Human Psychopharmacology of Hoasca, A Plant Hallucinogen Used in Ritual Context in Brazil
A multinational, collaborative, biomedical investigation of the effects of hoasca (ayahuasca), a potent concoction of plant hallucinogens, was conducted in the Brazilian Amazon during the summer of 1993. This report describes the psychological assessment of 15 long-term members of a syncretic church...
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| Veröffentlicht in: | The journal of nervous and mental disease 1996-02, Vol.184 (2), p.86-94 |
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| container_title | The journal of nervous and mental disease |
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| creator | GROB, CHARLES S McKENNA, DENNIS J CALLAWAY, JAMES C BRITO, GLACUS S NEVES, EDISON S OBERLAENDER, GUILHERME SAIDE, OSWALDO L LABIGALINI, ELIZEU TACLA, CRISTIANE MIRANDA, CLAUDIO T STRASSMAN, RICK J BOONE, KYLE B |
| description | A multinational, collaborative, biomedical investigation of the effects of hoasca (ayahuasca), a potent concoction of plant hallucinogens, was conducted in the Brazilian Amazon during the summer of 1993. This report describes the psychological assessment of 15 long-term members of a syncretic church that utilizes hoasca as a legal, psychoactive sacrament as well as 15 matched controls with no prior history of hoasca ingestion. Measures administered to both groups included structured psychiatric diagnostic interviews, personality testing, and neuropsychological evaluation. Phenomenological assessment of the altered state experience as well as semistructured and open-ended life story interviews were conducted with the long-term use hoasca group, but not the hoasca-naive control group. Salient findings included the remission of psychopathology following the initiation of hoasca use along with no evidence of personality or cognitive deterioration. Overall assessment revealed high functional status. Implications of this unusual phenomenon and need for further investigation are discussed. |
| doi_str_mv | 10.1097/00005053-199602000-00004 |
| format | Article |
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This report describes the psychological assessment of 15 long-term members of a syncretic church that utilizes hoasca as a legal, psychoactive sacrament as well as 15 matched controls with no prior history of hoasca ingestion. Measures administered to both groups included structured psychiatric diagnostic interviews, personality testing, and neuropsychological evaluation. Phenomenological assessment of the altered state experience as well as semistructured and open-ended life story interviews were conducted with the long-term use hoasca group, but not the hoasca-naive control group. Salient findings included the remission of psychopathology following the initiation of hoasca use along with no evidence of personality or cognitive deterioration. Overall assessment revealed high functional status. Implications of this unusual phenomenon and need for further investigation are discussed.</description><identifier>ISSN: 0022-3018</identifier><identifier>EISSN: 1539-736X</identifier><identifier>DOI: 10.1097/00005053-199602000-00004</identifier><identifier>PMID: 8596116</identifier><language>eng</language><publisher>United States: Williams & Wilkins</publisher><subject>Adult ; Brazil - epidemiology ; Cognition - drug effects ; Hallucinogens - pharmacology ; Harmine - pharmacology ; Humans ; Magic ; Male ; Medicine, Traditional ; Mental Disorders - diagnosis ; Mental Disorders - epidemiology ; Middle Aged ; Neuropsychological Tests ; Personality - drug effects ; Plants, Medicinal ; Psychiatric Status Rating Scales ; Religion and Medicine ; Substance-Related Disorders - diagnosis ; Substance-Related Disorders - psychology ; Tea ; Verbal Learning - drug effects</subject><ispartof>The journal of nervous and mental disease, 1996-02, Vol.184 (2), p.86-94</ispartof><rights>Williams & Wilkins 1996. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3554-67232f12232e50a4cd084a1cf7ea82772725da6a41b62b890a91ef2991d7804a3</citedby><cites>FETCH-LOGICAL-c3554-67232f12232e50a4cd084a1cf7ea82772725da6a41b62b890a91ef2991d7804a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8596116$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GROB, CHARLES S</creatorcontrib><creatorcontrib>McKENNA, DENNIS J</creatorcontrib><creatorcontrib>CALLAWAY, JAMES C</creatorcontrib><creatorcontrib>BRITO, GLACUS S</creatorcontrib><creatorcontrib>NEVES, EDISON S</creatorcontrib><creatorcontrib>OBERLAENDER, GUILHERME</creatorcontrib><creatorcontrib>SAIDE, OSWALDO L</creatorcontrib><creatorcontrib>LABIGALINI, ELIZEU</creatorcontrib><creatorcontrib>TACLA, CRISTIANE</creatorcontrib><creatorcontrib>MIRANDA, CLAUDIO T</creatorcontrib><creatorcontrib>STRASSMAN, RICK J</creatorcontrib><creatorcontrib>BOONE, KYLE B</creatorcontrib><title>Human Psychopharmacology of Hoasca, A Plant Hallucinogen Used in Ritual Context in Brazil</title><title>The journal of nervous and mental disease</title><addtitle>J Nerv Ment Dis</addtitle><description>A multinational, collaborative, biomedical investigation of the effects of hoasca (ayahuasca), a potent concoction of plant hallucinogens, was conducted in the Brazilian Amazon during the summer of 1993. This report describes the psychological assessment of 15 long-term members of a syncretic church that utilizes hoasca as a legal, psychoactive sacrament as well as 15 matched controls with no prior history of hoasca ingestion. Measures administered to both groups included structured psychiatric diagnostic interviews, personality testing, and neuropsychological evaluation. Phenomenological assessment of the altered state experience as well as semistructured and open-ended life story interviews were conducted with the long-term use hoasca group, but not the hoasca-naive control group. Salient findings included the remission of psychopathology following the initiation of hoasca use along with no evidence of personality or cognitive deterioration. Overall assessment revealed high functional status. Implications of this unusual phenomenon and need for further investigation are discussed.</description><subject>Adult</subject><subject>Brazil - epidemiology</subject><subject>Cognition - drug effects</subject><subject>Hallucinogens - pharmacology</subject><subject>Harmine - pharmacology</subject><subject>Humans</subject><subject>Magic</subject><subject>Male</subject><subject>Medicine, Traditional</subject><subject>Mental Disorders - diagnosis</subject><subject>Mental Disorders - epidemiology</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests</subject><subject>Personality - drug effects</subject><subject>Plants, Medicinal</subject><subject>Psychiatric Status Rating Scales</subject><subject>Religion and Medicine</subject><subject>Substance-Related Disorders - diagnosis</subject><subject>Substance-Related Disorders - psychology</subject><subject>Tea</subject><subject>Verbal Learning - drug effects</subject><issn>0022-3018</issn><issn>1539-736X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kd1Kw0AQhRdRaq0-grAPYHR_s9nLWtQIBYtY0KswTTZNdJstuwm1Pr2p1d45FzPMOZy5-AYhTMk1JVrdkL4kkTyiWseE9Vu0k8QRGlLJdaR4_HqMhoQwFnFCk1N0FsI7IVRxQQZokEgdUxoP0VvaraDBs7DNK7euwK8gd9Ytt9iVOHUQcrjCYzyz0LQ4BWu7vG7c0jR4HkyB6wY_120HFk9c05rPdqfceviq7Tk6KcEGc_E7R2h-f_cySaPp08PjZDyNci6liGLFOCsp67uRBERekEQAzUtlIGFKMcVkATEIuojZItEENDUl05oWKiEC-Agl-7u5dyF4U2ZrX6_AbzNKsh2s7A9WdoD1I4k-ermPrrvFyhSH4C-d3hd7f-Nsa3z4sN3G-KwyYNsq--8H_BsEmnMj</recordid><startdate>199602</startdate><enddate>199602</enddate><creator>GROB, CHARLES S</creator><creator>McKENNA, DENNIS J</creator><creator>CALLAWAY, JAMES C</creator><creator>BRITO, GLACUS S</creator><creator>NEVES, EDISON S</creator><creator>OBERLAENDER, GUILHERME</creator><creator>SAIDE, OSWALDO L</creator><creator>LABIGALINI, ELIZEU</creator><creator>TACLA, CRISTIANE</creator><creator>MIRANDA, CLAUDIO T</creator><creator>STRASSMAN, RICK J</creator><creator>BOONE, KYLE B</creator><general>Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199602</creationdate><title>Human Psychopharmacology of Hoasca, A Plant Hallucinogen Used in Ritual Context in Brazil</title><author>GROB, CHARLES S ; McKENNA, DENNIS J ; CALLAWAY, JAMES C ; BRITO, GLACUS S ; NEVES, EDISON S ; OBERLAENDER, GUILHERME ; SAIDE, OSWALDO L ; LABIGALINI, ELIZEU ; TACLA, CRISTIANE ; MIRANDA, CLAUDIO T ; STRASSMAN, RICK J ; BOONE, KYLE B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3554-67232f12232e50a4cd084a1cf7ea82772725da6a41b62b890a91ef2991d7804a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Brazil - epidemiology</topic><topic>Cognition - drug effects</topic><topic>Hallucinogens - pharmacology</topic><topic>Harmine - pharmacology</topic><topic>Humans</topic><topic>Magic</topic><topic>Male</topic><topic>Medicine, Traditional</topic><topic>Mental Disorders - diagnosis</topic><topic>Mental Disorders - epidemiology</topic><topic>Middle Aged</topic><topic>Neuropsychological Tests</topic><topic>Personality - drug effects</topic><topic>Plants, Medicinal</topic><topic>Psychiatric Status Rating Scales</topic><topic>Religion and Medicine</topic><topic>Substance-Related Disorders - diagnosis</topic><topic>Substance-Related Disorders - psychology</topic><topic>Tea</topic><topic>Verbal Learning - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GROB, CHARLES S</creatorcontrib><creatorcontrib>McKENNA, DENNIS J</creatorcontrib><creatorcontrib>CALLAWAY, JAMES C</creatorcontrib><creatorcontrib>BRITO, GLACUS S</creatorcontrib><creatorcontrib>NEVES, EDISON S</creatorcontrib><creatorcontrib>OBERLAENDER, GUILHERME</creatorcontrib><creatorcontrib>SAIDE, OSWALDO L</creatorcontrib><creatorcontrib>LABIGALINI, ELIZEU</creatorcontrib><creatorcontrib>TACLA, CRISTIANE</creatorcontrib><creatorcontrib>MIRANDA, CLAUDIO T</creatorcontrib><creatorcontrib>STRASSMAN, RICK J</creatorcontrib><creatorcontrib>BOONE, KYLE B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The journal of nervous and mental disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GROB, CHARLES S</au><au>McKENNA, DENNIS J</au><au>CALLAWAY, JAMES C</au><au>BRITO, GLACUS S</au><au>NEVES, EDISON S</au><au>OBERLAENDER, GUILHERME</au><au>SAIDE, OSWALDO L</au><au>LABIGALINI, ELIZEU</au><au>TACLA, CRISTIANE</au><au>MIRANDA, CLAUDIO T</au><au>STRASSMAN, RICK J</au><au>BOONE, KYLE B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human Psychopharmacology of Hoasca, A Plant Hallucinogen Used in Ritual Context in Brazil</atitle><jtitle>The journal of nervous and mental disease</jtitle><addtitle>J Nerv Ment Dis</addtitle><date>1996-02</date><risdate>1996</risdate><volume>184</volume><issue>2</issue><spage>86</spage><epage>94</epage><pages>86-94</pages><issn>0022-3018</issn><eissn>1539-736X</eissn><abstract>A multinational, collaborative, biomedical investigation of the effects of hoasca (ayahuasca), a potent concoction of plant hallucinogens, was conducted in the Brazilian Amazon during the summer of 1993. 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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Brazil - epidemiology Cognition - drug effects Hallucinogens - pharmacology Harmine - pharmacology Humans Magic Male Medicine, Traditional Mental Disorders - diagnosis Mental Disorders - epidemiology Middle Aged Neuropsychological Tests Personality - drug effects Plants, Medicinal Psychiatric Status Rating Scales Religion and Medicine Substance-Related Disorders - diagnosis Substance-Related Disorders - psychology Tea Verbal Learning - drug effects |
| title | Human Psychopharmacology of Hoasca, A Plant Hallucinogen Used in Ritual Context in Brazil |
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