Nitrendipine in Patients with End-Stage Renal Disease and Hypertension
Calcium antagonists reduce the calcium uptake in vascular cells. The reduction of intracellular calcium leads to vasodilatation and lowering of the blood pressure. The cardiac output is increased, for example, by nitrendipine and related agents, so that the supply of blood to essential organs is imp...
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| Veröffentlicht in: | Journal of cardiovascular pharmacology 1988, Vol.12 Suppl 4, p.S133-S135 |
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| container_end_page | S135 |
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| container_title | Journal of cardiovascular pharmacology |
| container_volume | 12 Suppl 4 |
| creator | Bambauer, R Jutzler, G A Weber, U Walter, R Keller, H E |
| description | Calcium antagonists reduce the calcium uptake in vascular cells. The reduction of intracellular calcium leads to vasodilatation and lowering of the blood pressure. The cardiac output is increased, for example, by nitrendipine and related agents, so that the supply of blood to essential organs is improved. Despite the blood pressure decrease, the plasma renin activity increases only slightly and the plasma aldosterone concentration not at all after administration of nitrendipine. The effects of nitrendipine were examined in a study carried out over a period of 6 months on 10 patients suffering from renal hypertension and end-stage renal disease requiring compulsory dialysis. In all patients, adequate blood pressure control was achieved with, in some cases, low doses of nitrendipine combined with other antihypertensive medication. Nitrendipine was very well tolerated, and no side effects were observed. |
| doi_str_mv | 10.1097/00005344-198806124-00029 |
| format | Article |
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The reduction of intracellular calcium leads to vasodilatation and lowering of the blood pressure. The cardiac output is increased, for example, by nitrendipine and related agents, so that the supply of blood to essential organs is improved. Despite the blood pressure decrease, the plasma renin activity increases only slightly and the plasma aldosterone concentration not at all after administration of nitrendipine. The effects of nitrendipine were examined in a study carried out over a period of 6 months on 10 patients suffering from renal hypertension and end-stage renal disease requiring compulsory dialysis. In all patients, adequate blood pressure control was achieved with, in some cases, low doses of nitrendipine combined with other antihypertensive medication. 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The reduction of intracellular calcium leads to vasodilatation and lowering of the blood pressure. The cardiac output is increased, for example, by nitrendipine and related agents, so that the supply of blood to essential organs is improved. Despite the blood pressure decrease, the plasma renin activity increases only slightly and the plasma aldosterone concentration not at all after administration of nitrendipine. The effects of nitrendipine were examined in a study carried out over a period of 6 months on 10 patients suffering from renal hypertension and end-stage renal disease requiring compulsory dialysis. In all patients, adequate blood pressure control was achieved with, in some cases, low doses of nitrendipine combined with other antihypertensive medication. Nitrendipine was very well tolerated, and no side effects were observed.</description><subject>Adult</subject><subject>Aged</subject><subject>Blood Pressure - drug effects</subject><subject>Female</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Hypertension, Renal - drug therapy</subject><subject>Kidney Failure, Chronic - complications</subject><subject>Kidney Failure, Chronic - physiopathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nitrendipine - adverse effects</subject><subject>Nitrendipine - therapeutic use</subject><issn>0160-2446</issn><issn>1533-4023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kNtKAzEQhoMotVYfQcgLRJPNYbOXUqsVioqH65DdndjoNi1JSunbu9raO-fmh_n5huFDCDN6xWhVXtN-JBeCsEprqlghSL8pqiM0ZJJzImjBj9GQMkVJIYQ6RWcpfVLKhCzVAA0KobSWaojuHn2OEFq_8gGwD_jZZg8hJ7zxeY4noSWv2X4AfoFgO3zrE9gE2IYWT7criBlC8stwjk6c7RJc7HOE3u8mb-MpmT3dP4xvZqThklZEN0pJJTkrdd0UzkrLqC1dLSW3sv-Oa8GkbSW0umbclS3VstCOuUY4WSnHR0jv7jZxmVIEZ1bRL2zcGkbNjxnzZ8YczJhfMz16uUNX63oB7QHcq-h7ses3yy5DTF_degPRzMF2eW7-E86_AaZybTA</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>Bambauer, R</creator><creator>Jutzler, G A</creator><creator>Weber, U</creator><creator>Walter, R</creator><creator>Keller, H E</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1988</creationdate><title>Nitrendipine in Patients with End-Stage Renal Disease and Hypertension</title><author>Bambauer, R ; Jutzler, G A ; Weber, U ; Walter, R ; Keller, H E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3509-8c665653178bc2fa5a10a7fb553a500138415ad5ed8b13f7d08528f1fc4f596f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Blood Pressure - drug effects</topic><topic>Female</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>Hypertension, Renal - drug therapy</topic><topic>Kidney Failure, Chronic - complications</topic><topic>Kidney Failure, Chronic - physiopathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nitrendipine - adverse effects</topic><topic>Nitrendipine - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bambauer, R</creatorcontrib><creatorcontrib>Jutzler, G A</creatorcontrib><creatorcontrib>Weber, U</creatorcontrib><creatorcontrib>Walter, R</creatorcontrib><creatorcontrib>Keller, H E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of cardiovascular pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bambauer, R</au><au>Jutzler, G A</au><au>Weber, U</au><au>Walter, R</au><au>Keller, H E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nitrendipine in Patients with End-Stage Renal Disease and Hypertension</atitle><jtitle>Journal of cardiovascular pharmacology</jtitle><addtitle>J Cardiovasc Pharmacol</addtitle><date>1988</date><risdate>1988</risdate><volume>12 Suppl 4</volume><spage>S133</spage><epage>S135</epage><pages>S133-S135</pages><issn>0160-2446</issn><eissn>1533-4023</eissn><abstract>Calcium antagonists reduce the calcium uptake in vascular cells. The reduction of intracellular calcium leads to vasodilatation and lowering of the blood pressure. The cardiac output is increased, for example, by nitrendipine and related agents, so that the supply of blood to essential organs is improved. Despite the blood pressure decrease, the plasma renin activity increases only slightly and the plasma aldosterone concentration not at all after administration of nitrendipine. The effects of nitrendipine were examined in a study carried out over a period of 6 months on 10 patients suffering from renal hypertension and end-stage renal disease requiring compulsory dialysis. In all patients, adequate blood pressure control was achieved with, in some cases, low doses of nitrendipine combined with other antihypertensive medication. Nitrendipine was very well tolerated, and no side effects were observed.</abstract><cop>United States</cop><pub>Lippincott-Raven Publishers</pub><pmid>2468856</pmid><doi>10.1097/00005344-198806124-00029</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0160-2446 |
| ispartof | Journal of cardiovascular pharmacology, 1988, Vol.12 Suppl 4, p.S133-S135 |
| issn | 0160-2446 1533-4023 |
| language | eng |
| recordid | cdi_crossref_primary_10_1097_00005344_198806124_00029 |
| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Blood Pressure - drug effects Female Heart Rate - drug effects Humans Hypertension, Renal - drug therapy Kidney Failure, Chronic - complications Kidney Failure, Chronic - physiopathology Male Middle Aged Nitrendipine - adverse effects Nitrendipine - therapeutic use |
| title | Nitrendipine in Patients with End-Stage Renal Disease and Hypertension |
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