Effects of External Beam Irradiation on the TRAM Flap: An Experimental Model
The rat model of the transverse rectus abdominis musculocutaneous (TRAM) flap was used in the present study to determine the effects of external beam radiation on myocutaneous flap histology and pathophysiology. A total of 57 adult Sprague-Dawley rats underwent a TRAM procedure. A pilot study with 1...
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Veröffentlicht in: | Plastic and reconstructive surgery (1963) 2001-04, Vol.107 (5), p.1190-1197 |
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container_title | Plastic and reconstructive surgery (1963) |
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creator | Lin, Kant Y Patterson, James W Simmons, Joshua Long, Millie D Schultz, Raymond O Amiss, L R Molloy, Janelle A Kelly, Maria D |
description | The rat model of the transverse rectus abdominis musculocutaneous (TRAM) flap was used in the present study to determine the effects of external beam radiation on myocutaneous flap histology and pathophysiology. A total of 57 adult Sprague-Dawley rats underwent a TRAM procedure. A pilot study with 17 animals was first performed to determine proper radiation dosages, and the remaining 40 rats were then used in the definitive study. In half of the definitive study group, the flaps were subjected to fractionated doses of external beam radiation, whereas the other half served as controls. Six weeks after the last radiation dose, all animals were killed and the flaps were harvested for mechanical assessment and histopathologic evaluation. All TRAM flaps survived in both groups. The irradiated and nonirradiated flaps were minimally distinguishable in viscoelastic properties, as well as by histopathologic examination. Growth of the flap in the irradiated animals was significantly diminished (48 percent average surface area increase in irradiated flaps, versus 92 percent increase in nonirradiated flaps, p < 0.05). These findings suggest that the myocutaneous flap is relatively resistant to some of the known adverse affects of radiation on living tissues. (Plast. Reconstr. Surg. 1071190, 2001.) |
doi_str_mv | 10.1097/00006534-200104150-00014 |
format | Article |
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A total of 57 adult Sprague-Dawley rats underwent a TRAM procedure. A pilot study with 17 animals was first performed to determine proper radiation dosages, and the remaining 40 rats were then used in the definitive study. In half of the definitive study group, the flaps were subjected to fractionated doses of external beam radiation, whereas the other half served as controls. Six weeks after the last radiation dose, all animals were killed and the flaps were harvested for mechanical assessment and histopathologic evaluation. All TRAM flaps survived in both groups. The irradiated and nonirradiated flaps were minimally distinguishable in viscoelastic properties, as well as by histopathologic examination. Growth of the flap in the irradiated animals was significantly diminished (48 percent average surface area increase in irradiated flaps, versus 92 percent increase in nonirradiated flaps, p < 0.05). These findings suggest that the myocutaneous flap is relatively resistant to some of the known adverse affects of radiation on living tissues. (Plast. Reconstr. Surg. 1071190, 2001.)</description><identifier>ISSN: 0032-1052</identifier><identifier>EISSN: 1529-4242</identifier><identifier>DOI: 10.1097/00006534-200104150-00014</identifier><identifier>PMID: 11373560</identifier><language>eng</language><publisher>United States: American Society of Plastic Surgeons</publisher><subject>Animals ; Female ; Radiation Dosage ; Radiation Injuries, Experimental - pathology ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Surgical Flaps</subject><ispartof>Plastic and reconstructive surgery (1963), 2001-04, Vol.107 (5), p.1190-1197</ispartof><rights>2001American Society of Plastic Surgeons</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3564-ed6e721a4f80e8de49bbf67ca7f786f39c98c70caa3875c57de041e016321dec3</citedby><cites>FETCH-LOGICAL-c3564-ed6e721a4f80e8de49bbf67ca7f786f39c98c70caa3875c57de041e016321dec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11373560$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Kant Y</creatorcontrib><creatorcontrib>Patterson, James W</creatorcontrib><creatorcontrib>Simmons, Joshua</creatorcontrib><creatorcontrib>Long, Millie D</creatorcontrib><creatorcontrib>Schultz, Raymond O</creatorcontrib><creatorcontrib>Amiss, L R</creatorcontrib><creatorcontrib>Molloy, Janelle A</creatorcontrib><creatorcontrib>Kelly, Maria D</creatorcontrib><title>Effects of External Beam Irradiation on the TRAM Flap: An Experimental Model</title><title>Plastic and reconstructive surgery (1963)</title><addtitle>Plast Reconstr Surg</addtitle><description>The rat model of the transverse rectus abdominis musculocutaneous (TRAM) flap was used in the present study to determine the effects of external beam radiation on myocutaneous flap histology and pathophysiology. A total of 57 adult Sprague-Dawley rats underwent a TRAM procedure. A pilot study with 17 animals was first performed to determine proper radiation dosages, and the remaining 40 rats were then used in the definitive study. In half of the definitive study group, the flaps were subjected to fractionated doses of external beam radiation, whereas the other half served as controls. Six weeks after the last radiation dose, all animals were killed and the flaps were harvested for mechanical assessment and histopathologic evaluation. All TRAM flaps survived in both groups. The irradiated and nonirradiated flaps were minimally distinguishable in viscoelastic properties, as well as by histopathologic examination. Growth of the flap in the irradiated animals was significantly diminished (48 percent average surface area increase in irradiated flaps, versus 92 percent increase in nonirradiated flaps, p < 0.05). These findings suggest that the myocutaneous flap is relatively resistant to some of the known adverse affects of radiation on living tissues. (Plast. Reconstr. Surg. 1071190, 2001.)</description><subject>Animals</subject><subject>Female</subject><subject>Radiation Dosage</subject><subject>Radiation Injuries, Experimental - pathology</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Surgical Flaps</subject><issn>0032-1052</issn><issn>1529-4242</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kNtKw0AQhhdRbKy-guwLRGdP2cS7WlottAhSr5ftZpZW0yRsUqpv72qrXjkMDAz_P4ePEMrghkGhbyFGpoRMOQADyRSkscPkCUmY4kUqueSnJAEQPGWg-IBcdN1rVGiRqXMyYExooTJIyHziPbq-o42nk_ceQ20reo92S2ch2HJj-01T05j9GunyebSg08q2d3RUR3mLYbPFuo-WRVNidUnOvK06vDrWIXmZTpbjx3T-9DAbj-api0tlimWGmjMrfQ6YlyiL1cpn2lntdZ55UbgidxqctSLXyildYvwRgWWCsxKdGJL8MNeFpusCetPGQ2z4MAzMFyDzA8j8AjLfgKL1-mBtd6stln_GI5EokAfBvqkiju6t2u0xmDXaql-b_8CLT4E_bv4</recordid><startdate>20010415</startdate><enddate>20010415</enddate><creator>Lin, Kant Y</creator><creator>Patterson, James W</creator><creator>Simmons, Joshua</creator><creator>Long, Millie D</creator><creator>Schultz, Raymond O</creator><creator>Amiss, L R</creator><creator>Molloy, Janelle A</creator><creator>Kelly, Maria D</creator><general>American Society of Plastic Surgeons</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20010415</creationdate><title>Effects of External Beam Irradiation on the TRAM Flap: An Experimental Model</title><author>Lin, Kant Y ; Patterson, James W ; Simmons, Joshua ; Long, Millie D ; Schultz, Raymond O ; Amiss, L R ; Molloy, Janelle A ; Kelly, Maria D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3564-ed6e721a4f80e8de49bbf67ca7f786f39c98c70caa3875c57de041e016321dec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Female</topic><topic>Radiation Dosage</topic><topic>Radiation Injuries, Experimental - pathology</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Surgical Flaps</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Kant Y</creatorcontrib><creatorcontrib>Patterson, James W</creatorcontrib><creatorcontrib>Simmons, Joshua</creatorcontrib><creatorcontrib>Long, Millie D</creatorcontrib><creatorcontrib>Schultz, Raymond O</creatorcontrib><creatorcontrib>Amiss, L R</creatorcontrib><creatorcontrib>Molloy, Janelle A</creatorcontrib><creatorcontrib>Kelly, Maria D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Plastic and reconstructive surgery (1963)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Kant Y</au><au>Patterson, James W</au><au>Simmons, Joshua</au><au>Long, Millie D</au><au>Schultz, Raymond O</au><au>Amiss, L R</au><au>Molloy, Janelle A</au><au>Kelly, Maria D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of External Beam Irradiation on the TRAM Flap: An Experimental Model</atitle><jtitle>Plastic and reconstructive surgery (1963)</jtitle><addtitle>Plast Reconstr Surg</addtitle><date>2001-04-15</date><risdate>2001</risdate><volume>107</volume><issue>5</issue><spage>1190</spage><epage>1197</epage><pages>1190-1197</pages><issn>0032-1052</issn><eissn>1529-4242</eissn><abstract>The rat model of the transverse rectus abdominis musculocutaneous (TRAM) flap was used in the present study to determine the effects of external beam radiation on myocutaneous flap histology and pathophysiology. A total of 57 adult Sprague-Dawley rats underwent a TRAM procedure. A pilot study with 17 animals was first performed to determine proper radiation dosages, and the remaining 40 rats were then used in the definitive study. In half of the definitive study group, the flaps were subjected to fractionated doses of external beam radiation, whereas the other half served as controls. Six weeks after the last radiation dose, all animals were killed and the flaps were harvested for mechanical assessment and histopathologic evaluation. All TRAM flaps survived in both groups. The irradiated and nonirradiated flaps were minimally distinguishable in viscoelastic properties, as well as by histopathologic examination. Growth of the flap in the irradiated animals was significantly diminished (48 percent average surface area increase in irradiated flaps, versus 92 percent increase in nonirradiated flaps, p < 0.05). These findings suggest that the myocutaneous flap is relatively resistant to some of the known adverse affects of radiation on living tissues. (Plast. Reconstr. Surg. 1071190, 2001.)</abstract><cop>United States</cop><pub>American Society of Plastic Surgeons</pub><pmid>11373560</pmid><doi>10.1097/00006534-200104150-00014</doi><tpages>8</tpages></addata></record> |
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source | MEDLINE; Journals@Ovid Complete |
subjects | Animals Female Radiation Dosage Radiation Injuries, Experimental - pathology Random Allocation Rats Rats, Sprague-Dawley Surgical Flaps |
title | Effects of External Beam Irradiation on the TRAM Flap: An Experimental Model |
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