Functional Role of β2-Adrenoceptors in the Transplanted Human Heart
In the transplanted human heart, β-adrenoceptor subtypes change with time after transplantationβ1-adrenoceptors tend to decline, whereas β2-adrenoceptors are upregulated. The aim of this study was to determine whether, in the transplanted human heart, stimulation of β2-adrenoceptors can induce heart...
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| Veröffentlicht in: | Journal of cardiovascular pharmacology 1997-12, Vol.30 (6), p.811-816 |
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| container_title | Journal of cardiovascular pharmacology |
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| creator | Hakim, Kavous Fischer, Martin Günnicker, Michael Poenicke, Klaus Zerkowski, Hans-Reinhard Brodde, Otto-Erich |
| description | In the transplanted human heart, β-adrenoceptor subtypes change with time after transplantationβ1-adrenoceptors tend to decline, whereas β2-adrenoceptors are upregulated. The aim of this study was to determine whether, in the transplanted human heart, stimulation of β2-adrenoceptors can induce heart-rate increases. For this purpose, we assessed in eight heart-transplant recipients (mean posttransplant time932 days) the effects of infusion of graded doses of isoprenaline (3.5-35 ng/kg/min) 120 min after pretreatment with the β1-adrenoceptor antagonist bisoprolol (10 mg p.o.; β1-adrenoceptor occupancy ∼80%; β2-adrenoceptor occupancy 35 ng/kg/min (p < 0.01). We conclude that in the transplanted human heart, β2-adrenoceptor stimulation does evoke increases in heart rate. The enhanced response to isoprenaline in the transplanted sinus node could be caused by the upregulated β2-adrenoceptors or by the fact that during isoprenaline infusion, vagal activity increases, thus blunting the response in the native (innervated) but not in the transplanted (denervated) sinus node. |
| doi_str_mv | 10.1097/00005344-199712000-00017 |
| format | Article |
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The aim of this study was to determine whether, in the transplanted human heart, stimulation of β2-adrenoceptors can induce heart-rate increases. For this purpose, we assessed in eight heart-transplant recipients (mean posttransplant time932 days) the effects of infusion of graded doses of isoprenaline (3.5-35 ng/kg/min) 120 min after pretreatment with the β1-adrenoceptor antagonist bisoprolol (10 mg p.o.; β1-adrenoceptor occupancy ∼80%; β2-adrenoceptor occupancy <5%) on heart rate in the recipient's native (innervated) and transplanted (denervated) sinus nodes. Isoprenaline, acting under these conditions predominantly at β2-adrenoceptors, increased heart rate both in the recipient's transplanted and native sinus nodes in a dose-dependent manner; at each dose, increases were significantly higher in the transplanted than in the native sinus node. ED20 values (dose to increase heart rate by 20 beats/min) in the transplanted sinus node were 22.2 ± 1.8 ng/kg/min, and in the native, >35 ng/kg/min (p < 0.01). We conclude that in the transplanted human heart, β2-adrenoceptor stimulation does evoke increases in heart rate. The enhanced response to isoprenaline in the transplanted sinus node could be caused by the upregulated β2-adrenoceptors or by the fact that during isoprenaline infusion, vagal activity increases, thus blunting the response in the native (innervated) but not in the transplanted (denervated) sinus node.</description><identifier>ISSN: 0160-2446</identifier><identifier>EISSN: 1533-4023</identifier><identifier>DOI: 10.1097/00005344-199712000-00017</identifier><identifier>CODEN: JCPCDT</identifier><language>eng</language><publisher>Philadelphia, PA: Lippincott-Raven Publishers</publisher><subject>Biological and medical sciences ; Cell receptors ; Cell structures and functions ; Fundamental and applied biological sciences. Psychology ; Heart ; Molecular and cellular biology ; Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine) ; Vertebrates: cardiovascular system</subject><ispartof>Journal of cardiovascular pharmacology, 1997-12, Vol.30 (6), p.811-816</ispartof><rights>Lippincott-Raven Publishers</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2287-ff9029dce9594a06fc219fbd4c7e965e017274c148a256375d7eca08a047e2993</citedby><cites>FETCH-LOGICAL-c2287-ff9029dce9594a06fc219fbd4c7e965e017274c148a256375d7eca08a047e2993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00005344-199712000-00017$$EHTML$$P50$$Gwolterskluwer$$H</linktohtml><link.rule.ids>314,776,780,4595,27901,27902,65206</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2127053$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Hakim, Kavous</creatorcontrib><creatorcontrib>Fischer, Martin</creatorcontrib><creatorcontrib>Günnicker, Michael</creatorcontrib><creatorcontrib>Poenicke, Klaus</creatorcontrib><creatorcontrib>Zerkowski, Hans-Reinhard</creatorcontrib><creatorcontrib>Brodde, Otto-Erich</creatorcontrib><title>Functional Role of β2-Adrenoceptors in the Transplanted Human Heart</title><title>Journal of cardiovascular pharmacology</title><description>In the transplanted human heart, β-adrenoceptor subtypes change with time after transplantationβ1-adrenoceptors tend to decline, whereas β2-adrenoceptors are upregulated. The aim of this study was to determine whether, in the transplanted human heart, stimulation of β2-adrenoceptors can induce heart-rate increases. For this purpose, we assessed in eight heart-transplant recipients (mean posttransplant time932 days) the effects of infusion of graded doses of isoprenaline (3.5-35 ng/kg/min) 120 min after pretreatment with the β1-adrenoceptor antagonist bisoprolol (10 mg p.o.; β1-adrenoceptor occupancy ∼80%; β2-adrenoceptor occupancy <5%) on heart rate in the recipient's native (innervated) and transplanted (denervated) sinus nodes. Isoprenaline, acting under these conditions predominantly at β2-adrenoceptors, increased heart rate both in the recipient's transplanted and native sinus nodes in a dose-dependent manner; at each dose, increases were significantly higher in the transplanted than in the native sinus node. ED20 values (dose to increase heart rate by 20 beats/min) in the transplanted sinus node were 22.2 ± 1.8 ng/kg/min, and in the native, >35 ng/kg/min (p < 0.01). We conclude that in the transplanted human heart, β2-adrenoceptor stimulation does evoke increases in heart rate. The enhanced response to isoprenaline in the transplanted sinus node could be caused by the upregulated β2-adrenoceptors or by the fact that during isoprenaline infusion, vagal activity increases, thus blunting the response in the native (innervated) but not in the transplanted (denervated) sinus node.</description><subject>Biological and medical sciences</subject><subject>Cell receptors</subject><subject>Cell structures and functions</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart</subject><subject>Molecular and cellular biology</subject><subject>Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine)</subject><subject>Vertebrates: cardiovascular system</subject><issn>0160-2446</issn><issn>1533-4023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNp1kMFKAzEQhoMoWKvvkIPXaJLNbjbHUq0VBEHqOcTshK6myZJsKb6WD-IzGa32ZmAIA_83zHwIYUavGFXympZXV0IQppRkvHSkFJNHaMLqqiKC8uoYTShrKOFCNKfoLOfXkhC1bCboZrENduxjMB4_RQ84Ovz5wcmsSxCihWGMKeM-4HENeJVMyIM3YYQOL7cbE_ASTBrP0YkzPsPF7z9Fz4vb1XxJHh7v7uezB2I5byVxTlGuOguqVsLQxlnOlHvphJWgmhrK1lwKy0RreN1Usu4kWENbQ4UErlQ1Re1-rk0x5wROD6nfmPSuGdXfNvSfDX2woX9sFPRyjw4mW-NducT2-cBzxmUBS0zsY7voR0j5zW93kPQajB_X-j_X1RcKD24u</recordid><startdate>199712</startdate><enddate>199712</enddate><creator>Hakim, Kavous</creator><creator>Fischer, Martin</creator><creator>Günnicker, Michael</creator><creator>Poenicke, Klaus</creator><creator>Zerkowski, Hans-Reinhard</creator><creator>Brodde, Otto-Erich</creator><general>Lippincott-Raven Publishers</general><general>Lippincott</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199712</creationdate><title>Functional Role of β2-Adrenoceptors in the Transplanted Human Heart</title><author>Hakim, Kavous ; Fischer, Martin ; Günnicker, Michael ; Poenicke, Klaus ; Zerkowski, Hans-Reinhard ; Brodde, Otto-Erich</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2287-ff9029dce9594a06fc219fbd4c7e965e017274c148a256375d7eca08a047e2993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Biological and medical sciences</topic><topic>Cell receptors</topic><topic>Cell structures and functions</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart</topic><topic>Molecular and cellular biology</topic><topic>Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine)</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hakim, Kavous</creatorcontrib><creatorcontrib>Fischer, Martin</creatorcontrib><creatorcontrib>Günnicker, Michael</creatorcontrib><creatorcontrib>Poenicke, Klaus</creatorcontrib><creatorcontrib>Zerkowski, Hans-Reinhard</creatorcontrib><creatorcontrib>Brodde, Otto-Erich</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>Journal of cardiovascular pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hakim, Kavous</au><au>Fischer, Martin</au><au>Günnicker, Michael</au><au>Poenicke, Klaus</au><au>Zerkowski, Hans-Reinhard</au><au>Brodde, Otto-Erich</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional Role of β2-Adrenoceptors in the Transplanted Human Heart</atitle><jtitle>Journal of cardiovascular pharmacology</jtitle><date>1997-12</date><risdate>1997</risdate><volume>30</volume><issue>6</issue><spage>811</spage><epage>816</epage><pages>811-816</pages><issn>0160-2446</issn><eissn>1533-4023</eissn><coden>JCPCDT</coden><abstract>In the transplanted human heart, β-adrenoceptor subtypes change with time after transplantationβ1-adrenoceptors tend to decline, whereas β2-adrenoceptors are upregulated. The aim of this study was to determine whether, in the transplanted human heart, stimulation of β2-adrenoceptors can induce heart-rate increases. For this purpose, we assessed in eight heart-transplant recipients (mean posttransplant time932 days) the effects of infusion of graded doses of isoprenaline (3.5-35 ng/kg/min) 120 min after pretreatment with the β1-adrenoceptor antagonist bisoprolol (10 mg p.o.; β1-adrenoceptor occupancy ∼80%; β2-adrenoceptor occupancy <5%) on heart rate in the recipient's native (innervated) and transplanted (denervated) sinus nodes. Isoprenaline, acting under these conditions predominantly at β2-adrenoceptors, increased heart rate both in the recipient's transplanted and native sinus nodes in a dose-dependent manner; at each dose, increases were significantly higher in the transplanted than in the native sinus node. ED20 values (dose to increase heart rate by 20 beats/min) in the transplanted sinus node were 22.2 ± 1.8 ng/kg/min, and in the native, >35 ng/kg/min (p < 0.01). We conclude that in the transplanted human heart, β2-adrenoceptor stimulation does evoke increases in heart rate. The enhanced response to isoprenaline in the transplanted sinus node could be caused by the upregulated β2-adrenoceptors or by the fact that during isoprenaline infusion, vagal activity increases, thus blunting the response in the native (innervated) but not in the transplanted (denervated) sinus node.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><doi>10.1097/00005344-199712000-00017</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Journals@Ovid LWW Legacy Archive; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Biological and medical sciences Cell receptors Cell structures and functions Fundamental and applied biological sciences. Psychology Heart Molecular and cellular biology Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine) Vertebrates: cardiovascular system |
| title | Functional Role of β2-Adrenoceptors in the Transplanted Human Heart |
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