders - chemically induced</subject><subject>Pigmentation Disorders - pathology</subject><subject>Prostaglandins F, Synthetic - adverse effects</subject><subject>Pupil - drug effects</subject><subject>Sympathetic Nervous System - pathology</subject><issn>1057-0829</issn><issn>1536-481X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kF1LwzAUhoMobn78BckfiOaka5J6N6rTQUERRe9C2qZbXdeUpGX4782sijdenA8O73s450EIA70EmogrSikHSCRhoaP7REIAP0BTiCNOZhLeDkNPY0GoZMkEnXj_vlcyBsdoAlSEcSSn6DHTvW5t56zvSd2WQ2FKvHS1x6ltrMM32m1MW7erazzHqfYGP5nOuh6_1v0aZ7Zdkd64LV7YprE7MnRn6KjSjTfn3_UUvSxun9N7kj3cLdN5Rooo5pwkUleUCQYFYyZipqqqMAGe5JCzXHLKChGXwsRQgJSQx9RQERlgs7gQHPLoFMlxbxFO985UqnP1VrsPBVTtIakfSOoXkvqCFKwXo7Ub8q0p_xhHKkEwGwU724Tv_KYZdsaptdFNv1b_wY8-AQZJcFc</recordid><startdate>200002</startdate><enddate>200002</enddate><creator>Camras, Carl B</creator><creator>Neely, Donna G</creator><creator>Weiss, Ellen L</creator><general>Lippincott Williams & Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200002</creationdate><title>Latanoprost-induced Iris Color Darkening: A Case Report With Long-term Follow-up</title><author>Camras, Carl B ; Neely, Donna G ; Weiss, Ellen L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3566-98af02721c22e32efff8af169b1b2b8602c75d7e51c1881b50e073e1245c761b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Antihypertensive Agents - adverse effects</topic><topic>Autonomic Nervous System Diseases - diagnosis</topic><topic>Cocaine - administration & dosage</topic><topic>Follow-Up Studies</topic><topic>Glaucoma, Open-Angle - drug therapy</topic><topic>Humans</topic><topic>Intraocular Pressure - drug effects</topic><topic>Iris - drug effects</topic><topic>Iris - innervation</topic><topic>Iris Diseases - chemically induced</topic><topic>Iris Diseases - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Ophthalmic Solutions</topic><topic>Pigmentation Disorders - chemically induced</topic><topic>Pigmentation Disorders - pathology</topic><topic>Prostaglandins F, Synthetic - adverse effects</topic><topic>Pupil - drug effects</topic><topic>Sympathetic Nervous System - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Camras, Carl B</creatorcontrib><creatorcontrib>Neely, Donna G</creatorcontrib><creatorcontrib>Weiss, Ellen L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of glaucoma</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Camras, Carl B</au><au>Neely, Donna G</au><au>Weiss, Ellen L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Latanoprost-induced Iris Color Darkening: A Case Report With Long-term Follow-up</atitle><jtitle>Journal of glaucoma</jtitle><addtitle>J Glaucoma</addtitle><date>2000-02</date><risdate>2000</risdate><volume>9</volume><issue>1</issue><spage>95</spage><epage>98</epage><pages>95-98</pages><issn>1057-0829</issn><eissn>1536-481X</eissn><abstract>PURPOSE:To determine the effect on iris color of discontinuing latanoprost (LP) treatment in a patient with pronounced iris color darkening, and to assess the possible role of sympathetic innervation.
METHODS:In a patient demonstrating pronounced iris color darkening in both eyes after treatment with LP for 6 months, magnified iris color photographs were taken at 3- to 6-month intervals for 5 years after discontinuation of LP treatment. Pupillary testing for sympathetic insufficiency was performed with cocaine 10% or hydroxyamphetamine 1%.
RESULTS:The iris color did not appreciably change after discontinuing LP. The cocaine-induced increase in pupillary diameter was considerably greater for the control subject than for the patient who demonstrated the LP-induced color change.
CONCLUSIONS:Latanoprost-induced iris color darkening does not appreciably change for several years after discontinuing treatment. Some eyes that show LPinduced darkening may have relative ocular sympathetic insufficiency.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>10708238</pmid><doi>10.1097/00061198-200002000-00016</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 1057-0829 |
| ispartof | Journal of glaucoma, 2000-02, Vol.9 (1), p.95-98 |
| issn | 1057-0829 1536-481X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Antihypertensive Agents - adverse effects Autonomic Nervous System Diseases - diagnosis Cocaine - administration & dosage Follow-Up Studies Glaucoma, Open-Angle - drug therapy Humans Intraocular Pressure - drug effects Iris - drug effects Iris - innervation Iris Diseases - chemically induced Iris Diseases - pathology Male Middle Aged Ophthalmic Solutions Pigmentation Disorders - chemically induced Pigmentation Disorders - pathology Prostaglandins F, Synthetic - adverse effects Pupil - drug effects Sympathetic Nervous System - pathology |
| title | Latanoprost-induced Iris Color Darkening: A Case Report With Long-term Follow-up |
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