A comparison of two progestins on myocardial ischemia–reperfusion injury in ovariectomized monkeys receiving estrogen therapy

OBJECTIVEIt has been reported that the progestin medroxyprogesterone acetate (MPA), but not norethindrone acetate (NETA), inhibits the beneficial vascular effects of post-menopausal estrogen therapy, but their effects on the myocardium are unclear. The goal of this study is to compare the effects of...

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Veröffentlicht in:	Coronary artery disease 2005-08, Vol.16 (5), p.301-308
Hauptverfasser:	Suparto, Irma H, Koudy Williams, J, Fox, Jamie L, Vinten-Johansen, Jakob
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers - blood Blood Flow Velocity - drug effects Blood Pressure - drug effects Body Weight - drug effects Contraceptive Agents, Female - pharmacology Coronary Circulation - drug effects Disease Models, Animal Drug Interactions Estrogens - therapeutic use Estrogens, Conjugated (USP) - therapeutic use Ethinyl Estradiol - therapeutic use Female Haplorhini Heart Rate - drug effects Lipids - blood Medroxyprogesterone Acetate - pharmacology Myocardial Reperfusion Injury - drug therapy Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - physiopathology Neovascularization, Physiologic - drug effects Norethindrone - analogs & derivatives Norethindrone - pharmacology Ovariectomy Peroxidase - drug effects Progestins - pharmacology Research Design Stroke Volume - drug effects Vascular Resistance - drug effects
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