Measurement of antidepressants using solid-phase extraction and wide-bore capillary gas chromatography with nitrogen-selective detection
A comprehensive method is presented for the determination of nine antidepressant drugs and metabolites in serum: (1) amitriptyline, (2) nortriptyline, (3) imipramine, (4) desipramine, (5) maprotiline, (6) doxepin, (7) desmethyldoxepin, (8) protriptyline, and (9) trimipramine. Chlorimipramine is used...
Gespeichert in:
| Veröffentlicht in: | Therapeutic drug monitoring 1988-01, Vol.10 (2), p.194-196 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 196 |
|---|---|
| container_issue | 2 |
| container_start_page | 194 |
| container_title | Therapeutic drug monitoring |
| container_volume | 10 |
| creator | RIFAI, N HOWLETT, C. M LEVTZOW, C. B PHILLIPS, J. C PARKER, N. C CROSS, R. E |
| description | A comprehensive method is presented for the determination of nine antidepressant drugs and metabolites in serum: (1) amitriptyline, (2) nortriptyline, (3) imipramine, (4) desipramine, (5) maprotiline, (6) doxepin, (7) desmethyldoxepin, (8) protriptyline, and (9) trimipramine. Chlorimipramine is used as the internal standard. A simple solid-phase extraction procedure utilizing disposable reversed-phase C18 columns is described. Samples are analyzed by gas chromatography with nitrogen-selective detection using a wide-bore capillary column with a permanently bonded, non-polar stationary phase. The assay possesses linearity to 800 ng/mL for maprotiline and 500 ng/mL for the other antidepressants, sensitivity to at least 25 ng/mL, recovery ranging from 96 to 107%, and between-run precision reflected by CVs of 4.4 to 8.1%. Lack of interference is documented for over 27 commonly prescribed drugs. We conclude that the method reported here is ideally suited for monitoring therapeutic and toxic levels of antidepressant drugs. |
| doi_str_mv | 10.1097/00007691-198802000-00014 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1097_00007691_198802000_00014</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3381238</sourcerecordid><originalsourceid>FETCH-LOGICAL-c339t-e45bfec5c5f2d761a202fabf41da99e737f5489716eeee29619da0f28307c69a3</originalsourceid><addsrcrecordid>eNo9kMtOwzAQRS0EKqXwCUhesDXYceLYS1TxkorYwDqaOuM2KE0i2wX6B3w27oOONBpbc-_V6BBCBb8V3JR3PFWpjGDCaM2z9GOpRX5CxqKQikll8lMy5kJJlstCnZOLED63Cs35iIyk1CKTekx-XxHC2uMKu0h7R6GLTY2DxxDSM9B1aLoFDX3b1GxYQkCKP9GDjU3fJXFNv5OczXuP1MLQtC34DV1AoHbp-xXEfuFhWG6SLC5p10TfL7BjAVtMEV9Ia4y4C7skZw7agFeHOSEfjw_v02c2e3t6md7PmJXSRIZ5MXdoC1u4rC6VgIxnDuYuFzUYg6UsXZFrUwqFqTKjhKmBu0xLXlplQE6I3uda34fg0VWDb1bp6krwasu2-mdbHdlWO7bJer23Duv5Cuuj8QAz7W8OewgWWuehs004ykqd5ekc-QeHq4Xk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Measurement of antidepressants using solid-phase extraction and wide-bore capillary gas chromatography with nitrogen-selective detection</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>RIFAI, N ; HOWLETT, C. M ; LEVTZOW, C. B ; PHILLIPS, J. C ; PARKER, N. C ; CROSS, R. E</creator><creatorcontrib>RIFAI, N ; HOWLETT, C. M ; LEVTZOW, C. B ; PHILLIPS, J. C ; PARKER, N. C ; CROSS, R. E</creatorcontrib><description>A comprehensive method is presented for the determination of nine antidepressant drugs and metabolites in serum: (1) amitriptyline, (2) nortriptyline, (3) imipramine, (4) desipramine, (5) maprotiline, (6) doxepin, (7) desmethyldoxepin, (8) protriptyline, and (9) trimipramine. Chlorimipramine is used as the internal standard. A simple solid-phase extraction procedure utilizing disposable reversed-phase C18 columns is described. Samples are analyzed by gas chromatography with nitrogen-selective detection using a wide-bore capillary column with a permanently bonded, non-polar stationary phase. The assay possesses linearity to 800 ng/mL for maprotiline and 500 ng/mL for the other antidepressants, sensitivity to at least 25 ng/mL, recovery ranging from 96 to 107%, and between-run precision reflected by CVs of 4.4 to 8.1%. Lack of interference is documented for over 27 commonly prescribed drugs. We conclude that the method reported here is ideally suited for monitoring therapeutic and toxic levels of antidepressant drugs.</description><identifier>ISSN: 0163-4356</identifier><identifier>EISSN: 1536-3694</identifier><identifier>DOI: 10.1097/00007691-198802000-00014</identifier><identifier>PMID: 3381238</identifier><identifier>CODEN: TDMODV</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Analysis ; Antidepressive Agents - blood ; Biological and medical sciences ; Chromatography, Gas ; General pharmacology ; Humans ; Medical sciences ; Pharmacology. Drug treatments</subject><ispartof>Therapeutic drug monitoring, 1988-01, Vol.10 (2), p.194-196</ispartof><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-e45bfec5c5f2d761a202fabf41da99e737f5489716eeee29619da0f28307c69a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7824619$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3381238$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RIFAI, N</creatorcontrib><creatorcontrib>HOWLETT, C. M</creatorcontrib><creatorcontrib>LEVTZOW, C. B</creatorcontrib><creatorcontrib>PHILLIPS, J. C</creatorcontrib><creatorcontrib>PARKER, N. C</creatorcontrib><creatorcontrib>CROSS, R. E</creatorcontrib><title>Measurement of antidepressants using solid-phase extraction and wide-bore capillary gas chromatography with nitrogen-selective detection</title><title>Therapeutic drug monitoring</title><addtitle>Ther Drug Monit</addtitle><description>A comprehensive method is presented for the determination of nine antidepressant drugs and metabolites in serum: (1) amitriptyline, (2) nortriptyline, (3) imipramine, (4) desipramine, (5) maprotiline, (6) doxepin, (7) desmethyldoxepin, (8) protriptyline, and (9) trimipramine. Chlorimipramine is used as the internal standard. A simple solid-phase extraction procedure utilizing disposable reversed-phase C18 columns is described. Samples are analyzed by gas chromatography with nitrogen-selective detection using a wide-bore capillary column with a permanently bonded, non-polar stationary phase. The assay possesses linearity to 800 ng/mL for maprotiline and 500 ng/mL for the other antidepressants, sensitivity to at least 25 ng/mL, recovery ranging from 96 to 107%, and between-run precision reflected by CVs of 4.4 to 8.1%. Lack of interference is documented for over 27 commonly prescribed drugs. We conclude that the method reported here is ideally suited for monitoring therapeutic and toxic levels of antidepressant drugs.</description><subject>Analysis</subject><subject>Antidepressive Agents - blood</subject><subject>Biological and medical sciences</subject><subject>Chromatography, Gas</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><issn>0163-4356</issn><issn>1536-3694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtOwzAQRS0EKqXwCUhesDXYceLYS1TxkorYwDqaOuM2KE0i2wX6B3w27oOONBpbc-_V6BBCBb8V3JR3PFWpjGDCaM2z9GOpRX5CxqKQikll8lMy5kJJlstCnZOLED63Cs35iIyk1CKTekx-XxHC2uMKu0h7R6GLTY2DxxDSM9B1aLoFDX3b1GxYQkCKP9GDjU3fJXFNv5OczXuP1MLQtC34DV1AoHbp-xXEfuFhWG6SLC5p10TfL7BjAVtMEV9Ia4y4C7skZw7agFeHOSEfjw_v02c2e3t6md7PmJXSRIZ5MXdoC1u4rC6VgIxnDuYuFzUYg6UsXZFrUwqFqTKjhKmBu0xLXlplQE6I3uda34fg0VWDb1bp6krwasu2-mdbHdlWO7bJer23Duv5Cuuj8QAz7W8OewgWWuehs004ykqd5ekc-QeHq4Xk</recordid><startdate>19880101</startdate><enddate>19880101</enddate><creator>RIFAI, N</creator><creator>HOWLETT, C. M</creator><creator>LEVTZOW, C. B</creator><creator>PHILLIPS, J. C</creator><creator>PARKER, N. C</creator><creator>CROSS, R. E</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19880101</creationdate><title>Measurement of antidepressants using solid-phase extraction and wide-bore capillary gas chromatography with nitrogen-selective detection</title><author>RIFAI, N ; HOWLETT, C. M ; LEVTZOW, C. B ; PHILLIPS, J. C ; PARKER, N. C ; CROSS, R. E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-e45bfec5c5f2d761a202fabf41da99e737f5489716eeee29619da0f28307c69a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Analysis</topic><topic>Antidepressive Agents - blood</topic><topic>Biological and medical sciences</topic><topic>Chromatography, Gas</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RIFAI, N</creatorcontrib><creatorcontrib>HOWLETT, C. M</creatorcontrib><creatorcontrib>LEVTZOW, C. B</creatorcontrib><creatorcontrib>PHILLIPS, J. C</creatorcontrib><creatorcontrib>PARKER, N. C</creatorcontrib><creatorcontrib>CROSS, R. E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Therapeutic drug monitoring</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RIFAI, N</au><au>HOWLETT, C. M</au><au>LEVTZOW, C. B</au><au>PHILLIPS, J. C</au><au>PARKER, N. C</au><au>CROSS, R. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Measurement of antidepressants using solid-phase extraction and wide-bore capillary gas chromatography with nitrogen-selective detection</atitle><jtitle>Therapeutic drug monitoring</jtitle><addtitle>Ther Drug Monit</addtitle><date>1988-01-01</date><risdate>1988</risdate><volume>10</volume><issue>2</issue><spage>194</spage><epage>196</epage><pages>194-196</pages><issn>0163-4356</issn><eissn>1536-3694</eissn><coden>TDMODV</coden><abstract>A comprehensive method is presented for the determination of nine antidepressant drugs and metabolites in serum: (1) amitriptyline, (2) nortriptyline, (3) imipramine, (4) desipramine, (5) maprotiline, (6) doxepin, (7) desmethyldoxepin, (8) protriptyline, and (9) trimipramine. Chlorimipramine is used as the internal standard. A simple solid-phase extraction procedure utilizing disposable reversed-phase C18 columns is described. Samples are analyzed by gas chromatography with nitrogen-selective detection using a wide-bore capillary column with a permanently bonded, non-polar stationary phase. The assay possesses linearity to 800 ng/mL for maprotiline and 500 ng/mL for the other antidepressants, sensitivity to at least 25 ng/mL, recovery ranging from 96 to 107%, and between-run precision reflected by CVs of 4.4 to 8.1%. Lack of interference is documented for over 27 commonly prescribed drugs. We conclude that the method reported here is ideally suited for monitoring therapeutic and toxic levels of antidepressant drugs.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>3381238</pmid><doi>10.1097/00007691-198802000-00014</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-4356 |
| ispartof | Therapeutic drug monitoring, 1988-01, Vol.10 (2), p.194-196 |
| issn | 0163-4356 1536-3694 |
| language | eng |
| recordid | cdi_crossref_primary_10_1097_00007691_198802000_00014 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Analysis Antidepressive Agents - blood Biological and medical sciences Chromatography, Gas General pharmacology Humans Medical sciences Pharmacology. Drug treatments |
| title | Measurement of antidepressants using solid-phase extraction and wide-bore capillary gas chromatography with nitrogen-selective detection |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T16%3A24%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Measurement%20of%20antidepressants%20using%20solid-phase%20extraction%20and%20wide-bore%20capillary%20gas%20chromatography%20with%20nitrogen-selective%20detection&rft.jtitle=Therapeutic%20drug%20monitoring&rft.au=RIFAI,%20N&rft.date=1988-01-01&rft.volume=10&rft.issue=2&rft.spage=194&rft.epage=196&rft.pages=194-196&rft.issn=0163-4356&rft.eissn=1536-3694&rft.coden=TDMODV&rft_id=info:doi/10.1097/00007691-198802000-00014&rft_dat=%3Cpubmed_cross%3E3381238%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/3381238&rfr_iscdi=true |