Angiotensin converting enzyme inhibition in normotensive type II diabetics with persistent mild proteinuria
To evaluate the effect of enalapril on proteinuria, 16 normotensive type II diabetics with persistent proteinuria were studied. At random, the patients were allocated to enalapril (5 mg once a day) or placebo, in a double-blind fashion, for 12 months. Blood pressure, heart rate, urinary albumin excr...
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| Veröffentlicht in: | Journal of hypertension 1989-12, Vol.7 Suppl 6 (6), p.S314-315 |
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| creator | Stornello, Michele Valvo, Enrico V Scapellato, Luigi |
| description | To evaluate the effect of enalapril on proteinuria, 16 normotensive type II diabetics with persistent proteinuria were studied. At random, the patients were allocated to enalapril (5 mg once a day) or placebo, in a double-blind fashion, for 12 months. Blood pressure, heart rate, urinary albumin excretion, plasma renin activity and aldosterone, blood glucose, serum fructosamine, urine urea and body weight were checked monthly during the run-in period and every 2 months during the treatment period. The kidney function was studied at the beginning of the study and during the sixth and 12th months. Enalapril decreased urinary albumin excretion in our patients in the absence of any effect on blood pressure and kidney function.Our data may be interpreted on the basis of a direct vascular effect of enalapril that is probably related to a tissue mechanism consisting of reduced angiotensin formation, increased kinins, or both, or of other unknown factors. |
| doi_str_mv | 10.1097/00004872-198900076-00153 |
| format | Article |
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At random, the patients were allocated to enalapril (5 mg once a day) or placebo, in a double-blind fashion, for 12 months. Blood pressure, heart rate, urinary albumin excretion, plasma renin activity and aldosterone, blood glucose, serum fructosamine, urine urea and body weight were checked monthly during the run-in period and every 2 months during the treatment period. The kidney function was studied at the beginning of the study and during the sixth and 12th months. Enalapril decreased urinary albumin excretion in our patients in the absence of any effect on blood pressure and kidney function.Our data may be interpreted on the basis of a direct vascular effect of enalapril that is probably related to a tissue mechanism consisting of reduced angiotensin formation, increased kinins, or both, or of other unknown factors.</description><identifier>ISSN: 0263-6352</identifier><identifier>ISSN: 0952-1178</identifier><identifier>EISSN: 1473-5598</identifier><identifier>DOI: 10.1097/00004872-198900076-00153</identifier><identifier>PMID: 2561147</identifier><identifier>CODEN: JOHYD3</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Albuminuria - drug therapy ; Albuminuria - physiopathology ; Albuminuria - urine ; Antihypertensive agents ; Biological and medical sciences ; Blood Pressure - drug effects ; Blood Pressure - physiology ; Cardiovascular system ; Diabetes Mellitus, Type 2 - drug therapy ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetes Mellitus, Type 2 - urine ; Diabetic Nephropathies - drug therapy ; Diabetic Nephropathies - physiopathology ; Diabetic Nephropathies - urine ; Double-Blind Method ; Enalapril - therapeutic use ; Heart Rate - drug effects ; Heart Rate - physiology ; Humans ; Medical sciences ; Pharmacology. Drug treatments ; Proteinuria - drug therapy ; Proteinuria - physiopathology ; Proteinuria - urine ; Randomized Controlled Trials as Topic</subject><ispartof>Journal of hypertension, 1989-12, Vol.7 Suppl 6 (6), p.S314-315</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3853-79d25ef40e289b71ef775cee7162d5f3240fada35ce2687f3020b358e398f5e73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,23930,23931,25140,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19809655$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2561147$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stornello, Michele</creatorcontrib><creatorcontrib>Valvo, Enrico V</creatorcontrib><creatorcontrib>Scapellato, Luigi</creatorcontrib><title>Angiotensin converting enzyme inhibition in normotensive type II diabetics with persistent mild proteinuria</title><title>Journal of hypertension</title><addtitle>J Hypertens Suppl</addtitle><description>To evaluate the effect of enalapril on proteinuria, 16 normotensive type II diabetics with persistent proteinuria were studied. At random, the patients were allocated to enalapril (5 mg once a day) or placebo, in a double-blind fashion, for 12 months. Blood pressure, heart rate, urinary albumin excretion, plasma renin activity and aldosterone, blood glucose, serum fructosamine, urine urea and body weight were checked monthly during the run-in period and every 2 months during the treatment period. The kidney function was studied at the beginning of the study and during the sixth and 12th months. Enalapril decreased urinary albumin excretion in our patients in the absence of any effect on blood pressure and kidney function.Our data may be interpreted on the basis of a direct vascular effect of enalapril that is probably related to a tissue mechanism consisting of reduced angiotensin formation, increased kinins, or both, or of other unknown factors.</description><subject>Albuminuria - drug therapy</subject><subject>Albuminuria - physiopathology</subject><subject>Albuminuria - urine</subject><subject>Antihypertensive agents</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Blood Pressure - physiology</subject><subject>Cardiovascular system</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetes Mellitus, Type 2 - urine</subject><subject>Diabetic Nephropathies - drug therapy</subject><subject>Diabetic Nephropathies - physiopathology</subject><subject>Diabetic Nephropathies - urine</subject><subject>Double-Blind Method</subject><subject>Enalapril - therapeutic use</subject><subject>Heart Rate - drug effects</subject><subject>Heart Rate - physiology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Proteinuria - drug therapy</subject><subject>Proteinuria - physiopathology</subject><subject>Proteinuria - urine</subject><subject>Randomized Controlled Trials as Topic</subject><issn>0263-6352</issn><issn>0952-1178</issn><issn>1473-5598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kT1PwzAQhi0EglL4CUheGAP-iGN7RIiPSkgsMEdOcqaGxIlsl6r8egwtMHHLnXzPe8NjhDAlF5RoeUlylUqygmql8yyrghAq-B6a0VLyQgit9tGMsIoXFRfsCB3H-JpBpSU_RIdMVDSDM_R25V_cmMBH53E7-ncIyfkXDP5jMwB2fukal9zo84j9GIYt-w44bSbAiwXunGkguTbitUtLPEGILmYo4cH1HZ5CTji_Cs6coANr-ginuz5Hz7c3T9f3xcPj3eL66qFouRK8kLpjAmxJgCndSApWStECSFqxTljOSmJNZ3h-Y5WSlhNGGi4UcK2sAMnnSG3vtmGMMYCtp-AGEzY1JfWXvvpHX_2rr_7Wl6Nn2-i0agbofoM7X3l_vtub2JreBuNbF__ua0V0JUTmyi23HvuUjbz1qzWEegmmT8v6v9_jn4VKie4</recordid><startdate>19891201</startdate><enddate>19891201</enddate><creator>Stornello, Michele</creator><creator>Valvo, Enrico V</creator><creator>Scapellato, Luigi</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19891201</creationdate><title>Angiotensin converting enzyme inhibition in normotensive type II diabetics with persistent mild proteinuria</title><author>Stornello, Michele ; Valvo, Enrico V ; Scapellato, Luigi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3853-79d25ef40e289b71ef775cee7162d5f3240fada35ce2687f3020b358e398f5e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Albuminuria - drug therapy</topic><topic>Albuminuria - physiopathology</topic><topic>Albuminuria - urine</topic><topic>Antihypertensive agents</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Blood Pressure - physiology</topic><topic>Cardiovascular system</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Diabetes Mellitus, Type 2 - urine</topic><topic>Diabetic Nephropathies - drug therapy</topic><topic>Diabetic Nephropathies - physiopathology</topic><topic>Diabetic Nephropathies - urine</topic><topic>Double-Blind Method</topic><topic>Enalapril - therapeutic use</topic><topic>Heart Rate - drug effects</topic><topic>Heart Rate - physiology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Proteinuria - drug therapy</topic><topic>Proteinuria - physiopathology</topic><topic>Proteinuria - urine</topic><topic>Randomized Controlled Trials as Topic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stornello, Michele</creatorcontrib><creatorcontrib>Valvo, Enrico V</creatorcontrib><creatorcontrib>Scapellato, Luigi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stornello, Michele</au><au>Valvo, Enrico V</au><au>Scapellato, Luigi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Angiotensin converting enzyme inhibition in normotensive type II diabetics with persistent mild proteinuria</atitle><jtitle>Journal of hypertension</jtitle><addtitle>J Hypertens Suppl</addtitle><date>1989-12-01</date><risdate>1989</risdate><volume>7 Suppl 6</volume><issue>6</issue><spage>S314</spage><epage>315</epage><pages>S314-315</pages><issn>0263-6352</issn><issn>0952-1178</issn><eissn>1473-5598</eissn><coden>JOHYD3</coden><abstract>To evaluate the effect of enalapril on proteinuria, 16 normotensive type II diabetics with persistent proteinuria were studied. At random, the patients were allocated to enalapril (5 mg once a day) or placebo, in a double-blind fashion, for 12 months. Blood pressure, heart rate, urinary albumin excretion, plasma renin activity and aldosterone, blood glucose, serum fructosamine, urine urea and body weight were checked monthly during the run-in period and every 2 months during the treatment period. The kidney function was studied at the beginning of the study and during the sixth and 12th months. Enalapril decreased urinary albumin excretion in our patients in the absence of any effect on blood pressure and kidney function.Our data may be interpreted on the basis of a direct vascular effect of enalapril that is probably related to a tissue mechanism consisting of reduced angiotensin formation, increased kinins, or both, or of other unknown factors.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>2561147</pmid><doi>10.1097/00004872-198900076-00153</doi></addata></record> |
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| ispartof | Journal of hypertension, 1989-12, Vol.7 Suppl 6 (6), p.S314-315 |
| issn | 0263-6352 0952-1178 1473-5598 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Albuminuria - drug therapy Albuminuria - physiopathology Albuminuria - urine Antihypertensive agents Biological and medical sciences Blood Pressure - drug effects Blood Pressure - physiology Cardiovascular system Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - physiopathology Diabetes Mellitus, Type 2 - urine Diabetic Nephropathies - drug therapy Diabetic Nephropathies - physiopathology Diabetic Nephropathies - urine Double-Blind Method Enalapril - therapeutic use Heart Rate - drug effects Heart Rate - physiology Humans Medical sciences Pharmacology. Drug treatments Proteinuria - drug therapy Proteinuria - physiopathology Proteinuria - urine Randomized Controlled Trials as Topic |
| title | Angiotensin converting enzyme inhibition in normotensive type II diabetics with persistent mild proteinuria |
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