Diaphragm-like strictures of the ileum associated with NSAID use : A rare complication
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed for many conditions including arthritis. A rare complication of their use is diaphragm-like strictures of the small and large intestines. A 65-year-old woman with a 12-year history of arthritis came to us with a 35-pound weight loss...
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| Veröffentlicht in: | Southern medical journal (Birmingham, Ala.) Ala.), 1998-04, Vol.91 (4), p.395-397 |
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| container_title | Southern medical journal (Birmingham, Ala.) |
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| creator | ABRAHAMIAN, G. A POLHAMUS, C. D MUSKAT, P KARULF, R. E |
| description | Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed for many conditions including arthritis. A rare complication of their use is diaphragm-like strictures of the small and large intestines. A 65-year-old woman with a 12-year history of arthritis came to us with a 35-pound weight loss and anorexia. She had been taking piroxicam for 3 years. Evaluation including enteroclysis revealed multiple mid-ileal diaphragm-like strictures and proximal small bowel dilatation. The symptoms persisted despite discontinuance of the drug. Abdominal exploration with intraoperative enteroscopy revealed five ileal strictures within a short segment of bowel. Resection was done and completion enteroscopy showed no other strictures. The patient recovered uneventfully and had full resolution of the symptoms. We discuss the difficulties in diagnosis and management of this drug complication and briefly review the literature. |
| doi_str_mv | 10.1097/00007611-199804000-00018 |
| format | Article |
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We discuss the difficulties in diagnosis and management of this drug complication and briefly review the literature.</description><identifier>ISSN: 0038-4348</identifier><identifier>EISSN: 1541-8243</identifier><identifier>DOI: 10.1097/00007611-199804000-00018</identifier><identifier>PMID: 9563437</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Aged ; Anti-Inflammatory Agents, Non-Steroidal - adverse effects ; Biological and medical sciences ; Constriction, Pathologic - chemically induced ; Drug toxicity and drugs side effects treatment ; Female ; Humans ; Ileal Diseases - chemically induced ; Ileal Diseases - diagnosis ; Intestinal Obstruction - chemically induced ; Intestinal Obstruction - diagnosis ; Medical sciences ; Pharmacology. 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D</creatorcontrib><creatorcontrib>MUSKAT, P</creatorcontrib><creatorcontrib>KARULF, R. E</creatorcontrib><title>Diaphragm-like strictures of the ileum associated with NSAID use : A rare complication</title><title>Southern medical journal (Birmingham, Ala.)</title><addtitle>South Med J</addtitle><description>Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed for many conditions including arthritis. A rare complication of their use is diaphragm-like strictures of the small and large intestines. A 65-year-old woman with a 12-year history of arthritis came to us with a 35-pound weight loss and anorexia. She had been taking piroxicam for 3 years. Evaluation including enteroclysis revealed multiple mid-ileal diaphragm-like strictures and proximal small bowel dilatation. The symptoms persisted despite discontinuance of the drug. Abdominal exploration with intraoperative enteroscopy revealed five ileal strictures within a short segment of bowel. Resection was done and completion enteroscopy showed no other strictures. The patient recovered uneventfully and had full resolution of the symptoms. We discuss the difficulties in diagnosis and management of this drug complication and briefly review the literature.</description><subject>Aged</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Constriction, Pathologic - chemically induced</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>Humans</subject><subject>Ileal Diseases - chemically induced</subject><subject>Ileal Diseases - diagnosis</subject><subject>Intestinal Obstruction - chemically induced</subject><subject>Intestinal Obstruction - diagnosis</subject><subject>Medical sciences</subject><subject>Pharmacology. 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A</creatorcontrib><creatorcontrib>POLHAMUS, C. D</creatorcontrib><creatorcontrib>MUSKAT, P</creatorcontrib><creatorcontrib>KARULF, R. E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Southern medical journal (Birmingham, Ala.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ABRAHAMIAN, G. A</au><au>POLHAMUS, C. D</au><au>MUSKAT, P</au><au>KARULF, R. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diaphragm-like strictures of the ileum associated with NSAID use : A rare complication</atitle><jtitle>Southern medical journal (Birmingham, Ala.)</jtitle><addtitle>South Med J</addtitle><date>1998-04-01</date><risdate>1998</risdate><volume>91</volume><issue>4</issue><spage>395</spage><epage>397</epage><pages>395-397</pages><issn>0038-4348</issn><eissn>1541-8243</eissn><abstract>Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed for many conditions including arthritis. A rare complication of their use is diaphragm-like strictures of the small and large intestines. A 65-year-old woman with a 12-year history of arthritis came to us with a 35-pound weight loss and anorexia. She had been taking piroxicam for 3 years. Evaluation including enteroclysis revealed multiple mid-ileal diaphragm-like strictures and proximal small bowel dilatation. The symptoms persisted despite discontinuance of the drug. Abdominal exploration with intraoperative enteroscopy revealed five ileal strictures within a short segment of bowel. Resection was done and completion enteroscopy showed no other strictures. The patient recovered uneventfully and had full resolution of the symptoms. We discuss the difficulties in diagnosis and management of this drug complication and briefly review the literature.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>9563437</pmid><doi>10.1097/00007611-199804000-00018</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0038-4348 |
| ispartof | Southern medical journal (Birmingham, Ala.), 1998-04, Vol.91 (4), p.395-397 |
| issn | 0038-4348 1541-8243 |
| language | eng |
| recordid | cdi_crossref_primary_10_1097_00007611_199804000_00018 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Aged Anti-Inflammatory Agents, Non-Steroidal - adverse effects Biological and medical sciences Constriction, Pathologic - chemically induced Drug toxicity and drugs side effects treatment Female Humans Ileal Diseases - chemically induced Ileal Diseases - diagnosis Intestinal Obstruction - chemically induced Intestinal Obstruction - diagnosis Medical sciences Pharmacology. Drug treatments Toxicity: digestive system |
| title | Diaphragm-like strictures of the ileum associated with NSAID use : A rare complication |
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