Different AT1 Receptor Subtypes at Pre- and Postjunctional Sites: AT1A versus AT1B Receptors
Angiotensin (AT) II is known to enhance responses to electrical field stimulation (EFS) via AT1 receptors located on sympathetic nerve terminals. Differences in potency exist between AT1 receptor antagonists regarding the inhibition of the prejunctional and postjunctional AT1 receptors. It is hypoth...
Gespeichert in:
| Veröffentlicht in: | Journal of cardiovascular pharmacology 2004-01, Vol.43 (1), p.14-20 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 20 |
|---|---|
| container_issue | 1 |
| container_start_page | 14 |
| container_title | Journal of cardiovascular pharmacology |
| container_volume | 43 |
| creator | Nap, Alexander Balt, Jippe C Mathy, Marie-Jeanne Pfaffendorf, Martin van Zwieten, Pieter A |
| description | Angiotensin (AT) II is known to enhance responses to electrical field stimulation (EFS) via AT1 receptors located on sympathetic nerve terminals. Differences in potency exist between AT1 receptor antagonists regarding the inhibition of the prejunctional and postjunctional AT1 receptors. It is hypothesized that prejunctional AT1 receptors might belong to the AT1B receptor subtype. Accordingly, the authors investigated whether AT1B receptor inhibition by high concentrations of PD123319 could suppress ATII-augmented noradrenergic transmission (prejunctional) in the rabbit thoracic aorta by means of a noradrenaline spillover model. Additionally, the influence of PD123319 on ATII-enhanced constrictor responses to electrical field stimulation was investigated in the isolated rabbit mesenteric artery. Furthermore, the authors investigated whether PD123319 could influence the constrictor responses (postjunctional) to ATII in both preparations. In the thoracic aorta, ATII (10 n M) caused a significant enhancement of EFS-evoked [H]-noradrenaline release by a factor of 2.0 ± 0.1. This reinforcement could be inhibited by PD123319 (0.1, 1, and 10 μM). The constrictor response to ATII was unaffected by PD123319. In the mesenteric artery, ATII (0.5 n M) caused a significant enhancement of constrictor responses to EFS by factors of 2.9 ± 0.3, 2.3 ± 0.3, and 1.6 ± 0.1 at 1, 2, and 4 Hz, respectively. This enhancement could be attenuated by PD123319 (1 and 10 μM). The constrictor response to ATII was unaffected by PD123319. It is concluded that the prejunctional AT1 receptors belong to the AT1B subtype whereas postjunctional AT1 receptors do not. |
| doi_str_mv | 10.1097/00005344-200401000-00003 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1097_00005344_200401000_00003</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>14668562</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3193-f5a37a87a185840f315372eb340caf14386a93786c91ce8228068f7dc0352d8a3</originalsourceid><addsrcrecordid>eNp1UctOwzAQtBCIlsIvIP-AwfY6jsOtvJEqUdFyQ4pcx1FT0iSyHar-PQkt5cRe9qGZkWYWIczoFaNJfE27ikAIwikVlHUb6U9whIYsAiCCcjhGQ8okJVwIOUBn3q8oZSKK5SkaMCGliiQfoo_7Is-ts1XA4znDb9bYJtQOz9pF2DbWYx3w1FmCdZXhae3Dqq1MKOpKl3hWBOtvet4Yf1nnW9_PtwcRf45Ocl16e7HvI_T--DC_eyaT16eXu_GEGGAJkDzSEGsVa6YiJWgOnYeY2wUIanTOBCipE4iVNAkzVnGuqFR5nBkKEc-UhhFSO13jau-dzdPGFWvttimjaR9Y-htYegjs5wQd9XJHbdrF2mZ_xH1CHUDsAJu6DJ3Jz7LdWJcurS7DMv3vEfANy8FzKA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Different AT1 Receptor Subtypes at Pre- and Postjunctional Sites: AT1A versus AT1B Receptors</title><source>MEDLINE</source><source>Journals@Ovid LWW Legacy Archive</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Journals@Ovid Complete</source><creator>Nap, Alexander ; Balt, Jippe C ; Mathy, Marie-Jeanne ; Pfaffendorf, Martin ; van Zwieten, Pieter A</creator><creatorcontrib>Nap, Alexander ; Balt, Jippe C ; Mathy, Marie-Jeanne ; Pfaffendorf, Martin ; van Zwieten, Pieter A</creatorcontrib><description>Angiotensin (AT) II is known to enhance responses to electrical field stimulation (EFS) via AT1 receptors located on sympathetic nerve terminals. Differences in potency exist between AT1 receptor antagonists regarding the inhibition of the prejunctional and postjunctional AT1 receptors. It is hypothesized that prejunctional AT1 receptors might belong to the AT1B receptor subtype. Accordingly, the authors investigated whether AT1B receptor inhibition by high concentrations of PD123319 could suppress ATII-augmented noradrenergic transmission (prejunctional) in the rabbit thoracic aorta by means of a noradrenaline spillover model. Additionally, the influence of PD123319 on ATII-enhanced constrictor responses to electrical field stimulation was investigated in the isolated rabbit mesenteric artery. Furthermore, the authors investigated whether PD123319 could influence the constrictor responses (postjunctional) to ATII in both preparations. In the thoracic aorta, ATII (10 n M) caused a significant enhancement of EFS-evoked [H]-noradrenaline release by a factor of 2.0 ± 0.1. This reinforcement could be inhibited by PD123319 (0.1, 1, and 10 μM). The constrictor response to ATII was unaffected by PD123319. In the mesenteric artery, ATII (0.5 n M) caused a significant enhancement of constrictor responses to EFS by factors of 2.9 ± 0.3, 2.3 ± 0.3, and 1.6 ± 0.1 at 1, 2, and 4 Hz, respectively. This enhancement could be attenuated by PD123319 (1 and 10 μM). The constrictor response to ATII was unaffected by PD123319. It is concluded that the prejunctional AT1 receptors belong to the AT1B subtype whereas postjunctional AT1 receptors do not.</description><identifier>ISSN: 0160-2446</identifier><identifier>EISSN: 1533-4023</identifier><identifier>DOI: 10.1097/00005344-200401000-00003</identifier><identifier>PMID: 14668562</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins, Inc</publisher><subject>Angiotensin II - pharmacology ; Animals ; Drug Interactions ; Electric Stimulation ; Imidazoles - pharmacology ; Male ; Muscle, Smooth, Vascular ; Pyridines - pharmacology ; Rabbits ; Receptor, Angiotensin, Type 1 - classification ; Receptor, Angiotensin, Type 1 - drug effects ; Vasoconstrictor Agents - pharmacology</subject><ispartof>Journal of cardiovascular pharmacology, 2004-01, Vol.43 (1), p.14-20</ispartof><rights>2004 Lippincott Williams & Wilkins, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3193-f5a37a87a185840f315372eb340caf14386a93786c91ce8228068f7dc0352d8a3</citedby><cites>FETCH-LOGICAL-c3193-f5a37a87a185840f315372eb340caf14386a93786c91ce8228068f7dc0352d8a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00005344-200401000-00003$$EHTML$$P50$$Gwolterskluwer$$H</linktohtml><link.rule.ids>314,776,780,4595,27901,27902,65206</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14668562$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nap, Alexander</creatorcontrib><creatorcontrib>Balt, Jippe C</creatorcontrib><creatorcontrib>Mathy, Marie-Jeanne</creatorcontrib><creatorcontrib>Pfaffendorf, Martin</creatorcontrib><creatorcontrib>van Zwieten, Pieter A</creatorcontrib><title>Different AT1 Receptor Subtypes at Pre- and Postjunctional Sites: AT1A versus AT1B Receptors</title><title>Journal of cardiovascular pharmacology</title><addtitle>J Cardiovasc Pharmacol</addtitle><description>Angiotensin (AT) II is known to enhance responses to electrical field stimulation (EFS) via AT1 receptors located on sympathetic nerve terminals. Differences in potency exist between AT1 receptor antagonists regarding the inhibition of the prejunctional and postjunctional AT1 receptors. It is hypothesized that prejunctional AT1 receptors might belong to the AT1B receptor subtype. Accordingly, the authors investigated whether AT1B receptor inhibition by high concentrations of PD123319 could suppress ATII-augmented noradrenergic transmission (prejunctional) in the rabbit thoracic aorta by means of a noradrenaline spillover model. Additionally, the influence of PD123319 on ATII-enhanced constrictor responses to electrical field stimulation was investigated in the isolated rabbit mesenteric artery. Furthermore, the authors investigated whether PD123319 could influence the constrictor responses (postjunctional) to ATII in both preparations. In the thoracic aorta, ATII (10 n M) caused a significant enhancement of EFS-evoked [H]-noradrenaline release by a factor of 2.0 ± 0.1. This reinforcement could be inhibited by PD123319 (0.1, 1, and 10 μM). The constrictor response to ATII was unaffected by PD123319. In the mesenteric artery, ATII (0.5 n M) caused a significant enhancement of constrictor responses to EFS by factors of 2.9 ± 0.3, 2.3 ± 0.3, and 1.6 ± 0.1 at 1, 2, and 4 Hz, respectively. This enhancement could be attenuated by PD123319 (1 and 10 μM). The constrictor response to ATII was unaffected by PD123319. It is concluded that the prejunctional AT1 receptors belong to the AT1B subtype whereas postjunctional AT1 receptors do not.</description><subject>Angiotensin II - pharmacology</subject><subject>Animals</subject><subject>Drug Interactions</subject><subject>Electric Stimulation</subject><subject>Imidazoles - pharmacology</subject><subject>Male</subject><subject>Muscle, Smooth, Vascular</subject><subject>Pyridines - pharmacology</subject><subject>Rabbits</subject><subject>Receptor, Angiotensin, Type 1 - classification</subject><subject>Receptor, Angiotensin, Type 1 - drug effects</subject><subject>Vasoconstrictor Agents - pharmacology</subject><issn>0160-2446</issn><issn>1533-4023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UctOwzAQtBCIlsIvIP-AwfY6jsOtvJEqUdFyQ4pcx1FT0iSyHar-PQkt5cRe9qGZkWYWIczoFaNJfE27ikAIwikVlHUb6U9whIYsAiCCcjhGQ8okJVwIOUBn3q8oZSKK5SkaMCGliiQfoo_7Is-ts1XA4znDb9bYJtQOz9pF2DbWYx3w1FmCdZXhae3Dqq1MKOpKl3hWBOtvet4Yf1nnW9_PtwcRf45Ocl16e7HvI_T--DC_eyaT16eXu_GEGGAJkDzSEGsVa6YiJWgOnYeY2wUIanTOBCipE4iVNAkzVnGuqFR5nBkKEc-UhhFSO13jau-dzdPGFWvttimjaR9Y-htYegjs5wQd9XJHbdrF2mZ_xH1CHUDsAJu6DJ3Jz7LdWJcurS7DMv3vEfANy8FzKA</recordid><startdate>200401</startdate><enddate>200401</enddate><creator>Nap, Alexander</creator><creator>Balt, Jippe C</creator><creator>Mathy, Marie-Jeanne</creator><creator>Pfaffendorf, Martin</creator><creator>van Zwieten, Pieter A</creator><general>Lippincott Williams & Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200401</creationdate><title>Different AT1 Receptor Subtypes at Pre- and Postjunctional Sites: AT1A versus AT1B Receptors</title><author>Nap, Alexander ; Balt, Jippe C ; Mathy, Marie-Jeanne ; Pfaffendorf, Martin ; van Zwieten, Pieter A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3193-f5a37a87a185840f315372eb340caf14386a93786c91ce8228068f7dc0352d8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Angiotensin II - pharmacology</topic><topic>Animals</topic><topic>Drug Interactions</topic><topic>Electric Stimulation</topic><topic>Imidazoles - pharmacology</topic><topic>Male</topic><topic>Muscle, Smooth, Vascular</topic><topic>Pyridines - pharmacology</topic><topic>Rabbits</topic><topic>Receptor, Angiotensin, Type 1 - classification</topic><topic>Receptor, Angiotensin, Type 1 - drug effects</topic><topic>Vasoconstrictor Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nap, Alexander</creatorcontrib><creatorcontrib>Balt, Jippe C</creatorcontrib><creatorcontrib>Mathy, Marie-Jeanne</creatorcontrib><creatorcontrib>Pfaffendorf, Martin</creatorcontrib><creatorcontrib>van Zwieten, Pieter A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of cardiovascular pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nap, Alexander</au><au>Balt, Jippe C</au><au>Mathy, Marie-Jeanne</au><au>Pfaffendorf, Martin</au><au>van Zwieten, Pieter A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Different AT1 Receptor Subtypes at Pre- and Postjunctional Sites: AT1A versus AT1B Receptors</atitle><jtitle>Journal of cardiovascular pharmacology</jtitle><addtitle>J Cardiovasc Pharmacol</addtitle><date>2004-01</date><risdate>2004</risdate><volume>43</volume><issue>1</issue><spage>14</spage><epage>20</epage><pages>14-20</pages><issn>0160-2446</issn><eissn>1533-4023</eissn><abstract>Angiotensin (AT) II is known to enhance responses to electrical field stimulation (EFS) via AT1 receptors located on sympathetic nerve terminals. Differences in potency exist between AT1 receptor antagonists regarding the inhibition of the prejunctional and postjunctional AT1 receptors. It is hypothesized that prejunctional AT1 receptors might belong to the AT1B receptor subtype. Accordingly, the authors investigated whether AT1B receptor inhibition by high concentrations of PD123319 could suppress ATII-augmented noradrenergic transmission (prejunctional) in the rabbit thoracic aorta by means of a noradrenaline spillover model. Additionally, the influence of PD123319 on ATII-enhanced constrictor responses to electrical field stimulation was investigated in the isolated rabbit mesenteric artery. Furthermore, the authors investigated whether PD123319 could influence the constrictor responses (postjunctional) to ATII in both preparations. In the thoracic aorta, ATII (10 n M) caused a significant enhancement of EFS-evoked [H]-noradrenaline release by a factor of 2.0 ± 0.1. This reinforcement could be inhibited by PD123319 (0.1, 1, and 10 μM). The constrictor response to ATII was unaffected by PD123319. In the mesenteric artery, ATII (0.5 n M) caused a significant enhancement of constrictor responses to EFS by factors of 2.9 ± 0.3, 2.3 ± 0.3, and 1.6 ± 0.1 at 1, 2, and 4 Hz, respectively. This enhancement could be attenuated by PD123319 (1 and 10 μM). The constrictor response to ATII was unaffected by PD123319. It is concluded that the prejunctional AT1 receptors belong to the AT1B subtype whereas postjunctional AT1 receptors do not.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>14668562</pmid><doi>10.1097/00005344-200401000-00003</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0160-2446 |
| ispartof | Journal of cardiovascular pharmacology, 2004-01, Vol.43 (1), p.14-20 |
| issn | 0160-2446 1533-4023 |
| language | eng |
| recordid | cdi_crossref_primary_10_1097_00005344_200401000_00003 |
| source | MEDLINE; Journals@Ovid LWW Legacy Archive; EZB-FREE-00999 freely available EZB journals; Journals@Ovid Complete |
| subjects | Angiotensin II - pharmacology Animals Drug Interactions Electric Stimulation Imidazoles - pharmacology Male Muscle, Smooth, Vascular Pyridines - pharmacology Rabbits Receptor, Angiotensin, Type 1 - classification Receptor, Angiotensin, Type 1 - drug effects Vasoconstrictor Agents - pharmacology |
| title | Different AT1 Receptor Subtypes at Pre- and Postjunctional Sites: AT1A versus AT1B Receptors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T20%3A58%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Different%20AT1%20Receptor%20Subtypes%20at%20Pre-%20and%20Postjunctional%20Sites:%20AT1A%20versus%20AT1B%20Receptors&rft.jtitle=Journal%20of%20cardiovascular%20pharmacology&rft.au=Nap,%20Alexander&rft.date=2004-01&rft.volume=43&rft.issue=1&rft.spage=14&rft.epage=20&rft.pages=14-20&rft.issn=0160-2446&rft.eissn=1533-4023&rft_id=info:doi/10.1097/00005344-200401000-00003&rft_dat=%3Cpubmed_cross%3E14668562%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/14668562&rfr_iscdi=true |