The nitric oxide synthase inhibitor L-NMMA potentiates noradrenaline-induced vasoconstriction: effects of the alpha2-receptor antagonist yohimbine

OBJECTIVEAlpha2-adrenoceptors can be found both on vascular smooth muscle cells and on the endothelium, where they exert opposing effects on vascular tone. In vitro, the stimulation of α2-adrenoceptors on endothelial cells leads to the release of vasodilating substances like nitric oxide (NO) and pr...

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