Bioactivation of Monocrotaline by P-450 3A in Rat Liver

Monocrotaline (MCT) is bioactivated in liver cytochrome P-450s to MCT pyrrole (MCTP), which primarily injures the lung endothelium to result in the development of pulmonary hypertension (PH) in rats. However, whether there is a relation between the degree of PH and the activity of liver cytochrome P...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 1997-07, Vol.30 (1), p.124-129
Hauptverfasser:	Kasahara, Yasunori, Kiyatake, Kunio, Tatsumi, Koichiro, Sugito, Kazutoshi, Kakusaka, Ikuei, Yamagata, Shin-ichi, Ohmori, Shigeru, Kitada, Mitsukazu, Kuriyama, Takayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aryl Hydrocarbon Hydroxylases Biological and medical sciences Biotransformation Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System - immunology Cytochrome P-450 Enzyme System - metabolism Female Heart - drug effects Heart Ventricles - pathology Hypertension, Pulmonary - chemically induced Hypertension, Pulmonary - metabolism Hypertension, Pulmonary - pathology Hypertension, Pulmonary - physiopathology Hypertrophy Immunoglobulin G - immunology Liver - enzymology Liver - immunology Male Medical sciences Microsomes, Liver - enzymology Microsomes, Liver - immunology Monocrotaline - analogs & derivatives Monocrotaline - metabolism Monocrotaline - toxicity Orchiectomy Organ Size Oxidoreductases, N-Demethylating - immunology Oxidoreductases, N-Demethylating - metabolism Plant poisons toxicology Rats Rats, Sprague-Dawley Sex Factors Toxicology Ventricular Pressure - drug effects
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