Antepartum and Intrapartum Events in Women Exposed In Utero to Diethylstilbestrol
Using a retrospective cohort design, we analyzed the effects of intrauterine diethylstilbestrol (DES) exposure on various antepartum and intrapartum events. Gravidas exposed to DES had a higher likelihood of being delivered abdominally, undergoing manual removal of the placenta, and hemorrhaging in...
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| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 1990-11, Vol.76 (5), p.828-832 |
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| container_issue | 5 |
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| container_title | Obstetrics and gynecology (New York. 1953) |
| container_volume | 76 |
| creator | THORP, JOHN M. FOWLER, WESLEY C. DONEHOO, RALPH SAWICKI, CAROLE BOWES, WATSON A. |
| description | Using a retrospective cohort design, we analyzed the effects of intrauterine diethylstilbestrol (DES) exposure on various antepartum and intrapartum events. Gravidas exposed to DES had a higher likelihood of being delivered abdominally, undergoing manual removal of the placenta, and hemorrhaging in the postpartum period. The increased risk for these events remained after controlling for age, race, and parity. We also constructed labor curves in DES-exposed women by plotting cervical dilation against time. The curves were similar for nulliparous DES-exposed women and nulliparous controls, but DES-exposed parous women experienced prolonged labors. These findings suggest that, in addition to the well-known adverse effects of intrauterine DES exposure, the interaction between the uterus and placenta is altered in some DES-exposed patients. (Obstet Gynecol 76:828, 1990) |
| doi_str_mv | 10.1097/00006250-199011000-00021 |
| format | Article |
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Gravidas exposed to DES had a higher likelihood of being delivered abdominally, undergoing manual removal of the placenta, and hemorrhaging in the postpartum period. The increased risk for these events remained after controlling for age, race, and parity. We also constructed labor curves in DES-exposed women by plotting cervical dilation against time. The curves were similar for nulliparous DES-exposed women and nulliparous controls, but DES-exposed parous women experienced prolonged labors. These findings suggest that, in addition to the well-known adverse effects of intrauterine DES exposure, the interaction between the uterus and placenta is altered in some DES-exposed patients. 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Drug treatments ; Postpartum Hemorrhage - chemically induced ; Postpartum Hemorrhage - epidemiology ; Pregnancy ; Pregnancy Complications - chemically induced ; Pregnancy Complications - epidemiology ; Prenatal Exposure Delayed Effects ; Retrospective Studies ; Risk Factors ; Time Factors</subject><ispartof>Obstetrics and gynecology (New York. 1953), 1990-11, Vol.76 (5), p.828-832</ispartof><rights>1990 The American College of Obstetricians and Gynecologists</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3001-5bd6b7c6aa4aa7be8c6b1260e76d476361b603f46345a24d05bda03072b3b64c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19455819$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2216234$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>THORP, JOHN M.</creatorcontrib><creatorcontrib>FOWLER, WESLEY C.</creatorcontrib><creatorcontrib>DONEHOO, RALPH</creatorcontrib><creatorcontrib>SAWICKI, CAROLE</creatorcontrib><creatorcontrib>BOWES, WATSON A.</creatorcontrib><title>Antepartum and Intrapartum Events in Women Exposed In Utero to Diethylstilbestrol</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>Using a retrospective cohort design, we analyzed the effects of intrauterine diethylstilbestrol (DES) exposure on various antepartum and intrapartum events. Gravidas exposed to DES had a higher likelihood of being delivered abdominally, undergoing manual removal of the placenta, and hemorrhaging in the postpartum period. The increased risk for these events remained after controlling for age, race, and parity. We also constructed labor curves in DES-exposed women by plotting cervical dilation against time. The curves were similar for nulliparous DES-exposed women and nulliparous controls, but DES-exposed parous women experienced prolonged labors. These findings suggest that, in addition to the well-known adverse effects of intrauterine DES exposure, the interaction between the uterus and placenta is altered in some DES-exposed patients. (Obstet Gynecol 76:828, 1990)</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cohort Studies</subject><subject>Delivery, Obstetric</subject><subject>Diethylstilbestrol - adverse effects</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Obstetric Labor Complications - chemically induced</subject><subject>Obstetric Labor Complications - epidemiology</subject><subject>Parity</subject><subject>Pharmacology. Drug treatments</subject><subject>Postpartum Hemorrhage - chemically induced</subject><subject>Postpartum Hemorrhage - epidemiology</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - chemically induced</subject><subject>Pregnancy Complications - epidemiology</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Time Factors</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtLAzEUhYMotVZ_gpCNy9G8JplZllq1IIhg0V1IZjJ0NPMgSa3996Z2rCsDIdx7zzlcvgAAMbrGKBc3KB5OUpTgPEcYxyqJl-AjMMaZoAmh9O0YjGMrT0TG2Ck48_49SjDP6QiMCMGcUDYGz9M2mF65sG6gaku4aINTQz3_NG3wsG7ha9eYFs6_-s6bnQYug3EdDB28rU1Yba0PtdXGB9fZc3BSKevNxfBOwPJu_jJ7SB6f7hez6WNS0LhGkuqSa1FwpZhSQpus4BoTjozgJROccqw5ohXjlKWKsBJFg0IUCaKp5qygE5DtcwvXee9MJXtXN8ptJUZyB0n-QpIHSPIHUrRe7q39WjemPBgHKnF-NcyVL5StnGqL2v_l5yxNM5xHHdvrNp2NQPyHXW-MkyujbFjJ__6IfgNug36G</recordid><startdate>199011</startdate><enddate>199011</enddate><creator>THORP, JOHN M.</creator><creator>FOWLER, WESLEY C.</creator><creator>DONEHOO, RALPH</creator><creator>SAWICKI, CAROLE</creator><creator>BOWES, WATSON A.</creator><general>The American College of Obstetricians and Gynecologists</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199011</creationdate><title>Antepartum and Intrapartum Events in Women Exposed In Utero to Diethylstilbestrol</title><author>THORP, JOHN M. ; FOWLER, WESLEY C. ; DONEHOO, RALPH ; SAWICKI, CAROLE ; BOWES, WATSON A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3001-5bd6b7c6aa4aa7be8c6b1260e76d476361b603f46345a24d05bda03072b3b64c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cohort Studies</topic><topic>Delivery, Obstetric</topic><topic>Diethylstilbestrol - adverse effects</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Female</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Miscellaneous (drug allergy, mutagens, teratogens...)</topic><topic>Obstetric Labor Complications - chemically induced</topic><topic>Obstetric Labor Complications - epidemiology</topic><topic>Parity</topic><topic>Pharmacology. Drug treatments</topic><topic>Postpartum Hemorrhage - chemically induced</topic><topic>Postpartum Hemorrhage - epidemiology</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - chemically induced</topic><topic>Pregnancy Complications - epidemiology</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>THORP, JOHN M.</creatorcontrib><creatorcontrib>FOWLER, WESLEY C.</creatorcontrib><creatorcontrib>DONEHOO, RALPH</creatorcontrib><creatorcontrib>SAWICKI, CAROLE</creatorcontrib><creatorcontrib>BOWES, WATSON A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>THORP, JOHN M.</au><au>FOWLER, WESLEY C.</au><au>DONEHOO, RALPH</au><au>SAWICKI, CAROLE</au><au>BOWES, WATSON A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antepartum and Intrapartum Events in Women Exposed In Utero to Diethylstilbestrol</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>1990-11</date><risdate>1990</risdate><volume>76</volume><issue>5</issue><spage>828</spage><epage>832</epage><pages>828-832</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><coden>OBGNAS</coden><abstract>Using a retrospective cohort design, we analyzed the effects of intrauterine diethylstilbestrol (DES) exposure on various antepartum and intrapartum events. Gravidas exposed to DES had a higher likelihood of being delivered abdominally, undergoing manual removal of the placenta, and hemorrhaging in the postpartum period. The increased risk for these events remained after controlling for age, race, and parity. We also constructed labor curves in DES-exposed women by plotting cervical dilation against time. The curves were similar for nulliparous DES-exposed women and nulliparous controls, but DES-exposed parous women experienced prolonged labors. These findings suggest that, in addition to the well-known adverse effects of intrauterine DES exposure, the interaction between the uterus and placenta is altered in some DES-exposed patients. (Obstet Gynecol 76:828, 1990)</abstract><cop>New York, NY</cop><pub>The American College of Obstetricians and Gynecologists</pub><pmid>2216234</pmid><doi>10.1097/00006250-199011000-00021</doi><tpages>5</tpages></addata></record> |
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| ispartof | Obstetrics and gynecology (New York. 1953), 1990-11, Vol.76 (5), p.828-832 |
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| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Adult Biological and medical sciences Cohort Studies Delivery, Obstetric Diethylstilbestrol - adverse effects Drug toxicity and drugs side effects treatment Female Humans Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Obstetric Labor Complications - chemically induced Obstetric Labor Complications - epidemiology Parity Pharmacology. Drug treatments Postpartum Hemorrhage - chemically induced Postpartum Hemorrhage - epidemiology Pregnancy Pregnancy Complications - chemically induced Pregnancy Complications - epidemiology Prenatal Exposure Delayed Effects Retrospective Studies Risk Factors Time Factors |
| title | Antepartum and Intrapartum Events in Women Exposed In Utero to Diethylstilbestrol |
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