EFFECTS OF SINGLE DOSE SUPERVOLTAGE WHOLE BRAIN RADIATION IN MACACA MULATTA

Three groups of four Macaca mulatta were exposed respectively to a single dose of 1000, 1500, and 2000 rads of 20 MeV whole brain radiation with one animal from each group and a control scheduled for sacrifice at 6, 12, 18, and 24 months. With 1000 rads there were no abnormalities. The characteristi...

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Veröffentlicht in:J. Neuropathol. Exp. Neurol.; (United States) 1977-11, Vol.36 (6), p.916-940
Hauptverfasser: KEMPER, THOMAS L, CAVENESS, WILLIAM F, OʼNEILL, RAYMOND
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CAVENESS, WILLIAM F
OʼNEILL, RAYMOND
description Three groups of four Macaca mulatta were exposed respectively to a single dose of 1000, 1500, and 2000 rads of 20 MeV whole brain radiation with one animal from each group and a control scheduled for sacrifice at 6, 12, 18, and 24 months. With 1000 rads there were no abnormalities. The characteristic lesions in the animals exposed to 1500 and 2000 rads were small foci of delayed radiation necrosis that in the acute phase were relatively large due to marked local accumulation of edema fluid and at later stages were decreased in volume and showed early mineralization. Correspondingly the monkeys frequently showed papilledema, evidently from brain swelling, as the initial clinical finding, and upon histological examination at later stages, brain atrophy and ventricular dilatation. After exposure to 1500 rads the necrotic process was primarily in the white matter of the cerebral hemisphere and progressed from a small numberof lesions in this location at 6 months to confluent necrosis at 12 months. At 18 and 24 months, although there was no evidence of further necrosis, there was evidence of increasing gliosis and at 24 months the occurrence of three independent glioblastomas. With exposure to 2000 rads there was a profuse wide scatter of focal necrotic lesions with a predilection for the basis pontis and a clinical deficit inconsistent with survival past 6 months. Accumulation of minute mineral deposits and atherosclerotic plaques were also noted in these monkeys and appeared to be related to both dose and survival time.
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With exposure to 2000 rads there was a profuse wide scatter of focal necrotic lesions with a predilection for the basis pontis and a clinical deficit inconsistent with survival past 6 months. 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Neuropathol. Exp. Neurol.; (United States)</title><addtitle>J Neuropathol Exp Neurol</addtitle><description>Three groups of four Macaca mulatta were exposed respectively to a single dose of 1000, 1500, and 2000 rads of 20 MeV whole brain radiation with one animal from each group and a control scheduled for sacrifice at 6, 12, 18, and 24 months. With 1000 rads there were no abnormalities. The characteristic lesions in the animals exposed to 1500 and 2000 rads were small foci of delayed radiation necrosis that in the acute phase were relatively large due to marked local accumulation of edema fluid and at later stages were decreased in volume and showed early mineralization. Correspondingly the monkeys frequently showed papilledema, evidently from brain swelling, as the initial clinical finding, and upon histological examination at later stages, brain atrophy and ventricular dilatation. After exposure to 1500 rads the necrotic process was primarily in the white matter of the cerebral hemisphere and progressed from a small numberof lesions in this location at 6 months to confluent necrosis at 12 months. At 18 and 24 months, although there was no evidence of further necrosis, there was evidence of increasing gliosis and at 24 months the occurrence of three independent glioblastomas. With exposure to 2000 rads there was a profuse wide scatter of focal necrotic lesions with a predilection for the basis pontis and a clinical deficit inconsistent with survival past 6 months. Accumulation of minute mineral deposits and atherosclerotic plaques were also noted in these monkeys and appeared to be related to both dose and survival time.</description><subject>560152 - Radiation Effects on Animals- Animals</subject><subject>ANIMALS</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BIOLOGICAL RADIATION EFFECTS</subject><subject>BODY</subject><subject>BRAIN</subject><subject>Brain - radiation effects</subject><subject>Brain Edema - pathology</subject><subject>Brain Neoplasms - pathology</subject><subject>Brain Stem - radiation effects</subject><subject>Calculi - pathology</subject><subject>CENTRAL NERVOUS SYSTEM</subject><subject>Cerebral Cortex - pathology</subject><subject>Cerebral Cortex - radiation effects</subject><subject>DISEASES</subject><subject>Dose-Response Relationship, Radiation</subject><subject>DOSE-RESPONSE RELATIONSHIPS</subject><subject>Electroencephalography</subject><subject>ELECTROMAGNETIC RADIATION</subject><subject>Haplorhini</subject><subject>Hypothalamus - radiation effects</subject><subject>IONIZING RADIATIONS</subject><subject>Macaca mulatta</subject><subject>MACACUS</subject><subject>MAMMALS</subject><subject>MONKEYS</subject><subject>NECROSIS</subject><subject>Neoplasms, Radiation-Induced - pathology</subject><subject>NERVOUS SYSTEM</subject><subject>Optic Nerve - radiation effects</subject><subject>ORGANS</subject><subject>PATHOLOGICAL CHANGES</subject><subject>PRIMATES</subject><subject>RADIATION EFFECTS</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. 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POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RADIATIONS</topic><topic>RADIOINDUCTION</topic><topic>VERTEBRATES</topic><topic>X RADIATION</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KEMPER, THOMAS L</creatorcontrib><creatorcontrib>CAVENESS, WILLIAM F</creatorcontrib><creatorcontrib>OʼNEILL, RAYMOND</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>J. Neuropathol. Exp. 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The characteristic lesions in the animals exposed to 1500 and 2000 rads were small foci of delayed radiation necrosis that in the acute phase were relatively large due to marked local accumulation of edema fluid and at later stages were decreased in volume and showed early mineralization. Correspondingly the monkeys frequently showed papilledema, evidently from brain swelling, as the initial clinical finding, and upon histological examination at later stages, brain atrophy and ventricular dilatation. After exposure to 1500 rads the necrotic process was primarily in the white matter of the cerebral hemisphere and progressed from a small numberof lesions in this location at 6 months to confluent necrosis at 12 months. At 18 and 24 months, although there was no evidence of further necrosis, there was evidence of increasing gliosis and at 24 months the occurrence of three independent glioblastomas. With exposure to 2000 rads there was a profuse wide scatter of focal necrotic lesions with a predilection for the basis pontis and a clinical deficit inconsistent with survival past 6 months. Accumulation of minute mineral deposits and atherosclerotic plaques were also noted in these monkeys and appeared to be related to both dose and survival time.</abstract><cop>England</cop><pub>American Association of Neuropathologists, Inc</pub><pmid>411893</pmid><doi>10.1097/00005072-197711000-00004</doi><tpages>25</tpages></addata></record>
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identifier ISSN: 0022-3069
ispartof J. Neuropathol. Exp. Neurol.; (United States), 1977-11, Vol.36 (6), p.916-940
issn 0022-3069
1554-6578
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source Oxford University Press Journals Digital Archive legacy; MEDLINE; Journals@Ovid Ovid Autoload
subjects 560152 - Radiation Effects on Animals- Animals
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
Brain - radiation effects
Brain Edema - pathology
Brain Neoplasms - pathology
Brain Stem - radiation effects
Calculi - pathology
CENTRAL NERVOUS SYSTEM
Cerebral Cortex - pathology
Cerebral Cortex - radiation effects
DISEASES
Dose-Response Relationship, Radiation
DOSE-RESPONSE RELATIONSHIPS
Electroencephalography
ELECTROMAGNETIC RADIATION
Haplorhini
Hypothalamus - radiation effects
IONIZING RADIATIONS
Macaca mulatta
MACACUS
MAMMALS
MONKEYS
NECROSIS
Neoplasms, Radiation-Induced - pathology
NERVOUS SYSTEM
Optic Nerve - radiation effects
ORGANS
PATHOLOGICAL CHANGES
PRIMATES
RADIATION EFFECTS
RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT
RADIATIONS
RADIOINDUCTION
VERTEBRATES
X RADIATION
title EFFECTS OF SINGLE DOSE SUPERVOLTAGE WHOLE BRAIN RADIATION IN MACACA MULATTA
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