A case report on drug screening of Nail clippings to detect prenatal drug exposure
In a case of a sudden infant death syndrome-related death of a 3-month-old infant, nail clippings were positive for cocaine by gas chromatography-mass spectroscopy analysis that revealed a prenatal exposure to the drug substance. In utero exposure to drugs has been investigated using amniotic fluid,...
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| Veröffentlicht in: | Therapeutic drug monitoring 1997-08, Vol.19 (4), p.386-389 |
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| container_title | Therapeutic drug monitoring |
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| creator | SKOPP, G PÖTSCH, L |
| description | In a case of a sudden infant death syndrome-related death of a 3-month-old infant, nail clippings were positive for cocaine by gas chromatography-mass spectroscopy analysis that revealed a prenatal exposure to the drug substance. In utero exposure to drugs has been investigated using amniotic fluid, neonatal urine, meconium, and hair samples. Nail analysis offers some advantage over hair analysis because of its continuous growth and persistence after delivery. Nail material is easy to sample in suitable amounts. Currently, the cocaine finding cannot be related to the underlying cause of death. However, this observation indicates that nail analysis may be a new and valuable tool to screen newborns for intrauterine drug exposure. In addition, it can help collect information on the prevalence of possible embryotoxic effects and the link to postnatal manifestations of different dysfunctions in infants who are born by drug abusing mothers. |
| doi_str_mv | 10.1097/00007691-199708000-00004 |
| format | Article |
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In utero exposure to drugs has been investigated using amniotic fluid, neonatal urine, meconium, and hair samples. Nail analysis offers some advantage over hair analysis because of its continuous growth and persistence after delivery. Nail material is easy to sample in suitable amounts. Currently, the cocaine finding cannot be related to the underlying cause of death. However, this observation indicates that nail analysis may be a new and valuable tool to screen newborns for intrauterine drug exposure. In addition, it can help collect information on the prevalence of possible embryotoxic effects and the link to postnatal manifestations of different dysfunctions in infants who are born by drug abusing mothers.</description><identifier>ISSN: 0163-4356</identifier><identifier>EISSN: 1536-3694</identifier><identifier>DOI: 10.1097/00007691-199708000-00004</identifier><identifier>PMID: 9263377</identifier><identifier>CODEN: TDMODV</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Analysis ; Biological and medical sciences ; Cocaine - analysis ; Drug addictions ; Female ; General pharmacology ; Humans ; Infant ; Male ; Mass Spectrometry ; Medical sciences ; Nails - chemistry ; Narcotics - analysis ; Pharmacology. Drug treatments ; Pregnancy ; Prenatal Exposure Delayed Effects ; Substance-Related Disorders ; Sudden Infant Death ; Toxicology ; Tricuspid Valve - abnormalities</subject><ispartof>Therapeutic drug monitoring, 1997-08, Vol.19 (4), p.386-389</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-aa2462e66ec854601d8bac93d7cf48469db70f3aa30f5c6802c124fef94dd5123</citedby><cites>FETCH-LOGICAL-c339t-aa2462e66ec854601d8bac93d7cf48469db70f3aa30f5c6802c124fef94dd5123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2776844$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9263377$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SKOPP, G</creatorcontrib><creatorcontrib>PÖTSCH, L</creatorcontrib><title>A case report on drug screening of Nail clippings to detect prenatal drug exposure</title><title>Therapeutic drug monitoring</title><addtitle>Ther Drug Monit</addtitle><description>In a case of a sudden infant death syndrome-related death of a 3-month-old infant, nail clippings were positive for cocaine by gas chromatography-mass spectroscopy analysis that revealed a prenatal exposure to the drug substance. 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In addition, it can help collect information on the prevalence of possible embryotoxic effects and the link to postnatal manifestations of different dysfunctions in infants who are born by drug abusing mothers.</description><subject>Analysis</subject><subject>Biological and medical sciences</subject><subject>Cocaine - analysis</subject><subject>Drug addictions</subject><subject>Female</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Mass Spectrometry</subject><subject>Medical sciences</subject><subject>Nails - chemistry</subject><subject>Narcotics - analysis</subject><subject>Pharmacology. Drug treatments</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Substance-Related Disorders</subject><subject>Sudden Infant Death</subject><subject>Toxicology</subject><subject>Tricuspid Valve - abnormalities</subject><issn>0163-4356</issn><issn>1536-3694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLAzEUhYMotVZ_gpCF22hek8eyFK1CURBdD2lyU0amMyGZgv57p7b2bi73nPPdxUEIM3rPqNUPdBytLCPMWk3NeJG9JM_QlFVCEaGsPEdTypQgUlTqEl2V8kUpk2N2giaWKyG0nqL3OfauAM6Q-jzgvsMh7za4-AzQNd0G9xG_uqbFvm1SGoWChx4HGMAPOGXo3ODaAwPfqS-7DNfoIrq2wM1xz9Dn0-PH4pms3pYvi_mKeCHsQJzjUnFQCryppKIsmLXzVgTtozRS2bDWNArnBI2VV4Zyz7iMEK0MoWJczJA5_PW5LyVDrFNuti7_1IzW-5bq_5bqU0t_khzR2wOadusthBN4rGX0746-K961MbvON-UU41orI6X4BZtfb3I</recordid><startdate>19970801</startdate><enddate>19970801</enddate><creator>SKOPP, G</creator><creator>PÖTSCH, L</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19970801</creationdate><title>A case report on drug screening of Nail clippings to detect prenatal drug exposure</title><author>SKOPP, G ; PÖTSCH, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-aa2462e66ec854601d8bac93d7cf48469db70f3aa30f5c6802c124fef94dd5123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Analysis</topic><topic>Biological and medical sciences</topic><topic>Cocaine - analysis</topic><topic>Drug addictions</topic><topic>Female</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Mass Spectrometry</topic><topic>Medical sciences</topic><topic>Nails - chemistry</topic><topic>Narcotics - analysis</topic><topic>Pharmacology. Drug treatments</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>Substance-Related Disorders</topic><topic>Sudden Infant Death</topic><topic>Toxicology</topic><topic>Tricuspid Valve - abnormalities</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SKOPP, G</creatorcontrib><creatorcontrib>PÖTSCH, L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Therapeutic drug monitoring</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SKOPP, G</au><au>PÖTSCH, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A case report on drug screening of Nail clippings to detect prenatal drug exposure</atitle><jtitle>Therapeutic drug monitoring</jtitle><addtitle>Ther Drug Monit</addtitle><date>1997-08-01</date><risdate>1997</risdate><volume>19</volume><issue>4</issue><spage>386</spage><epage>389</epage><pages>386-389</pages><issn>0163-4356</issn><eissn>1536-3694</eissn><coden>TDMODV</coden><abstract>In a case of a sudden infant death syndrome-related death of a 3-month-old infant, nail clippings were positive for cocaine by gas chromatography-mass spectroscopy analysis that revealed a prenatal exposure to the drug substance. In utero exposure to drugs has been investigated using amniotic fluid, neonatal urine, meconium, and hair samples. Nail analysis offers some advantage over hair analysis because of its continuous growth and persistence after delivery. Nail material is easy to sample in suitable amounts. Currently, the cocaine finding cannot be related to the underlying cause of death. However, this observation indicates that nail analysis may be a new and valuable tool to screen newborns for intrauterine drug exposure. In addition, it can help collect information on the prevalence of possible embryotoxic effects and the link to postnatal manifestations of different dysfunctions in infants who are born by drug abusing mothers.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>9263377</pmid><doi>10.1097/00007691-199708000-00004</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-4356 |
| ispartof | Therapeutic drug monitoring, 1997-08, Vol.19 (4), p.386-389 |
| issn | 0163-4356 1536-3694 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Analysis Biological and medical sciences Cocaine - analysis Drug addictions Female General pharmacology Humans Infant Male Mass Spectrometry Medical sciences Nails - chemistry Narcotics - analysis Pharmacology. Drug treatments Pregnancy Prenatal Exposure Delayed Effects Substance-Related Disorders Sudden Infant Death Toxicology Tricuspid Valve - abnormalities |
| title | A case report on drug screening of Nail clippings to detect prenatal drug exposure |
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