EFFECTS OF SINGLE DOSE SUPERVOLTAGE WHOLE BRAIN RADIATION IN MACACA MULATTA
Three groups of four Macaca mulatta were exposed respectively to a single dose of 1000, 1500, and 2000 rads of 20 MeV whole brain radiation with one animal from each group and a control scheduled for sacrifice at 6, 12, 18, and 24 months. With 1000 rads there were no abnormalities. The characteristi...
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Veröffentlicht in: | J. Neuropathol. Exp. Neurol.; (United States) 1977-11, Vol.36 (6), p.916-940 |
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description | Three groups of four Macaca mulatta were exposed respectively to a single dose of 1000, 1500, and 2000 rads of 20 MeV whole brain radiation with one animal from each group and a control scheduled for sacrifice at 6, 12, 18, and 24 months. With 1000 rads there were no abnormalities. The characteristic lesions in the animals exposed to 1500 and 2000 rads were small foci of delayed radiation necrosis that in the acute phase were relatively large due to marked local accumulation of edema fluid and at later stages were decreased in volume and showed early mineralization. Correspondingly the monkeys frequently showed papilledema, evidently from brain swelling, as the initial clinical finding, and upon histological examination at later stages, brain atrophy and ventricular dilatation. After exposure to 1500 rads the necrotic process was primarily in the white matter of the cerebral hemisphere and progressed from a small numberof lesions in this location at 6 months to confluent necrosis at 12 months. At 18 and 24 months, although there was no evidence of further necrosis, there was evidence of increasing gliosis and at 24 months the occurrence of three independent glioblastomas. With exposure to 2000 rads there was a profuse wide scatter of focal necrotic lesions with a predilection for the basis pontis and a clinical deficit inconsistent with survival past 6 months. Accumulation of minute mineral deposits and atherosclerotic plaques were also noted in these monkeys and appeared to be related to both dose and survival time. |
doi_str_mv | 10.1097/00005072-197711000-00004 |
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With 1000 rads there were no abnormalities. The characteristic lesions in the animals exposed to 1500 and 2000 rads were small foci of delayed radiation necrosis that in the acute phase were relatively large due to marked local accumulation of edema fluid and at later stages were decreased in volume and showed early mineralization. Correspondingly the monkeys frequently showed papilledema, evidently from brain swelling, as the initial clinical finding, and upon histological examination at later stages, brain atrophy and ventricular dilatation. After exposure to 1500 rads the necrotic process was primarily in the white matter of the cerebral hemisphere and progressed from a small numberof lesions in this location at 6 months to confluent necrosis at 12 months. At 18 and 24 months, although there was no evidence of further necrosis, there was evidence of increasing gliosis and at 24 months the occurrence of three independent glioblastomas. With exposure to 2000 rads there was a profuse wide scatter of focal necrotic lesions with a predilection for the basis pontis and a clinical deficit inconsistent with survival past 6 months. Accumulation of minute mineral deposits and atherosclerotic plaques were also noted in these monkeys and appeared to be related to both dose and survival time.</description><identifier>ISSN: 0022-3069</identifier><identifier>EISSN: 1554-6578</identifier><identifier>DOI: 10.1097/00005072-197711000-00004</identifier><identifier>PMID: 411893</identifier><language>eng</language><publisher>England: American Association of Neuropathologists, Inc</publisher><subject>560152 - Radiation Effects on Animals- Animals ; ANIMALS ; BIOLOGICAL EFFECTS ; BIOLOGICAL RADIATION EFFECTS ; BODY ; BRAIN ; Brain - radiation effects ; Brain Edema - pathology ; Brain Neoplasms - pathology ; Brain Stem - radiation effects ; Calculi - pathology ; CENTRAL NERVOUS SYSTEM ; Cerebral Cortex - pathology ; Cerebral Cortex - radiation effects ; DISEASES ; Dose-Response Relationship, Radiation ; DOSE-RESPONSE RELATIONSHIPS ; Electroencephalography ; ELECTROMAGNETIC RADIATION ; Haplorhini ; Hypothalamus - radiation effects ; IONIZING RADIATIONS ; Macaca mulatta ; MACACUS ; MAMMALS ; MONKEYS ; NECROSIS ; Neoplasms, Radiation-Induced - pathology ; NERVOUS SYSTEM ; Optic Nerve - radiation effects ; ORGANS ; PATHOLOGICAL CHANGES ; PRIMATES ; RADIATION EFFECTS ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RADIATIONS ; RADIOINDUCTION ; VERTEBRATES ; X RADIATION</subject><ispartof>J. Neuropathol. Exp. Neurol.; (United States), 1977-11, Vol.36 (6), p.916-940</ispartof><rights>1977 American Association of Neuropathologists, Inc</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3814-ec1412a4c1eece37b9f49fcdb22196f7bff7dbb57367401d9ca3bdb6fd95a9d73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,882,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/411893$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5111538$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>KEMPER, THOMAS L</creatorcontrib><creatorcontrib>CAVENESS, WILLIAM F</creatorcontrib><creatorcontrib>OʼNEILL, RAYMOND</creatorcontrib><title>EFFECTS OF SINGLE DOSE SUPERVOLTAGE WHOLE BRAIN RADIATION IN MACACA MULATTA</title><title>J. Neuropathol. Exp. Neurol.; (United States)</title><addtitle>J Neuropathol Exp Neurol</addtitle><description>Three groups of four Macaca mulatta were exposed respectively to a single dose of 1000, 1500, and 2000 rads of 20 MeV whole brain radiation with one animal from each group and a control scheduled for sacrifice at 6, 12, 18, and 24 months. With 1000 rads there were no abnormalities. The characteristic lesions in the animals exposed to 1500 and 2000 rads were small foci of delayed radiation necrosis that in the acute phase were relatively large due to marked local accumulation of edema fluid and at later stages were decreased in volume and showed early mineralization. Correspondingly the monkeys frequently showed papilledema, evidently from brain swelling, as the initial clinical finding, and upon histological examination at later stages, brain atrophy and ventricular dilatation. After exposure to 1500 rads the necrotic process was primarily in the white matter of the cerebral hemisphere and progressed from a small numberof lesions in this location at 6 months to confluent necrosis at 12 months. At 18 and 24 months, although there was no evidence of further necrosis, there was evidence of increasing gliosis and at 24 months the occurrence of three independent glioblastomas. With exposure to 2000 rads there was a profuse wide scatter of focal necrotic lesions with a predilection for the basis pontis and a clinical deficit inconsistent with survival past 6 months. Accumulation of minute mineral deposits and atherosclerotic plaques were also noted in these monkeys and appeared to be related to both dose and survival time.</description><subject>560152 - Radiation Effects on Animals- Animals</subject><subject>ANIMALS</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BIOLOGICAL RADIATION EFFECTS</subject><subject>BODY</subject><subject>BRAIN</subject><subject>Brain - radiation effects</subject><subject>Brain Edema - pathology</subject><subject>Brain Neoplasms - pathology</subject><subject>Brain Stem - radiation effects</subject><subject>Calculi - pathology</subject><subject>CENTRAL NERVOUS SYSTEM</subject><subject>Cerebral Cortex - pathology</subject><subject>Cerebral Cortex - radiation effects</subject><subject>DISEASES</subject><subject>Dose-Response Relationship, Radiation</subject><subject>DOSE-RESPONSE RELATIONSHIPS</subject><subject>Electroencephalography</subject><subject>ELECTROMAGNETIC RADIATION</subject><subject>Haplorhini</subject><subject>Hypothalamus - radiation effects</subject><subject>IONIZING RADIATIONS</subject><subject>Macaca mulatta</subject><subject>MACACUS</subject><subject>MAMMALS</subject><subject>MONKEYS</subject><subject>NECROSIS</subject><subject>Neoplasms, Radiation-Induced - pathology</subject><subject>NERVOUS SYSTEM</subject><subject>Optic Nerve - radiation effects</subject><subject>ORGANS</subject><subject>PATHOLOGICAL CHANGES</subject><subject>PRIMATES</subject><subject>RADIATION EFFECTS</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RADIATIONS</subject><subject>RADIOINDUCTION</subject><subject>VERTEBRATES</subject><subject>X RADIATION</subject><issn>0022-3069</issn><issn>1554-6578</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UU1Pg0AQ3Ri_avUfeNh4R3fYhWWP2NKWSIspVI8bWJa0Sj8CNI3_3q1ob84cJu_Ne3N4gxAG8ghE8CdiyiHctkBwDmCQdaTYGeqB4zDLdbh3jnqE2LZFiSuu0U3TfBiFIIJdoUsG4AnaQy_BaBQM0gTHI5yEs3EU4GGcBDhZvAbztzhK_XGA3yex4Z_nfjjDc38Y-mkYz7ABU39gGk8XkZ-m_i26KLOq0Xe_s48WoyAdTKwoHocDP7IU9YBZWgEDO2MKtFaa8lyUTJSqyG0bhFvyvCx5kecOpy5nBAqhMpoXuVsWwslEwWkfPXR3t027ko1atVot1Xaz0aqVDgA41DMirxOpets0tS7lrl6ts_pLApHHCOVfhPIU4Q_FjPW-s-72-VoXJ2OXmVmzbn3YVq2um89qf9C1XOqsapfyv8fQb9addDM</recordid><startdate>197711</startdate><enddate>197711</enddate><creator>KEMPER, THOMAS L</creator><creator>CAVENESS, WILLIAM F</creator><creator>OʼNEILL, RAYMOND</creator><general>American Association of Neuropathologists, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>197711</creationdate><title>EFFECTS OF SINGLE DOSE SUPERVOLTAGE WHOLE BRAIN RADIATION IN MACACA MULATTA</title><author>KEMPER, THOMAS L ; CAVENESS, WILLIAM F ; OʼNEILL, RAYMOND</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3814-ec1412a4c1eece37b9f49fcdb22196f7bff7dbb57367401d9ca3bdb6fd95a9d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>560152 - Radiation Effects on Animals- Animals</topic><topic>ANIMALS</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BIOLOGICAL RADIATION EFFECTS</topic><topic>BODY</topic><topic>BRAIN</topic><topic>Brain - radiation effects</topic><topic>Brain Edema - pathology</topic><topic>Brain Neoplasms - pathology</topic><topic>Brain Stem - radiation effects</topic><topic>Calculi - pathology</topic><topic>CENTRAL NERVOUS SYSTEM</topic><topic>Cerebral Cortex - pathology</topic><topic>Cerebral Cortex - radiation effects</topic><topic>DISEASES</topic><topic>Dose-Response Relationship, Radiation</topic><topic>DOSE-RESPONSE RELATIONSHIPS</topic><topic>Electroencephalography</topic><topic>ELECTROMAGNETIC RADIATION</topic><topic>Haplorhini</topic><topic>Hypothalamus - radiation effects</topic><topic>IONIZING RADIATIONS</topic><topic>Macaca mulatta</topic><topic>MACACUS</topic><topic>MAMMALS</topic><topic>MONKEYS</topic><topic>NECROSIS</topic><topic>Neoplasms, Radiation-Induced - pathology</topic><topic>NERVOUS SYSTEM</topic><topic>Optic Nerve - radiation effects</topic><topic>ORGANS</topic><topic>PATHOLOGICAL CHANGES</topic><topic>PRIMATES</topic><topic>RADIATION EFFECTS</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RADIATIONS</topic><topic>RADIOINDUCTION</topic><topic>VERTEBRATES</topic><topic>X RADIATION</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KEMPER, THOMAS L</creatorcontrib><creatorcontrib>CAVENESS, WILLIAM F</creatorcontrib><creatorcontrib>OʼNEILL, RAYMOND</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>J. Neuropathol. Exp. Neurol.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KEMPER, THOMAS L</au><au>CAVENESS, WILLIAM F</au><au>OʼNEILL, RAYMOND</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EFFECTS OF SINGLE DOSE SUPERVOLTAGE WHOLE BRAIN RADIATION IN MACACA MULATTA</atitle><jtitle>J. Neuropathol. Exp. Neurol.; (United States)</jtitle><addtitle>J Neuropathol Exp Neurol</addtitle><date>1977-11</date><risdate>1977</risdate><volume>36</volume><issue>6</issue><spage>916</spage><epage>940</epage><pages>916-940</pages><issn>0022-3069</issn><eissn>1554-6578</eissn><abstract>Three groups of four Macaca mulatta were exposed respectively to a single dose of 1000, 1500, and 2000 rads of 20 MeV whole brain radiation with one animal from each group and a control scheduled for sacrifice at 6, 12, 18, and 24 months. With 1000 rads there were no abnormalities. The characteristic lesions in the animals exposed to 1500 and 2000 rads were small foci of delayed radiation necrosis that in the acute phase were relatively large due to marked local accumulation of edema fluid and at later stages were decreased in volume and showed early mineralization. Correspondingly the monkeys frequently showed papilledema, evidently from brain swelling, as the initial clinical finding, and upon histological examination at later stages, brain atrophy and ventricular dilatation. After exposure to 1500 rads the necrotic process was primarily in the white matter of the cerebral hemisphere and progressed from a small numberof lesions in this location at 6 months to confluent necrosis at 12 months. At 18 and 24 months, although there was no evidence of further necrosis, there was evidence of increasing gliosis and at 24 months the occurrence of three independent glioblastomas. With exposure to 2000 rads there was a profuse wide scatter of focal necrotic lesions with a predilection for the basis pontis and a clinical deficit inconsistent with survival past 6 months. Accumulation of minute mineral deposits and atherosclerotic plaques were also noted in these monkeys and appeared to be related to both dose and survival time.</abstract><cop>England</cop><pub>American Association of Neuropathologists, Inc</pub><pmid>411893</pmid><doi>10.1097/00005072-197711000-00004</doi><tpages>25</tpages></addata></record> |
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issn | 0022-3069 1554-6578 |
language | eng |
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source | Oxford University Press Journals Digital Archive legacy; MEDLINE; Journals@Ovid Ovid Autoload |
subjects | 560152 - Radiation Effects on Animals- Animals ANIMALS BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS BODY BRAIN Brain - radiation effects Brain Edema - pathology Brain Neoplasms - pathology Brain Stem - radiation effects Calculi - pathology CENTRAL NERVOUS SYSTEM Cerebral Cortex - pathology Cerebral Cortex - radiation effects DISEASES Dose-Response Relationship, Radiation DOSE-RESPONSE RELATIONSHIPS Electroencephalography ELECTROMAGNETIC RADIATION Haplorhini Hypothalamus - radiation effects IONIZING RADIATIONS Macaca mulatta MACACUS MAMMALS MONKEYS NECROSIS Neoplasms, Radiation-Induced - pathology NERVOUS SYSTEM Optic Nerve - radiation effects ORGANS PATHOLOGICAL CHANGES PRIMATES RADIATION EFFECTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIATIONS RADIOINDUCTION VERTEBRATES X RADIATION |
title | EFFECTS OF SINGLE DOSE SUPERVOLTAGE WHOLE BRAIN RADIATION IN MACACA MULATTA |
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