Progression of Symptoms in Neuroleptic Malignant Syndrome
The neuroleptic malignant syndrome (NMS) is a rare but potentially fatal disorder characterized by mental-status changes, muscle rigidity, hyperthermia, and autonomic dysfunction. Systematic examination of early signs and the progression of symptoms in NMS may be worthwhile to facilitate prompt reco...
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| Veröffentlicht in: | The journal of nervous and mental disease 1994-03, Vol.182 (3), p.168-173 |
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| container_issue | 3 |
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| container_title | The journal of nervous and mental disease |
| container_volume | 182 |
| creator | VELAMOOR, VARADARAJ R NORMAN, ROSS M. G CAROFF, STANLEY N MANN, STEPHAN C SULLIVAN, KENNETH A ANTELO, R EDUARDO |
| description | The neuroleptic malignant syndrome (NMS) is a rare but potentially fatal disorder characterized by mental-status changes, muscle rigidity, hyperthermia, and autonomic dysfunction. Systematic examination of early signs and the progression of symptoms in NMS may be worthwhile to facilitate prompt recognition and interventions to abort the syndrome in its incipient stage. The authors present the results of a preliminary review of the temporal sequence of the four predominant signs of NMS as described in 340 clinical reports of NMS in the literature. Of all order implications, 70.5% were consistent with the sequence of mentalstatus changes, rigidity, hyperthermia, and autonomic dysfunction. Changes in either mental status or rigidity were the initial manifestations of NMS in 82.3% of cases with a single presenting sign and were significantly more likely to be observed before hyperthermia and autonomic dysfunction. Methodological limitations of these data and clinical implications are discussed. |
| doi_str_mv | 10.1097/00005053-199403000-00007 |
| format | Article |
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G ; CAROFF, STANLEY N ; MANN, STEPHAN C ; SULLIVAN, KENNETH A ; ANTELO, R EDUARDO</creator><creatorcontrib>VELAMOOR, VARADARAJ R ; NORMAN, ROSS M. G ; CAROFF, STANLEY N ; MANN, STEPHAN C ; SULLIVAN, KENNETH A ; ANTELO, R EDUARDO</creatorcontrib><description>The neuroleptic malignant syndrome (NMS) is a rare but potentially fatal disorder characterized by mental-status changes, muscle rigidity, hyperthermia, and autonomic dysfunction. Systematic examination of early signs and the progression of symptoms in NMS may be worthwhile to facilitate prompt recognition and interventions to abort the syndrome in its incipient stage. The authors present the results of a preliminary review of the temporal sequence of the four predominant signs of NMS as described in 340 clinical reports of NMS in the literature. Of all order implications, 70.5% were consistent with the sequence of mentalstatus changes, rigidity, hyperthermia, and autonomic dysfunction. Changes in either mental status or rigidity were the initial manifestations of NMS in 82.3% of cases with a single presenting sign and were significantly more likely to be observed before hyperthermia and autonomic dysfunction. Methodological limitations of these data and clinical implications are discussed.</description><identifier>ISSN: 0022-3018</identifier><identifier>EISSN: 1539-736X</identifier><identifier>DOI: 10.1097/00005053-199403000-00007</identifier><identifier>PMID: 7906709</identifier><identifier>CODEN: JNMDAN</identifier><language>eng</language><publisher>Hagerstown, MD: Williams & Wilkins</publisher><subject>Adolescent ; Adult ; Aged ; Antipsychotic Agents - adverse effects ; Autonomic Nervous System Diseases - diagnosis ; Biological and medical sciences ; Child ; Child, Preschool ; Drug toxicity and drugs side effects treatment ; Female ; Fever - diagnosis ; Follow-Up Studies ; Humans ; Infant ; Male ; Medical sciences ; Mental Disorders - diagnosis ; Middle Aged ; Muscle Rigidity - diagnosis ; Neuroleptic Malignant Syndrome - diagnosis ; Neuroleptic Malignant Syndrome - etiology ; Pharmacology. Drug treatments ; Retrospective Studies ; Time Factors ; Toxicity: nervous system and muscle</subject><ispartof>The journal of nervous and mental disease, 1994-03, Vol.182 (3), p.168-173</ispartof><rights>Williams & Wilkins 1994. All Rights Reserved.</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4507-7388c00634f3021e345db3108486d8b2efaf1d7417c21b1541aa55411ebbf923</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3975686$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7906709$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VELAMOOR, VARADARAJ R</creatorcontrib><creatorcontrib>NORMAN, ROSS M. 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Of all order implications, 70.5% were consistent with the sequence of mentalstatus changes, rigidity, hyperthermia, and autonomic dysfunction. Changes in either mental status or rigidity were the initial manifestations of NMS in 82.3% of cases with a single presenting sign and were significantly more likely to be observed before hyperthermia and autonomic dysfunction. Methodological limitations of these data and clinical implications are discussed.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Antipsychotic Agents - adverse effects</subject><subject>Autonomic Nervous System Diseases - diagnosis</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>Fever - diagnosis</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mental Disorders - diagnosis</subject><subject>Middle Aged</subject><subject>Muscle Rigidity - diagnosis</subject><subject>Neuroleptic Malignant Syndrome - diagnosis</subject><subject>Neuroleptic Malignant Syndrome - etiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Retrospective Studies</subject><subject>Time Factors</subject><subject>Toxicity: nervous system and muscle</subject><issn>0022-3018</issn><issn>1539-736X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UU1PwzAMjRBojMFPQOqBa8FukiY5IsSXND4kduBWpW2yFdpmSjpN-_dkbOyGD7Zsv2fZz4QkCNcIStxANA6cpqgUAxqzdFsSR2SMnKpU0PzzmIwBsiylgPKUnIXwBYCCMhiRkVCQC1Bjot69m3sTQuP6xNnkY9MtB9eFpOmTV7PyrjXLoamSF9028173Q0T0tXedOScnVrfBXOzjhMwe7md3T-n07fH57naaVoyDiJtIWQHklFkKGRrKeF1SBMlkXssyM1ZbrAVDUWVYImeoNY8eTVlaldEJkbuxlXcheGOLpW867TcFQrHVovjTojho8VsSkXq5oy5XZWfqA3F_fOxf7fs6VLq1XvdVEw4wqgTPZR5hbAdbu3YwPny3q7XxxcLodlgU_32C_gBblXTr</recordid><startdate>199403</startdate><enddate>199403</enddate><creator>VELAMOOR, VARADARAJ R</creator><creator>NORMAN, ROSS M. 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G ; CAROFF, STANLEY N ; MANN, STEPHAN C ; SULLIVAN, KENNETH A ; ANTELO, R EDUARDO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4507-7388c00634f3021e345db3108486d8b2efaf1d7417c21b1541aa55411ebbf923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Antipsychotic Agents - adverse effects</topic><topic>Autonomic Nervous System Diseases - diagnosis</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Female</topic><topic>Fever - diagnosis</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mental Disorders - diagnosis</topic><topic>Middle Aged</topic><topic>Muscle Rigidity - diagnosis</topic><topic>Neuroleptic Malignant Syndrome - diagnosis</topic><topic>Neuroleptic Malignant Syndrome - etiology</topic><topic>Pharmacology. Drug treatments</topic><topic>Retrospective Studies</topic><topic>Time Factors</topic><topic>Toxicity: nervous system and muscle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VELAMOOR, VARADARAJ R</creatorcontrib><creatorcontrib>NORMAN, ROSS M. 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The authors present the results of a preliminary review of the temporal sequence of the four predominant signs of NMS as described in 340 clinical reports of NMS in the literature. Of all order implications, 70.5% were consistent with the sequence of mentalstatus changes, rigidity, hyperthermia, and autonomic dysfunction. Changes in either mental status or rigidity were the initial manifestations of NMS in 82.3% of cases with a single presenting sign and were significantly more likely to be observed before hyperthermia and autonomic dysfunction. Methodological limitations of these data and clinical implications are discussed.</abstract><cop>Hagerstown, MD</cop><pub>Williams & Wilkins</pub><pmid>7906709</pmid><doi>10.1097/00005053-199403000-00007</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0022-3018 |
| ispartof | The journal of nervous and mental disease, 1994-03, Vol.182 (3), p.168-173 |
| issn | 0022-3018 1539-736X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Adult Aged Antipsychotic Agents - adverse effects Autonomic Nervous System Diseases - diagnosis Biological and medical sciences Child Child, Preschool Drug toxicity and drugs side effects treatment Female Fever - diagnosis Follow-Up Studies Humans Infant Male Medical sciences Mental Disorders - diagnosis Middle Aged Muscle Rigidity - diagnosis Neuroleptic Malignant Syndrome - diagnosis Neuroleptic Malignant Syndrome - etiology Pharmacology. Drug treatments Retrospective Studies Time Factors Toxicity: nervous system and muscle |
| title | Progression of Symptoms in Neuroleptic Malignant Syndrome |
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