Analysis of the antiepileptic phenyltriazine compound lamotrigine using gas chromatography with nitrogen phosphorus detection

A method is described for the determination of lamotrigine in serum or plasma, based on gas chromatography with nitrogen-phosphorus detection. The method requires minimal sample preparation. The drug is extracted from 1.0 ml of serum at pH 11 into butylacetate containing prazepam as internal standar...

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Veröffentlicht in:	Therapeutic drug monitoring 1997-08, Vol.19 (4), p.460-464
Hauptverfasser:	WATELLE, M, DEMEDTS, P, FRANCK, F, DE DEYN, P. P, WAUTERS, A, NEELS, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Anticonvulsants - blood Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Chromatography, Gas - methods General pharmacology Humans Lamotrigine Medical sciences Neuropharmacology Pharmacology. Drug treatments Regression Analysis Triazines - blood
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