Genetic variation in dopaminergic pathways and short-term effectiveness of the nicotine patch

Polymorphisms in the dopamine D2 receptor (DRD2 C/T and DRD2 A/G) and in dopamine beta hydroxylase (DBH A/G) have been implicated in modulation of smoking and other reward-seeking behaviours. We hypothesized that these alleles would predict the outcome of nicotine patch therapy for smoking cessation...

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Veröffentlicht in:	Pharmacogenetics (London) 2004-02, Vol.14 (2), p.83-90
Hauptverfasser:	JOHNSTONE, Elaine C, YUDKIN, Patricia L, HEY, Kate, ROBERTS, Sarah J, WELCH, Sarah J, MURPHY, Michael F, GRIFFITHS, Sian E, WALTON, Robert T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Biotechnology Dopamine beta-Hydroxylase - genetics Female Fundamental and applied biological sciences. Psychology Gene therapy Genetic Variation Genotype Health. Pharmaceutical industry Humans Industrial applications and implications. Economical aspects Male Middle Aged Nicotine - administration & dosage Nicotine - adverse effects Odds Ratio Receptors, Dopamine D2 - genetics Signal Transduction Smoking Cessation - methods
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