Family History of Alcoholism in Schizophrenia
Previous research has shown that family history of alcoholism (FHA) is associated with several aspects of the development and expression of alcohol use disorder in people who are not mentally ill. This study examined FHA in a group of 66 schizophrenic outpatients who were well characterized in terms...
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| Veröffentlicht in: | The journal of nervous and mental disease 1994-11, Vol.182 (11), p.651-655 |
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| container_end_page | 655 |
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| container_issue | 11 |
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| container_title | The journal of nervous and mental disease |
| container_volume | 182 |
| creator | NOORDSY, DOUGLAS L DRAKE, ROBERT E BIESANZ, JEREMY C McHUGO, GREGORY J |
| description | Previous research has shown that family history of alcoholism (FHA) is associated with several aspects of the development and expression of alcohol use disorder in people who are not mentally ill. This study examined FHA in a group of 66 schizophrenic outpatients who were well characterized in terms of their alcohol use and were followed prospectively in treatment for 4 years. The FHA-positive probands (42.4% of the group) were more likely to have alcohol use disorder. Contrary to our prediction, the relationship between FHA and alcoholism in the probands was significant for women but not for men. Among schizophrenic probands with alcoholism, positive FHA was associated with more severe alcoholism and with the use of other drugs. Probands with positive FHA also responded less well to alcoholism treatment than did probands with negative FHA. These exploratory findings have significant implications for understanding risk, for conducting assessment, and for studying treatment, but should be confirmed in larger and more representative samples of people with schizophrenia. |
| doi_str_mv | 10.1097/00005053-199411000-00009 |
| format | Article |
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This study examined FHA in a group of 66 schizophrenic outpatients who were well characterized in terms of their alcohol use and were followed prospectively in treatment for 4 years. The FHA-positive probands (42.4% of the group) were more likely to have alcohol use disorder. Contrary to our prediction, the relationship between FHA and alcoholism in the probands was significant for women but not for men. Among schizophrenic probands with alcoholism, positive FHA was associated with more severe alcoholism and with the use of other drugs. Probands with positive FHA also responded less well to alcoholism treatment than did probands with negative FHA. These exploratory findings have significant implications for understanding risk, for conducting assessment, and for studying treatment, but should be confirmed in larger and more representative samples of people with schizophrenia.</description><identifier>ISSN: 0022-3018</identifier><identifier>EISSN: 1539-736X</identifier><identifier>DOI: 10.1097/00005053-199411000-00009</identifier><identifier>PMID: 7964674</identifier><identifier>CODEN: JNMDAN</identifier><language>eng</language><publisher>Hagerstown, MD: Williams & Wilkins</publisher><subject>Adult and adolescent clinical studies ; Age of Onset ; Alcoholism - diagnosis ; Alcoholism - epidemiology ; Ambulatory Care ; Biological and medical sciences ; Comorbidity ; Family ; Female ; Follow-Up Studies ; Humans ; Male ; Medical sciences ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. 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All Rights Reserved.</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3849-320664f6bad44d2962d7c51888b991f998fab84898b3f8fc23c1369fa025249c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3330528$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7964674$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NOORDSY, DOUGLAS L</creatorcontrib><creatorcontrib>DRAKE, ROBERT E</creatorcontrib><creatorcontrib>BIESANZ, JEREMY C</creatorcontrib><creatorcontrib>McHUGO, GREGORY J</creatorcontrib><title>Family History of Alcoholism in Schizophrenia</title><title>The journal of nervous and mental disease</title><addtitle>J Nerv Ment Dis</addtitle><description>Previous research has shown that family history of alcoholism (FHA) is associated with several aspects of the development and expression of alcohol use disorder in people who are not mentally ill. This study examined FHA in a group of 66 schizophrenic outpatients who were well characterized in terms of their alcohol use and were followed prospectively in treatment for 4 years. The FHA-positive probands (42.4% of the group) were more likely to have alcohol use disorder. Contrary to our prediction, the relationship between FHA and alcoholism in the probands was significant for women but not for men. Among schizophrenic probands with alcoholism, positive FHA was associated with more severe alcoholism and with the use of other drugs. Probands with positive FHA also responded less well to alcoholism treatment than did probands with negative FHA. These exploratory findings have significant implications for understanding risk, for conducting assessment, and for studying treatment, but should be confirmed in larger and more representative samples of people with schizophrenia.</description><subject>Adult and adolescent clinical studies</subject><subject>Age of Onset</subject><subject>Alcoholism - diagnosis</subject><subject>Alcoholism - epidemiology</subject><subject>Ambulatory Care</subject><subject>Biological and medical sciences</subject><subject>Comorbidity</subject><subject>Family</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Schizophrenia</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenia - epidemiology</subject><subject>Severity of Illness Index</subject><subject>Sex Factors</subject><subject>Substance-Related Disorders - diagnosis</subject><subject>Substance-Related Disorders - epidemiology</subject><issn>0022-3018</issn><issn>1539-736X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEFLAzEQhYMotVZ_grAHr9Ekk81mjqVYKxQ8qOBtyWY3bDTtlqSl1F_v1tbenMswb94bmI-QjLN7zrB4YH3lLAfKESXn_UT3Ep6RIc8BaQHq45wMGROCAuP6klyl9MkYL0CyARkUqKQq5JDQqVn4sMtmPq27uMs6l42D7dou-LTI_DJ7ta3_7lZtbJbeXJMLZ0Jqbo59RN6nj2-TGZ2_PD1PxnNqQUukIJhS0qnK1FLWApWoC5tzrXWFyB2idqbSUqOuwGlnBVgOCp1hIhcSLYyIPty1sUspNq5cRb8wcVdyVu4BlH8AyhOAXwn76O0hutpUi6Y-BY8f9_u7494ka4KLZml9OtkAgOVC9zZ5sG27sG5i-gqbbRPLtjFh3Zb_4Ycf0ipwcw</recordid><startdate>199411</startdate><enddate>199411</enddate><creator>NOORDSY, DOUGLAS L</creator><creator>DRAKE, ROBERT E</creator><creator>BIESANZ, JEREMY C</creator><creator>McHUGO, GREGORY J</creator><general>Williams & Wilkins</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199411</creationdate><title>Family History of Alcoholism in Schizophrenia</title><author>NOORDSY, DOUGLAS L ; DRAKE, ROBERT E ; BIESANZ, JEREMY C ; McHUGO, GREGORY J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3849-320664f6bad44d2962d7c51888b991f998fab84898b3f8fc23c1369fa025249c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Age of Onset</topic><topic>Alcoholism - diagnosis</topic><topic>Alcoholism - epidemiology</topic><topic>Ambulatory Care</topic><topic>Biological and medical sciences</topic><topic>Comorbidity</topic><topic>Family</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Schizophrenia</topic><topic>Schizophrenia - diagnosis</topic><topic>Schizophrenia - epidemiology</topic><topic>Severity of Illness Index</topic><topic>Sex Factors</topic><topic>Substance-Related Disorders - diagnosis</topic><topic>Substance-Related Disorders - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NOORDSY, DOUGLAS L</creatorcontrib><creatorcontrib>DRAKE, ROBERT E</creatorcontrib><creatorcontrib>BIESANZ, JEREMY C</creatorcontrib><creatorcontrib>McHUGO, GREGORY J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The journal of nervous and mental disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NOORDSY, DOUGLAS L</au><au>DRAKE, ROBERT E</au><au>BIESANZ, JEREMY C</au><au>McHUGO, GREGORY J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Family History of Alcoholism in Schizophrenia</atitle><jtitle>The journal of nervous and mental disease</jtitle><addtitle>J Nerv Ment Dis</addtitle><date>1994-11</date><risdate>1994</risdate><volume>182</volume><issue>11</issue><spage>651</spage><epage>655</epage><pages>651-655</pages><issn>0022-3018</issn><eissn>1539-736X</eissn><coden>JNMDAN</coden><abstract>Previous research has shown that family history of alcoholism (FHA) is associated with several aspects of the development and expression of alcohol use disorder in people who are not mentally ill. This study examined FHA in a group of 66 schizophrenic outpatients who were well characterized in terms of their alcohol use and were followed prospectively in treatment for 4 years. The FHA-positive probands (42.4% of the group) were more likely to have alcohol use disorder. Contrary to our prediction, the relationship between FHA and alcoholism in the probands was significant for women but not for men. Among schizophrenic probands with alcoholism, positive FHA was associated with more severe alcoholism and with the use of other drugs. Probands with positive FHA also responded less well to alcoholism treatment than did probands with negative FHA. These exploratory findings have significant implications for understanding risk, for conducting assessment, and for studying treatment, but should be confirmed in larger and more representative samples of people with schizophrenia.</abstract><cop>Hagerstown, MD</cop><pub>Williams & Wilkins</pub><pmid>7964674</pmid><doi>10.1097/00005053-199411000-00009</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0022-3018 |
| ispartof | The journal of nervous and mental disease, 1994-11, Vol.182 (11), p.651-655 |
| issn | 0022-3018 1539-736X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult and adolescent clinical studies Age of Onset Alcoholism - diagnosis Alcoholism - epidemiology Ambulatory Care Biological and medical sciences Comorbidity Family Female Follow-Up Studies Humans Male Medical sciences Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Schizophrenia Schizophrenia - diagnosis Schizophrenia - epidemiology Severity of Illness Index Sex Factors Substance-Related Disorders - diagnosis Substance-Related Disorders - epidemiology |
| title | Family History of Alcoholism in Schizophrenia |
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