Osteogenic protein-1 overcomes the inhibitory effect of nicotine on posterolateral lumbar fusion
An established rabbit posterolateral lumbar fusion model was used to evaluate the ability of osteogenic protein-1 to overcome the inhibitory effect of nicotine. To determine whether osteogenic protein-1 should be considered as a bone graft alternative for the patient who smokes. Smoking interferes w...
Gespeichert in:
| Veröffentlicht in: | Spine (Philadelphia, Pa. 1976) Pa. 1976), 2001-08, Vol.26 (15), p.1656-1661 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1661 |
|---|---|
| container_issue | 15 |
| container_start_page | 1656 |
| container_title | Spine (Philadelphia, Pa. 1976) |
| container_volume | 26 |
| creator | PATEL, Tushar Ch ERULKAR, Jonathan S GRAUER, Jonathan N TROIANO, Nancy W PANJABI, Manohar M FRIEDLAENDER, Gary E |
| description | An established rabbit posterolateral lumbar fusion model was used to evaluate the ability of osteogenic protein-1 to overcome the inhibitory effect of nicotine.
To determine whether osteogenic protein-1 should be considered as a bone graft alternative for the patient who smokes.
Smoking interferes with the success of posterolateral lumbar fusion. This inhibitory effect has been attributed to nicotine and confirmed in a New Zealand white rabbit model. Osteoinductive protein-1 has been shown to induce posterolateral spine fusion reliably in the rabbit model. The effectiveness with which osteogenic protein-1 induces fusion in the presence of nicotine has not been studied previously.
Single-level posterolateral intertransverse process fusions were performed at L5-L6 in 18 New Zealand white rabbits. Either autograft or osteogenic protein-1 was used as grafting material. Nicotine was administered via subcutaneous mini-osmotic pumps. The animals were killed 5 weeks after surgery, and the resulting fusion masses were studied.
Three rabbits (17%) were excluded because of complications. By manual palpation, two of the eight nicotine-exposed autograft rabbits (25%) and all of the nicotine-exposed osteogenic protein-1 rabbits (100%) were found to be fused. These results correlated well with those obtained from biomechanical testing. Histologically, the fusion zones of the nicotine-exposed autograft rabbits were distinctly less mature than the fusion masses of the nicotine-exposed osteogenic protein-1 rabbits.
Osteoinductive protein-1 was able to overcome the inhibitory effects of nicotine in a rabbit posterolateral spine fusion model, and to induce bony fusion reliably at 5 weeks. |
| doi_str_mv | 10.1097/00007632-200108010-00004 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1097_00007632_200108010_00004</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>11474350</sourcerecordid><originalsourceid>FETCH-LOGICAL-c435t-4bd87416b2f5b235db658126096b829115c42ee889fbb00cb8d63fdaa5fa8d293</originalsourceid><addsrcrecordid>eNpNkNtKAzEQhoMotlZfQXLhbTSnzWYvpXiCQm_0ek2yiY3sJkuyFfr2ploPAzMDw_cPMz8AkOBrgpv6BpeoBaOIYkywLIn2I34E5qSiEhFSNcdgjpkoCGdiBs5yfi-EYKQ5BTNCeM1ZhefgdZ0nG99s8AaOKU7WB0Rg_LDJxMFmOG0s9GHjtZ9i2kHrnDUTjA4WQZx8sDAGOMayJMVelap62G8HrRJ02-xjOAcnTvXZXhz6Arzc3z0vH9Fq_fC0vF0hUw6ZENedrDkRmrpKU1Z1WlSSUIEboSVtykOGU2ulbJzWGBstO8Fcp1TllOxowxZAfu81KeacrGvH5AeVdi3B7d609se09te0rxEv0stv6bjVg-3-hAeXCnB1AFQ2qndJBePzP44IKiX7BIlddZk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Osteogenic protein-1 overcomes the inhibitory effect of nicotine on posterolateral lumbar fusion</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>PATEL, Tushar Ch ; ERULKAR, Jonathan S ; GRAUER, Jonathan N ; TROIANO, Nancy W ; PANJABI, Manohar M ; FRIEDLAENDER, Gary E</creator><creatorcontrib>PATEL, Tushar Ch ; ERULKAR, Jonathan S ; GRAUER, Jonathan N ; TROIANO, Nancy W ; PANJABI, Manohar M ; FRIEDLAENDER, Gary E</creatorcontrib><description>An established rabbit posterolateral lumbar fusion model was used to evaluate the ability of osteogenic protein-1 to overcome the inhibitory effect of nicotine.
To determine whether osteogenic protein-1 should be considered as a bone graft alternative for the patient who smokes.
Smoking interferes with the success of posterolateral lumbar fusion. This inhibitory effect has been attributed to nicotine and confirmed in a New Zealand white rabbit model. Osteoinductive protein-1 has been shown to induce posterolateral spine fusion reliably in the rabbit model. The effectiveness with which osteogenic protein-1 induces fusion in the presence of nicotine has not been studied previously.
Single-level posterolateral intertransverse process fusions were performed at L5-L6 in 18 New Zealand white rabbits. Either autograft or osteogenic protein-1 was used as grafting material. Nicotine was administered via subcutaneous mini-osmotic pumps. The animals were killed 5 weeks after surgery, and the resulting fusion masses were studied.
Three rabbits (17%) were excluded because of complications. By manual palpation, two of the eight nicotine-exposed autograft rabbits (25%) and all of the nicotine-exposed osteogenic protein-1 rabbits (100%) were found to be fused. These results correlated well with those obtained from biomechanical testing. Histologically, the fusion zones of the nicotine-exposed autograft rabbits were distinctly less mature than the fusion masses of the nicotine-exposed osteogenic protein-1 rabbits.
Osteoinductive protein-1 was able to overcome the inhibitory effects of nicotine in a rabbit posterolateral spine fusion model, and to induce bony fusion reliably at 5 weeks.</description><identifier>ISSN: 0362-2436</identifier><identifier>EISSN: 1528-1159</identifier><identifier>DOI: 10.1097/00007632-200108010-00004</identifier><identifier>PMID: 11474350</identifier><identifier>CODEN: SPINDD</identifier><language>eng</language><publisher>Philadelphia, PA: Lippincott</publisher><subject>Animals ; Biological and medical sciences ; Bone Morphogenetic Protein 7 ; Bone Morphogenetic Proteins - pharmacology ; Bone Transplantation ; Cotinine - blood ; Graft Survival - drug effects ; Lumbar Vertebrae - diagnostic imaging ; Lumbar Vertebrae - drug effects ; Lumbar Vertebrae - pathology ; Lumbar Vertebrae - surgery ; Medical sciences ; Models, Animal ; Nicotine - adverse effects ; Nicotine - blood ; Orthopedic surgery ; Rabbits ; Radiography ; Spinal Fusion ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Transforming Growth Factor beta</subject><ispartof>Spine (Philadelphia, Pa. 1976), 2001-08, Vol.26 (15), p.1656-1661</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-4bd87416b2f5b235db658126096b829115c42ee889fbb00cb8d63fdaa5fa8d293</citedby><cites>FETCH-LOGICAL-c435t-4bd87416b2f5b235db658126096b829115c42ee889fbb00cb8d63fdaa5fa8d293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1116288$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11474350$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PATEL, Tushar Ch</creatorcontrib><creatorcontrib>ERULKAR, Jonathan S</creatorcontrib><creatorcontrib>GRAUER, Jonathan N</creatorcontrib><creatorcontrib>TROIANO, Nancy W</creatorcontrib><creatorcontrib>PANJABI, Manohar M</creatorcontrib><creatorcontrib>FRIEDLAENDER, Gary E</creatorcontrib><title>Osteogenic protein-1 overcomes the inhibitory effect of nicotine on posterolateral lumbar fusion</title><title>Spine (Philadelphia, Pa. 1976)</title><addtitle>Spine (Phila Pa 1976)</addtitle><description>An established rabbit posterolateral lumbar fusion model was used to evaluate the ability of osteogenic protein-1 to overcome the inhibitory effect of nicotine.
To determine whether osteogenic protein-1 should be considered as a bone graft alternative for the patient who smokes.
Smoking interferes with the success of posterolateral lumbar fusion. This inhibitory effect has been attributed to nicotine and confirmed in a New Zealand white rabbit model. Osteoinductive protein-1 has been shown to induce posterolateral spine fusion reliably in the rabbit model. The effectiveness with which osteogenic protein-1 induces fusion in the presence of nicotine has not been studied previously.
Single-level posterolateral intertransverse process fusions were performed at L5-L6 in 18 New Zealand white rabbits. Either autograft or osteogenic protein-1 was used as grafting material. Nicotine was administered via subcutaneous mini-osmotic pumps. The animals were killed 5 weeks after surgery, and the resulting fusion masses were studied.
Three rabbits (17%) were excluded because of complications. By manual palpation, two of the eight nicotine-exposed autograft rabbits (25%) and all of the nicotine-exposed osteogenic protein-1 rabbits (100%) were found to be fused. These results correlated well with those obtained from biomechanical testing. Histologically, the fusion zones of the nicotine-exposed autograft rabbits were distinctly less mature than the fusion masses of the nicotine-exposed osteogenic protein-1 rabbits.
Osteoinductive protein-1 was able to overcome the inhibitory effects of nicotine in a rabbit posterolateral spine fusion model, and to induce bony fusion reliably at 5 weeks.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bone Morphogenetic Protein 7</subject><subject>Bone Morphogenetic Proteins - pharmacology</subject><subject>Bone Transplantation</subject><subject>Cotinine - blood</subject><subject>Graft Survival - drug effects</subject><subject>Lumbar Vertebrae - diagnostic imaging</subject><subject>Lumbar Vertebrae - drug effects</subject><subject>Lumbar Vertebrae - pathology</subject><subject>Lumbar Vertebrae - surgery</subject><subject>Medical sciences</subject><subject>Models, Animal</subject><subject>Nicotine - adverse effects</subject><subject>Nicotine - blood</subject><subject>Orthopedic surgery</subject><subject>Rabbits</subject><subject>Radiography</subject><subject>Spinal Fusion</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Transforming Growth Factor beta</subject><issn>0362-2436</issn><issn>1528-1159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkNtKAzEQhoMotlZfQXLhbTSnzWYvpXiCQm_0ek2yiY3sJkuyFfr2ploPAzMDw_cPMz8AkOBrgpv6BpeoBaOIYkywLIn2I34E5qSiEhFSNcdgjpkoCGdiBs5yfi-EYKQ5BTNCeM1ZhefgdZ0nG99s8AaOKU7WB0Rg_LDJxMFmOG0s9GHjtZ9i2kHrnDUTjA4WQZx8sDAGOMayJMVelap62G8HrRJ02-xjOAcnTvXZXhz6Arzc3z0vH9Fq_fC0vF0hUw6ZENedrDkRmrpKU1Z1WlSSUIEboSVtykOGU2ulbJzWGBstO8Fcp1TllOxowxZAfu81KeacrGvH5AeVdi3B7d609se09te0rxEv0stv6bjVg-3-hAeXCnB1AFQ2qndJBePzP44IKiX7BIlddZk</recordid><startdate>20010801</startdate><enddate>20010801</enddate><creator>PATEL, Tushar Ch</creator><creator>ERULKAR, Jonathan S</creator><creator>GRAUER, Jonathan N</creator><creator>TROIANO, Nancy W</creator><creator>PANJABI, Manohar M</creator><creator>FRIEDLAENDER, Gary E</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20010801</creationdate><title>Osteogenic protein-1 overcomes the inhibitory effect of nicotine on posterolateral lumbar fusion</title><author>PATEL, Tushar Ch ; ERULKAR, Jonathan S ; GRAUER, Jonathan N ; TROIANO, Nancy W ; PANJABI, Manohar M ; FRIEDLAENDER, Gary E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-4bd87416b2f5b235db658126096b829115c42ee889fbb00cb8d63fdaa5fa8d293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bone Morphogenetic Protein 7</topic><topic>Bone Morphogenetic Proteins - pharmacology</topic><topic>Bone Transplantation</topic><topic>Cotinine - blood</topic><topic>Graft Survival - drug effects</topic><topic>Lumbar Vertebrae - diagnostic imaging</topic><topic>Lumbar Vertebrae - drug effects</topic><topic>Lumbar Vertebrae - pathology</topic><topic>Lumbar Vertebrae - surgery</topic><topic>Medical sciences</topic><topic>Models, Animal</topic><topic>Nicotine - adverse effects</topic><topic>Nicotine - blood</topic><topic>Orthopedic surgery</topic><topic>Rabbits</topic><topic>Radiography</topic><topic>Spinal Fusion</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Transforming Growth Factor beta</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PATEL, Tushar Ch</creatorcontrib><creatorcontrib>ERULKAR, Jonathan S</creatorcontrib><creatorcontrib>GRAUER, Jonathan N</creatorcontrib><creatorcontrib>TROIANO, Nancy W</creatorcontrib><creatorcontrib>PANJABI, Manohar M</creatorcontrib><creatorcontrib>FRIEDLAENDER, Gary E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Spine (Philadelphia, Pa. 1976)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PATEL, Tushar Ch</au><au>ERULKAR, Jonathan S</au><au>GRAUER, Jonathan N</au><au>TROIANO, Nancy W</au><au>PANJABI, Manohar M</au><au>FRIEDLAENDER, Gary E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Osteogenic protein-1 overcomes the inhibitory effect of nicotine on posterolateral lumbar fusion</atitle><jtitle>Spine (Philadelphia, Pa. 1976)</jtitle><addtitle>Spine (Phila Pa 1976)</addtitle><date>2001-08-01</date><risdate>2001</risdate><volume>26</volume><issue>15</issue><spage>1656</spage><epage>1661</epage><pages>1656-1661</pages><issn>0362-2436</issn><eissn>1528-1159</eissn><coden>SPINDD</coden><abstract>An established rabbit posterolateral lumbar fusion model was used to evaluate the ability of osteogenic protein-1 to overcome the inhibitory effect of nicotine.
To determine whether osteogenic protein-1 should be considered as a bone graft alternative for the patient who smokes.
Smoking interferes with the success of posterolateral lumbar fusion. This inhibitory effect has been attributed to nicotine and confirmed in a New Zealand white rabbit model. Osteoinductive protein-1 has been shown to induce posterolateral spine fusion reliably in the rabbit model. The effectiveness with which osteogenic protein-1 induces fusion in the presence of nicotine has not been studied previously.
Single-level posterolateral intertransverse process fusions were performed at L5-L6 in 18 New Zealand white rabbits. Either autograft or osteogenic protein-1 was used as grafting material. Nicotine was administered via subcutaneous mini-osmotic pumps. The animals were killed 5 weeks after surgery, and the resulting fusion masses were studied.
Three rabbits (17%) were excluded because of complications. By manual palpation, two of the eight nicotine-exposed autograft rabbits (25%) and all of the nicotine-exposed osteogenic protein-1 rabbits (100%) were found to be fused. These results correlated well with those obtained from biomechanical testing. Histologically, the fusion zones of the nicotine-exposed autograft rabbits were distinctly less mature than the fusion masses of the nicotine-exposed osteogenic protein-1 rabbits.
Osteoinductive protein-1 was able to overcome the inhibitory effects of nicotine in a rabbit posterolateral spine fusion model, and to induce bony fusion reliably at 5 weeks.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>11474350</pmid><doi>10.1097/00007632-200108010-00004</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0362-2436 |
| ispartof | Spine (Philadelphia, Pa. 1976), 2001-08, Vol.26 (15), p.1656-1661 |
| issn | 0362-2436 1528-1159 |
| language | eng |
| recordid | cdi_crossref_primary_10_1097_00007632_200108010_00004 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Biological and medical sciences Bone Morphogenetic Protein 7 Bone Morphogenetic Proteins - pharmacology Bone Transplantation Cotinine - blood Graft Survival - drug effects Lumbar Vertebrae - diagnostic imaging Lumbar Vertebrae - drug effects Lumbar Vertebrae - pathology Lumbar Vertebrae - surgery Medical sciences Models, Animal Nicotine - adverse effects Nicotine - blood Orthopedic surgery Rabbits Radiography Spinal Fusion Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Transforming Growth Factor beta |
| title | Osteogenic protein-1 overcomes the inhibitory effect of nicotine on posterolateral lumbar fusion |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-13T11%3A52%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Osteogenic%20protein-1%20overcomes%20the%20inhibitory%20effect%20of%20nicotine%20on%20posterolateral%20lumbar%20fusion&rft.jtitle=Spine%20(Philadelphia,%20Pa.%201976)&rft.au=PATEL,%20Tushar%20Ch&rft.date=2001-08-01&rft.volume=26&rft.issue=15&rft.spage=1656&rft.epage=1661&rft.pages=1656-1661&rft.issn=0362-2436&rft.eissn=1528-1159&rft.coden=SPINDD&rft_id=info:doi/10.1097/00007632-200108010-00004&rft_dat=%3Cpubmed_cross%3E11474350%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/11474350&rfr_iscdi=true |