Effects of dapiprazole on the reversal of pharmacologically induced mydriasis
The ability of a new alpha-adrenergic antagonist, dapiprazole, to reverse mydriasis produced by phenylephrine 2.5% or 10%, tropicamide 0.5%, and the combination of phenylephrine 2.5% and tropicamide 0.5% was investigated. A double masked crossover design was used to study both efficacy of mydriatic...
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| Veröffentlicht in: | Optometry and vision science 1990-09, Vol.67 (9), p.705-709 |
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| container_title | Optometry and vision science |
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| creator | NYMAN, N KEATES, E. U |
| description | The ability of a new alpha-adrenergic antagonist, dapiprazole, to reverse mydriasis produced by phenylephrine 2.5% or 10%, tropicamide 0.5%, and the combination of phenylephrine 2.5% and tropicamide 0.5% was investigated. A double masked crossover design was used to study both efficacy of mydriatic reversal and time course. The safety of administration was evaluated as well. Subjects were optometry students and their spouses. The results demonstrate that dapiprazole is safe and effective for reversing mydriasis produced by both concentrations of phenylephrine, and partially effective in reversing mydriasis in eyes treated with tropicamide 0.5%, alone, or in combination with 2.5% phenylephrine. |
| doi_str_mv | 10.1097/00006324-199009000-00009 |
| format | Article |
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U</creatorcontrib><title>Effects of dapiprazole on the reversal of pharmacologically induced mydriasis</title><title>Optometry and vision science</title><addtitle>Optom Vis Sci</addtitle><description>The ability of a new alpha-adrenergic antagonist, dapiprazole, to reverse mydriasis produced by phenylephrine 2.5% or 10%, tropicamide 0.5%, and the combination of phenylephrine 2.5% and tropicamide 0.5% was investigated. A double masked crossover design was used to study both efficacy of mydriatic reversal and time course. The safety of administration was evaluated as well. Subjects were optometry students and their spouses. 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Drug treatments</subject><subject>Phenylephrine - antagonists & inhibitors</subject><subject>Piperazines</subject><subject>Pupil - drug effects</subject><subject>Time Factors</subject><subject>Triazoles - pharmacology</subject><subject>Triazoles - toxicity</subject><subject>Tropicamide - antagonists & inhibitors</subject><subject>Visual Acuity - drug effects</subject><issn>1040-5488</issn><issn>1538-9235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFUE1LAzEQDaLUWv0JQg5eo0kmn0cp9QMqXvS8pNnErux2l6QV6q83tbUOAzPMmze8eQhhRm8ZtfqOllDABWHWUlqSkt3InqAxk2CI5SBPS08FJVIYc44ucv6klGmQaoRGzGrDtRyjl1mMwa8z7iOu3dAMyX33bcD9Cq-XAafwFVJ27Q4eli51zvdt_9F417Zb3KzqjQ817rZ1alxu8iU6i67N4epQJ-j9YfY2fSLz18fn6f2ceAC7JtorwZ0JkUYvnSqqrBWKC2AAgjmuQwwAbAGqYJJbpY0CHSGqqBfSS5ggs7_rU59zCrEaUtO5tK0YrXYGVX8GVUeDfke2UK_31GGz6EL9T9w7UvCbA-5y-TImt_JNPq5JwYAXnT8IOWzf</recordid><startdate>19900901</startdate><enddate>19900901</enddate><creator>NYMAN, N</creator><creator>KEATES, E. 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Drug treatments</topic><topic>Phenylephrine - antagonists & inhibitors</topic><topic>Piperazines</topic><topic>Pupil - drug effects</topic><topic>Time Factors</topic><topic>Triazoles - pharmacology</topic><topic>Triazoles - toxicity</topic><topic>Tropicamide - antagonists & inhibitors</topic><topic>Visual Acuity - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NYMAN, N</creatorcontrib><creatorcontrib>KEATES, E. U</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Optometry and vision science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NYMAN, N</au><au>KEATES, E. U</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of dapiprazole on the reversal of pharmacologically induced mydriasis</atitle><jtitle>Optometry and vision science</jtitle><addtitle>Optom Vis Sci</addtitle><date>1990-09-01</date><risdate>1990</risdate><volume>67</volume><issue>9</issue><spage>705</spage><epage>709</epage><pages>705-709</pages><issn>1040-5488</issn><eissn>1538-9235</eissn><coden>OVSCET</coden><abstract>The ability of a new alpha-adrenergic antagonist, dapiprazole, to reverse mydriasis produced by phenylephrine 2.5% or 10%, tropicamide 0.5%, and the combination of phenylephrine 2.5% and tropicamide 0.5% was investigated. A double masked crossover design was used to study both efficacy of mydriatic reversal and time course. The safety of administration was evaluated as well. Subjects were optometry students and their spouses. The results demonstrate that dapiprazole is safe and effective for reversing mydriasis produced by both concentrations of phenylephrine, and partially effective in reversing mydriasis in eyes treated with tropicamide 0.5%, alone, or in combination with 2.5% phenylephrine.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>1978275</pmid><doi>10.1097/00006324-199009000-00009</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 1040-5488 |
| ispartof | Optometry and vision science, 1990-09, Vol.67 (9), p.705-709 |
| issn | 1040-5488 1538-9235 |
| language | eng |
| recordid | cdi_crossref_primary_10_1097_00006324_199009000_00009 |
| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Accommodation, Ocular - drug effects Adrenergic alpha-Antagonists - pharmacology Adult Biological and medical sciences Blood Pressure - drug effects Double-Blind Method Female Humans Intraocular Pressure - drug effects Male Medical sciences Mydriatics - antagonists & inhibitors Neuropharmacology Pharmacology. Drug treatments Phenylephrine - antagonists & inhibitors Piperazines Pupil - drug effects Time Factors Triazoles - pharmacology Triazoles - toxicity Tropicamide - antagonists & inhibitors Visual Acuity - drug effects |
| title | Effects of dapiprazole on the reversal of pharmacologically induced mydriasis |
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