SK&F 86002, a dual cytokine and eicosanoid inhibitor, attenuates endotoxin-induced cardiopulmonary dysfunction in the pig

Cytokines and eicosanoids are well documented important mediators of endotoxemia. Bicyclic imidazoles are a novel class of nonsteroidal anti-inflammatory compounds that display unique pharmacological profiles by reducing cytokine production and arachidonic acid metabolism. In this study, we evaluate...

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Veröffentlicht in:	Shock (Augusta, Ga.) Ga.), 1996-11, Vol.6 (5), p.357-364
Hauptverfasser:	Triplett, E A, Kruse-Elliott, K T, Hart, A P, Schram, B R, MacWilliams, P S, Cooley, A J, Clayton, M K, Darien, B J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Cytokines - biosynthesis Cytokines - drug effects Eicosanoids - biosynthesis Endotoxemia - drug therapy Endotoxemia - metabolism Endotoxemia - pathology Heart - drug effects Heart - physiopathology Imidazoles - pharmacology Lipopolysaccharides - toxicity Lung - blood supply Lung - drug effects Lung - physiopathology Peroxidase - drug effects Peroxidase - metabolism Stroke Volume - drug effects Swine Thiazoles - pharmacology Thromboxanes - biosynthesis Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - drug effects Vascular Resistance - drug effects
Online-Zugang:	Volltext
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