Comparative analysis of expression profiling of early-stage carcinogenesis using nodule-in-nodule-type hepatocellular carcinoma
BACKGROUNDNodule-in-nodule-type hepatocellular carcinoma (NIN-HCC) is a useful model to illustrate the multi-step nature of hepatocarcinogenesis. To identify large-scale molecular change in early hepatocarcinogenesis, the expression profile of NIN-HCC was compared with those from three sets of indiv...
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| Veröffentlicht in: | European journal of gastroenterology & hepatology 2006-03, Vol.18 (3), p.239-247 |
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| container_title | European journal of gastroenterology & hepatology |
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| creator | Nam, Suk Woo Lee, Jong Heun Noh, Ji Heon Lee, Shi Nae Kim, Su Young Lee, Sug Hyung Park, Cheol Kyun Ahn, Young Min Park, Won Sang Yoo, Nam Jin Lee, Jung Young |
| description | BACKGROUNDNodule-in-nodule-type hepatocellular carcinoma (NIN-HCC) is a useful model to illustrate the multi-step nature of hepatocarcinogenesis. To identify large-scale molecular change in early hepatocarcinogenesis, the expression profile of NIN-HCC was compared with those from three sets of individual high-grade dysplastic nodules (HGDN) and grade 1 hepatocellular carcinomas.
METHODSWe compared expression profiles of inner grade 1 hepatocellular carcinoma nodules and peripheral HGDN in one case of NIN-HCC using spotted-oligonucleotide DNA microarray. The relevant outlier genes assumed to associate with early carcinogenesis in hepatocellular carcinoma were identified by comparative analysis of NIN-HCC and individual cases of HGDN and grade 1 hepatocellular carcinoma, respectively.
RESULTSFrom this analysis we extracted a total of 40 genes, consisting of 28 up-regulated genes and 12 downregulated genes, and more than a two-fold change in grade 1 hepatocellular carcinoma compared with HGDN.
CONCLUSIONWe assessed the expression profiles of pre-neoplastic lesions and grade 1 hepatocellular carcinoma using oligonucleotide microarray analysis and found high stringent outlier genes that are presumably directly involved in the transition from dysplastic nodule to the early stage of hepatocellular carcinoma by utilizing NIN-HCC. |
| doi_str_mv | 10.1097/00042737-200603000-00003 |
| format | Article |
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METHODSWe compared expression profiles of inner grade 1 hepatocellular carcinoma nodules and peripheral HGDN in one case of NIN-HCC using spotted-oligonucleotide DNA microarray. The relevant outlier genes assumed to associate with early carcinogenesis in hepatocellular carcinoma were identified by comparative analysis of NIN-HCC and individual cases of HGDN and grade 1 hepatocellular carcinoma, respectively.
RESULTSFrom this analysis we extracted a total of 40 genes, consisting of 28 up-regulated genes and 12 downregulated genes, and more than a two-fold change in grade 1 hepatocellular carcinoma compared with HGDN.
CONCLUSIONWe assessed the expression profiles of pre-neoplastic lesions and grade 1 hepatocellular carcinoma using oligonucleotide microarray analysis and found high stringent outlier genes that are presumably directly involved in the transition from dysplastic nodule to the early stage of hepatocellular carcinoma by utilizing NIN-HCC.</description><identifier>ISSN: 0954-691X</identifier><identifier>EISSN: 1473-5687</identifier><identifier>DOI: 10.1097/00042737-200603000-00003</identifier><identifier>PMID: 16462536</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Biological and medical sciences ; Carcinoma, Hepatocellular - genetics ; Carcinoma, Hepatocellular - pathology ; Disease Progression ; Focal Nodular Hyperplasia - genetics ; Focal Nodular Hyperplasia - pathology ; Gastroenterology. Liver. Pancreas. Abdomen ; Gene Expression Profiling - methods ; Gene Expression Regulation, Neoplastic ; Humans ; Liver - pathology ; Liver Neoplasms - genetics ; Liver Neoplasms - pathology ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Medical sciences ; Oligonucleotide Array Sequence Analysis - methods ; Precancerous Conditions - genetics ; Precancerous Conditions - pathology ; Tumors</subject><ispartof>European journal of gastroenterology & hepatology, 2006-03, Vol.18 (3), p.239-247</ispartof><rights>2006 Lippincott Williams & Wilkins, Inc.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4233-b7537b4758e02d61b19109078da5178d862f00d184f202ae5d34b5df48943df43</citedby><cites>FETCH-LOGICAL-c4233-b7537b4758e02d61b19109078da5178d862f00d184f202ae5d34b5df48943df43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17712761$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16462536$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nam, Suk Woo</creatorcontrib><creatorcontrib>Lee, Jong Heun</creatorcontrib><creatorcontrib>Noh, Ji Heon</creatorcontrib><creatorcontrib>Lee, Shi Nae</creatorcontrib><creatorcontrib>Kim, Su Young</creatorcontrib><creatorcontrib>Lee, Sug Hyung</creatorcontrib><creatorcontrib>Park, Cheol Kyun</creatorcontrib><creatorcontrib>Ahn, Young Min</creatorcontrib><creatorcontrib>Park, Won Sang</creatorcontrib><creatorcontrib>Yoo, Nam Jin</creatorcontrib><creatorcontrib>Lee, Jung Young</creatorcontrib><title>Comparative analysis of expression profiling of early-stage carcinogenesis using nodule-in-nodule-type hepatocellular carcinoma</title><title>European journal of gastroenterology & hepatology</title><addtitle>Eur J Gastroenterol Hepatol</addtitle><description>BACKGROUNDNodule-in-nodule-type hepatocellular carcinoma (NIN-HCC) is a useful model to illustrate the multi-step nature of hepatocarcinogenesis. To identify large-scale molecular change in early hepatocarcinogenesis, the expression profile of NIN-HCC was compared with those from three sets of individual high-grade dysplastic nodules (HGDN) and grade 1 hepatocellular carcinomas.
METHODSWe compared expression profiles of inner grade 1 hepatocellular carcinoma nodules and peripheral HGDN in one case of NIN-HCC using spotted-oligonucleotide DNA microarray. The relevant outlier genes assumed to associate with early carcinogenesis in hepatocellular carcinoma were identified by comparative analysis of NIN-HCC and individual cases of HGDN and grade 1 hepatocellular carcinoma, respectively.
RESULTSFrom this analysis we extracted a total of 40 genes, consisting of 28 up-regulated genes and 12 downregulated genes, and more than a two-fold change in grade 1 hepatocellular carcinoma compared with HGDN.
CONCLUSIONWe assessed the expression profiles of pre-neoplastic lesions and grade 1 hepatocellular carcinoma using oligonucleotide microarray analysis and found high stringent outlier genes that are presumably directly involved in the transition from dysplastic nodule to the early stage of hepatocellular carcinoma by utilizing NIN-HCC.</description><subject>Biological and medical sciences</subject><subject>Carcinoma, Hepatocellular - genetics</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Disease Progression</subject><subject>Focal Nodular Hyperplasia - genetics</subject><subject>Focal Nodular Hyperplasia - pathology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gene Expression Profiling - methods</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Liver - pathology</subject><subject>Liver Neoplasms - genetics</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>Oligonucleotide Array Sequence Analysis - methods</subject><subject>Precancerous Conditions - genetics</subject><subject>Precancerous Conditions - pathology</subject><subject>Tumors</subject><issn>0954-691X</issn><issn>1473-5687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1P3DAQhi1UxG6Bv4By6dHt-CN2cqxWlFZC6qVI3KJJMtk1eOPITgp76l9v9oNy6sEz9uh55_CYsUzAZwGl_QIAWlpluQQwoOYnnw-oM7YU2iqem8J-YEsoc81NKR4X7GNKTwDCKmEv2EIYbWSuzJL9WYXtgBFH95sy7NHvkktZ6DJ6HSKl5EKfDTF0zrt-fZhj9DueRlxT1mBsXB_W1NM-NaU904d28sRdz0-3cTdQtqEBx9CQ95PH-Jbc4hU779Anuj71S_bw7fbX6ju__3n3Y_X1njdaKsVrmytba5sXBLI1ohblLAJs0WIu5loY2QG0otCdBImUt0rXedvpotRqbuqSFce9TQwpReqqIbotxl0loNo7rd6cVv-cVgenc_TmGB2mekvte_AkcQY-nQBMDfouYt-49M5ZK6Q1Yub0kXsJfqSYnv30QrHaEPpxU_3vT9VfBNaQ7Q</recordid><startdate>200603</startdate><enddate>200603</enddate><creator>Nam, Suk Woo</creator><creator>Lee, Jong Heun</creator><creator>Noh, Ji Heon</creator><creator>Lee, Shi Nae</creator><creator>Kim, Su Young</creator><creator>Lee, Sug Hyung</creator><creator>Park, Cheol Kyun</creator><creator>Ahn, Young Min</creator><creator>Park, Won Sang</creator><creator>Yoo, Nam Jin</creator><creator>Lee, Jung Young</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200603</creationdate><title>Comparative analysis of expression profiling of early-stage carcinogenesis using nodule-in-nodule-type hepatocellular carcinoma</title><author>Nam, Suk Woo ; Lee, Jong Heun ; Noh, Ji Heon ; Lee, Shi Nae ; Kim, Su Young ; Lee, Sug Hyung ; Park, Cheol Kyun ; Ahn, Young Min ; Park, Won Sang ; Yoo, Nam Jin ; Lee, Jung Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4233-b7537b4758e02d61b19109078da5178d862f00d184f202ae5d34b5df48943df43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Biological and medical sciences</topic><topic>Carcinoma, Hepatocellular - genetics</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Disease Progression</topic><topic>Focal Nodular Hyperplasia - genetics</topic><topic>Focal Nodular Hyperplasia - pathology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gene Expression Profiling - methods</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Liver - pathology</topic><topic>Liver Neoplasms - genetics</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Medical sciences</topic><topic>Oligonucleotide Array Sequence Analysis - methods</topic><topic>Precancerous Conditions - genetics</topic><topic>Precancerous Conditions - pathology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nam, Suk Woo</creatorcontrib><creatorcontrib>Lee, Jong Heun</creatorcontrib><creatorcontrib>Noh, Ji Heon</creatorcontrib><creatorcontrib>Lee, Shi Nae</creatorcontrib><creatorcontrib>Kim, Su Young</creatorcontrib><creatorcontrib>Lee, Sug Hyung</creatorcontrib><creatorcontrib>Park, Cheol Kyun</creatorcontrib><creatorcontrib>Ahn, Young Min</creatorcontrib><creatorcontrib>Park, Won Sang</creatorcontrib><creatorcontrib>Yoo, Nam Jin</creatorcontrib><creatorcontrib>Lee, Jung Young</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>European journal of gastroenterology & hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nam, Suk Woo</au><au>Lee, Jong Heun</au><au>Noh, Ji Heon</au><au>Lee, Shi Nae</au><au>Kim, Su Young</au><au>Lee, Sug Hyung</au><au>Park, Cheol Kyun</au><au>Ahn, Young Min</au><au>Park, Won Sang</au><au>Yoo, Nam Jin</au><au>Lee, Jung Young</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative analysis of expression profiling of early-stage carcinogenesis using nodule-in-nodule-type hepatocellular carcinoma</atitle><jtitle>European journal of gastroenterology & hepatology</jtitle><addtitle>Eur J Gastroenterol Hepatol</addtitle><date>2006-03</date><risdate>2006</risdate><volume>18</volume><issue>3</issue><spage>239</spage><epage>247</epage><pages>239-247</pages><issn>0954-691X</issn><eissn>1473-5687</eissn><abstract>BACKGROUNDNodule-in-nodule-type hepatocellular carcinoma (NIN-HCC) is a useful model to illustrate the multi-step nature of hepatocarcinogenesis. To identify large-scale molecular change in early hepatocarcinogenesis, the expression profile of NIN-HCC was compared with those from three sets of individual high-grade dysplastic nodules (HGDN) and grade 1 hepatocellular carcinomas.
METHODSWe compared expression profiles of inner grade 1 hepatocellular carcinoma nodules and peripheral HGDN in one case of NIN-HCC using spotted-oligonucleotide DNA microarray. The relevant outlier genes assumed to associate with early carcinogenesis in hepatocellular carcinoma were identified by comparative analysis of NIN-HCC and individual cases of HGDN and grade 1 hepatocellular carcinoma, respectively.
RESULTSFrom this analysis we extracted a total of 40 genes, consisting of 28 up-regulated genes and 12 downregulated genes, and more than a two-fold change in grade 1 hepatocellular carcinoma compared with HGDN.
CONCLUSIONWe assessed the expression profiles of pre-neoplastic lesions and grade 1 hepatocellular carcinoma using oligonucleotide microarray analysis and found high stringent outlier genes that are presumably directly involved in the transition from dysplastic nodule to the early stage of hepatocellular carcinoma by utilizing NIN-HCC.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>16462536</pmid><doi>10.1097/00042737-200603000-00003</doi><tpages>9</tpages></addata></record> |
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| subjects | Biological and medical sciences Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Disease Progression Focal Nodular Hyperplasia - genetics Focal Nodular Hyperplasia - pathology Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic Humans Liver - pathology Liver Neoplasms - genetics Liver Neoplasms - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Oligonucleotide Array Sequence Analysis - methods Precancerous Conditions - genetics Precancerous Conditions - pathology Tumors |
| title | Comparative analysis of expression profiling of early-stage carcinogenesis using nodule-in-nodule-type hepatocellular carcinoma |
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