Combined Sodium and Calcium Channel Blockade in Prevention of Lethal Arrhythmias

Anti-arrhythmic compounds with multiple actions reduce arrhythmic death risk in post–myocardial infarction (MI) patients. Sudden death prevention, however, may rely more on implantable defibrillators than anti-arrhythmic drugs due to ineffective pharmacologic intervention. Widespread use of implanta...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 2003-05, Vol.41 (5), p.665-670
Hauptverfasser:	Adamson, Philip B, Vanoli, Emilio, Shibano, Toshiro, Foreman, Robert D, Schwartz, Peter J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Antagonists - pharmacology Animals Anti-Arrhythmia Agents - pharmacology Anti-Arrhythmia Agents - therapeutic use Biological and medical sciences Calcium Channel Blockers - pharmacology Calcium Channel Blockers - therapeutic use Death, Sudden, Cardiac - etiology Death, Sudden, Cardiac - prevention & control Depression, Chemical Dogs Drug Synergism Drug Therapy, Combination Heart Rate - drug effects Isoproterenol - pharmacology Medical sciences Myocardial Infarction - complications Physical Conditioning, Animal Propranolol - pharmacology Sodium Channel Blockers - pharmacology Sodium Channel Blockers - therapeutic use Thiazoles - pharmacology Ventricular Fibrillation - etiology Ventricular Fibrillation - mortality Ventricular Fibrillation - prevention & control
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