Redox-mediated enrichment of self-renewing adult human pancreatic cells that possess endocrine differentiation potential

The limited availability of transplantable human islets has stimulated the development of methods needed to isolate adult pancreatic stem/progenitor cells capable of self-renewal and endocrine differentiation. The objective of this study was to determine whether modulation of intracellular redox sta...

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Veröffentlicht in:	Pancreas 2004-10, Vol.29 (3), p.e64-e76
Hauptverfasser:	Linning, Katrina D, Tai, Mei-Hui, Madhukar, Burra V, Chang, C C, Reed, Jr, Donald N, Ferber, Sarah, Trosko, James E, Olson, L Karl
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Adenoviridae - genetics Adult Albumins - biosynthesis Albumins - genetics alpha-Amylases - biosynthesis alpha-Amylases - genetics C-Peptide - biosynthesis C-Peptide - genetics Cell Aggregation Cell Differentiation - drug effects Cell Separation Cells, Cultured - cytology Chromones - pharmacology Culture Media - pharmacology Culture Media, Serum-Free Exenatide Gene Expression Regulation - drug effects Genetic Vectors - genetics Genetic Vectors - pharmacology Glucagon - biosynthesis Glucagon - genetics Homeodomain Proteins - biosynthesis Homeodomain Proteins - genetics Humans Insulin - biosynthesis Insulin - genetics Intermediate Filament Proteins - biosynthesis Intermediate Filament Proteins - genetics Intracellular Fluid - metabolism Islets of Langerhans - cytology Morpholines - pharmacology Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Nestin Niacinamide - pharmacology Oxidation-Reduction Peptides - pharmacology Recombinant Fusion Proteins - genetics Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis RNA, Messenger - genetics Somatostatin - biosynthesis Somatostatin - genetics Stem Cells - cytology Stem Cells - drug effects Stem Cells - metabolism Trans-Activators - biosynthesis Trans-Activators - genetics Transcription Factors - biosynthesis Transcription Factors - genetics Venoms - pharmacology Vimentin - biosynthesis Vimentin - genetics
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