Individualizing amikacin regimens : accurate method to achieve therapeutic concentrations

Amikacin's pharmacokinetics and dosage requirements were studied in 98 patients receiving treatment for gram-negative infections. A wide interpatient variation in the kinetic parameters of the drug occurred in all patients and in patients who had normal serum creatinine levels or normal creatin...

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Veröffentlicht in:	Therapeutic drug monitoring 1991-11, Vol.13 (6), p.502-506
Hauptverfasser:	ZASKE, D. E, CIPOLLE, R. J, ROTSCHAFER, J. C, KOHLS, P. R, STRATE, R. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aging - metabolism Amikacin - administration & dosage Amikacin - adverse effects Amikacin - pharmacokinetics Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Dose-Response Relationship, Drug Drug Administration Schedule Female Genetic Variation - physiology Gram-Negative Bacterial Infections - drug therapy Gram-Negative Bacterial Infections - metabolism Humans Kidney - physiology Male Medical sciences Middle Aged Models, Biological Pharmacology. Drug treatments
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