The effect of hyperbaric oxygen therapy on the adverse effects of octreotide on wound healing
OBJECTIVEOctreotide, a long-acting somatostatin analogue, has been used in the treatment of various disorders. Octreotide has significant detrimental impacts upon wound healing. We tested the hypothesis that hyperbaric oxygen therapy may overcome octreotide-mediated suppression of wound healing. DES...
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| Veröffentlicht in: | European journal of gastroenterology & hepatology 2004-05, Vol.16 (5), p.475-478 |
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| container_title | European journal of gastroenterology & hepatology |
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| creator | Yildiz, Senol Uluutku, Haldun Gunay, Alp Yildirim, I2smail Yildirim, Şukru Gurbuz, Ahmet Kemal |
| description | OBJECTIVEOctreotide, a long-acting somatostatin analogue, has been used in the treatment of various disorders. Octreotide has significant detrimental impacts upon wound healing. We tested the hypothesis that hyperbaric oxygen therapy may overcome octreotide-mediated suppression of wound healing.
DESIGNProspective, randomised, parallel-group animal study.
METHODSOperated rats were divided into four groups(1) controls, (2) octreotide therapy, (3) hyperbaric oxygen therapy and (4) combination of octreotide and hyperbaric oxygen therapy. Wound healing was assessed by breaking-strength measurements, hydroxyproline levels and fibrosis scores.
RESULTSOctreotide decreased the breaking-strength measurements, hydroxyproline levels and fibrosis scores to 72%, 88% and 55%, respectively, of the control group. In the combination group, hyperbaric oxygen therapy increased breaking-strength measurements and hydroxyproline levels to 137% and 126%, respectively, of the control group. In the combination group, hyperbaric oxygen therapy tended to increase the fibrosis scores to 111% of the control group, but without statistical significance.
CONCLUSIONHyperbaric oxygen therapy tends to reverse the octreotide-induced impairment of wound healing. |
| doi_str_mv | 10.1097/00042737-200405000-00007 |
| format | Article |
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DESIGNProspective, randomised, parallel-group animal study.
METHODSOperated rats were divided into four groups(1) controls, (2) octreotide therapy, (3) hyperbaric oxygen therapy and (4) combination of octreotide and hyperbaric oxygen therapy. Wound healing was assessed by breaking-strength measurements, hydroxyproline levels and fibrosis scores.
RESULTSOctreotide decreased the breaking-strength measurements, hydroxyproline levels and fibrosis scores to 72%, 88% and 55%, respectively, of the control group. In the combination group, hyperbaric oxygen therapy increased breaking-strength measurements and hydroxyproline levels to 137% and 126%, respectively, of the control group. In the combination group, hyperbaric oxygen therapy tended to increase the fibrosis scores to 111% of the control group, but without statistical significance.
CONCLUSIONHyperbaric oxygen therapy tends to reverse the octreotide-induced impairment of wound healing.</description><identifier>ISSN: 0954-691X</identifier><identifier>EISSN: 1473-5687</identifier><identifier>DOI: 10.1097/00042737-200405000-00007</identifier><identifier>PMID: 15097040</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Animals ; Biological and medical sciences ; Gastroenterology. Liver. Pancreas. Abdomen ; Hyperbaric Oxygenation ; Male ; Medical sciences ; Octreotide - adverse effects ; Random Allocation ; Rats ; Rats, Wistar ; Vasoconstrictor Agents - adverse effects ; Wound Healing - drug effects</subject><ispartof>European journal of gastroenterology & hepatology, 2004-05, Vol.16 (5), p.475-478</ispartof><rights>2004 Lippincott Williams & Wilkins, Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3867-9d055eafb6b6138527fa9a6c0c43170131705d68b81e113eeb9af9a618f568523</citedby><cites>FETCH-LOGICAL-c3867-9d055eafb6b6138527fa9a6c0c43170131705d68b81e113eeb9af9a618f568523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15678264$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15097040$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yildiz, Senol</creatorcontrib><creatorcontrib>Uluutku, Haldun</creatorcontrib><creatorcontrib>Gunay, Alp</creatorcontrib><creatorcontrib>Yildirim, I2smail</creatorcontrib><creatorcontrib>Yildirim, Şukru</creatorcontrib><creatorcontrib>Gurbuz, Ahmet Kemal</creatorcontrib><title>The effect of hyperbaric oxygen therapy on the adverse effects of octreotide on wound healing</title><title>European journal of gastroenterology & hepatology</title><addtitle>Eur J Gastroenterol Hepatol</addtitle><description>OBJECTIVEOctreotide, a long-acting somatostatin analogue, has been used in the treatment of various disorders. Octreotide has significant detrimental impacts upon wound healing. We tested the hypothesis that hyperbaric oxygen therapy may overcome octreotide-mediated suppression of wound healing.
DESIGNProspective, randomised, parallel-group animal study.
METHODSOperated rats were divided into four groups(1) controls, (2) octreotide therapy, (3) hyperbaric oxygen therapy and (4) combination of octreotide and hyperbaric oxygen therapy. Wound healing was assessed by breaking-strength measurements, hydroxyproline levels and fibrosis scores.
RESULTSOctreotide decreased the breaking-strength measurements, hydroxyproline levels and fibrosis scores to 72%, 88% and 55%, respectively, of the control group. In the combination group, hyperbaric oxygen therapy increased breaking-strength measurements and hydroxyproline levels to 137% and 126%, respectively, of the control group. In the combination group, hyperbaric oxygen therapy tended to increase the fibrosis scores to 111% of the control group, but without statistical significance.
CONCLUSIONHyperbaric oxygen therapy tends to reverse the octreotide-induced impairment of wound healing.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hyperbaric Oxygenation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Octreotide - adverse effects</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Vasoconstrictor Agents - adverse effects</subject><subject>Wound Healing - drug effects</subject><issn>0954-691X</issn><issn>1473-5687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kV1PwyAUhonRuDn9C4YbL6tQCrSXZvErWeLNTLwxDaWHtdqVBTpn_710H-qNF8Ahed6TwwNCmJJrSjJ5QwhJYslkFIeC8HCNwiLyCI1pIlnERSqP0ZhkPIlERl9H6Mz7d0KoZFSeohHloUtIjtHbvAIMxoDusDW46lfgCuVqje1Xv4AWdxU4teqx3ZZYlZ_g_CHih4zVnQPb1SUM0Mau2xJXoJq6XZyjE6MaDxf7c4Je7u_m08do9vzwNL2dRZqlQkZZSTgHZQpRCMpSHkujMiU00UmYl9Bh46VIi5QCpQygyJQJAE1NeCmP2QSlu77aWe8dmHzl6qVyfU5JPhjLD8byH2P51liIXu6iq3WxhPI3uFcUgKs9oLxWjXGq1bX_wwmZxiIJXLLjNrbpgqOPZr0Blw8muir_78fYNwvhguk</recordid><startdate>200405</startdate><enddate>200405</enddate><creator>Yildiz, Senol</creator><creator>Uluutku, Haldun</creator><creator>Gunay, Alp</creator><creator>Yildirim, I2smail</creator><creator>Yildirim, Şukru</creator><creator>Gurbuz, Ahmet Kemal</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200405</creationdate><title>The effect of hyperbaric oxygen therapy on the adverse effects of octreotide on wound healing</title><author>Yildiz, Senol ; Uluutku, Haldun ; Gunay, Alp ; Yildirim, I2smail ; Yildirim, Şukru ; Gurbuz, Ahmet Kemal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3867-9d055eafb6b6138527fa9a6c0c43170131705d68b81e113eeb9af9a618f568523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hyperbaric Oxygenation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Octreotide - adverse effects</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Vasoconstrictor Agents - adverse effects</topic><topic>Wound Healing - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yildiz, Senol</creatorcontrib><creatorcontrib>Uluutku, Haldun</creatorcontrib><creatorcontrib>Gunay, Alp</creatorcontrib><creatorcontrib>Yildirim, I2smail</creatorcontrib><creatorcontrib>Yildirim, Şukru</creatorcontrib><creatorcontrib>Gurbuz, Ahmet Kemal</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>European journal of gastroenterology & hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yildiz, Senol</au><au>Uluutku, Haldun</au><au>Gunay, Alp</au><au>Yildirim, I2smail</au><au>Yildirim, Şukru</au><au>Gurbuz, Ahmet Kemal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of hyperbaric oxygen therapy on the adverse effects of octreotide on wound healing</atitle><jtitle>European journal of gastroenterology & hepatology</jtitle><addtitle>Eur J Gastroenterol Hepatol</addtitle><date>2004-05</date><risdate>2004</risdate><volume>16</volume><issue>5</issue><spage>475</spage><epage>478</epage><pages>475-478</pages><issn>0954-691X</issn><eissn>1473-5687</eissn><abstract>OBJECTIVEOctreotide, a long-acting somatostatin analogue, has been used in the treatment of various disorders. Octreotide has significant detrimental impacts upon wound healing. We tested the hypothesis that hyperbaric oxygen therapy may overcome octreotide-mediated suppression of wound healing.
DESIGNProspective, randomised, parallel-group animal study.
METHODSOperated rats were divided into four groups(1) controls, (2) octreotide therapy, (3) hyperbaric oxygen therapy and (4) combination of octreotide and hyperbaric oxygen therapy. Wound healing was assessed by breaking-strength measurements, hydroxyproline levels and fibrosis scores.
RESULTSOctreotide decreased the breaking-strength measurements, hydroxyproline levels and fibrosis scores to 72%, 88% and 55%, respectively, of the control group. In the combination group, hyperbaric oxygen therapy increased breaking-strength measurements and hydroxyproline levels to 137% and 126%, respectively, of the control group. In the combination group, hyperbaric oxygen therapy tended to increase the fibrosis scores to 111% of the control group, but without statistical significance.
CONCLUSIONHyperbaric oxygen therapy tends to reverse the octreotide-induced impairment of wound healing.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>15097040</pmid><doi>10.1097/00042737-200405000-00007</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0954-691X |
| ispartof | European journal of gastroenterology & hepatology, 2004-05, Vol.16 (5), p.475-478 |
| issn | 0954-691X 1473-5687 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Biological and medical sciences Gastroenterology. Liver. Pancreas. Abdomen Hyperbaric Oxygenation Male Medical sciences Octreotide - adverse effects Random Allocation Rats Rats, Wistar Vasoconstrictor Agents - adverse effects Wound Healing - drug effects |
| title | The effect of hyperbaric oxygen therapy on the adverse effects of octreotide on wound healing |
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