Involvement of calmodulin and protein kinase C in Cholecystokinin release by bombesin from STC-1 cells

The mouse intestinal neuroendocrine tumor cell line STC-1 secretes cholecystokinin (CCK) and other hormones. We investigated the role of Ca2+, calmodulin (CaM), and protein kinase C (PKC) in the regulation of CCK release from STC-1 cells. Phorbol 12-myristate 13-acetate (TPA) significantly stimulate...

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Veröffentlicht in:	Pancreas 2000-10, Vol.21 (3), p.231-239
Hauptverfasser:	TAKAHASHI, Akira, TANAKA, Shigeki, MIWA, Yoshikatsu, YOSHIDA, Hitoshi, IKEGAMI, Akitoshi, NIIKAWA, Junichi, MITAMURA, Keiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bombesin - pharmacology Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors Calcium-Calmodulin-Dependent Protein Kinases - metabolism Calmodulin - physiology Cholecystokinin - metabolism Digestive system Enzyme Activation Enzyme Inhibitors - pharmacology Intestinal Neoplasms - metabolism Investigative techniques, diagnostic techniques (general aspects) Medical sciences Mice Neuroendocrine Tumors - metabolism Neurotensin - pharmacology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Protein Kinase C - antagonists & inhibitors Protein Kinase C - physiology Sulfonamides - pharmacology Tetradecanoylphorbol Acetate - pharmacology Tumor Cells, Cultured
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