Allosteric Modulation of [3H]Nitrendipine Binding to Cardiac and Cerebral Cortex Membranes by Amiodarone

The possible interaction between the antianginal and antiarrhythmic drug amiodarone and the slow calcium channel was investigated by competition binding experiments in guinea-pig cerebral cortex and rat heart membranes using [H]nitrendipine as radioligand. Amiodarone displaced specifically bound [H]...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 1986-09, Vol.8 (5), p.1051-1057
Hauptverfasser:	Nokin, P, Clinet, M, Swillens, S, Delisée, C, Meysmans, L, Chatelain, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation - drug effects Allosteric Site - drug effects Amiodarone - pharmacology Animals Binding, Competitive - drug effects Biological and medical sciences Cardiovascular system Cerebral Cortex - drug effects Cerebral Cortex - metabolism Drug Interactions Guinea Pigs Heart - drug effects In Vitro Techniques Medical sciences Miscellaneous Myocardium - metabolism Nitrendipine - metabolism Pharmacology. Drug treatments Rats
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