Regulation of Na+-K+ pump activity in erythrocytes and blood pressure in anephric rats
This study was designed to explore factors involved in the regulation of Na-K pumps in erythrocytes and blood pressure in anephric Sprague-Dawley female rats. Twenty-four hours following bilateral nephrectomy, the rats were given a 1-h infusion of 1 ml of either 0.9% or 5.4% saline, or 5% or 30% glu...
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| Veröffentlicht in: | Journal of hypertension 1988-12, Vol.6 (4), p.S264-265 |
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| creator | Birbari, Adil E Hajj-Ali, Ali F Mukaddam-Daher, Suhayla S Jirjus, Abdo R |
| description | This study was designed to explore factors involved in the regulation of Na-K pumps in erythrocytes and blood pressure in anephric Sprague-Dawley female rats. Twenty-four hours following bilateral nephrectomy, the rats were given a 1-h infusion of 1 ml of either 0.9% or 5.4% saline, or 5% or 30% glucose. At the completion of the infusion, tail blood pressure was determined and blood was drawn for the measurement of the ouabain-furosemide-sensitive sodium efflux rate constant in erythrocytes. Infusion of 5.4% saline or 30% glucose caused a significant reduction in the erythrocyte sodium efflux rate constant, more pronounced with the former, and an elevation in blood pressure. Nephrectomy or infusion of 0.9% saline or 5% glucose had no effect on either parameter. These findings suggest that in anephric rats (1) extracellular fluid hyperosmolality rather than extracellular fluid volume expansion inhibits the Na-K pump in all cells; (2) a Na-K pump inhibitor is involved in the genesis of hypertension. |
| doi_str_mv | 10.1097/00004872-198812040-00080 |
| format | Article |
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Twenty-four hours following bilateral nephrectomy, the rats were given a 1-h infusion of 1 ml of either 0.9% or 5.4% saline, or 5% or 30% glucose. At the completion of the infusion, tail blood pressure was determined and blood was drawn for the measurement of the ouabain-furosemide-sensitive sodium efflux rate constant in erythrocytes. Infusion of 5.4% saline or 30% glucose caused a significant reduction in the erythrocyte sodium efflux rate constant, more pronounced with the former, and an elevation in blood pressure. Nephrectomy or infusion of 0.9% saline or 5% glucose had no effect on either parameter. These findings suggest that in anephric rats (1) extracellular fluid hyperosmolality rather than extracellular fluid volume expansion inhibits the Na-K pump in all cells; (2) a Na-K pump inhibitor is involved in the genesis of hypertension.</description><identifier>ISSN: 0263-6352</identifier><identifier>ISSN: 0952-1178</identifier><identifier>EISSN: 1473-5598</identifier><identifier>DOI: 10.1097/00004872-198812040-00080</identifier><identifier>PMID: 2853734</identifier><language>eng</language><publisher>England: Lippincott-Raven Publishers</publisher><subject>Animals ; Erythrocytes - metabolism ; Female ; Furosemide - pharmacology ; Hypertension, Renal - metabolism ; Nephrectomy ; Ouabain - pharmacology ; Rats ; Sodium - metabolism ; Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors ; Sodium-Potassium-Exchanging ATPase - metabolism</subject><ispartof>Journal of hypertension, 1988-12, Vol.6 (4), p.S264-265</ispartof><rights>Lippincott-Raven Publishers.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2853734$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Birbari, Adil E</creatorcontrib><creatorcontrib>Hajj-Ali, Ali F</creatorcontrib><creatorcontrib>Mukaddam-Daher, Suhayla S</creatorcontrib><creatorcontrib>Jirjus, Abdo R</creatorcontrib><title>Regulation of Na+-K+ pump activity in erythrocytes and blood pressure in anephric rats</title><title>Journal of hypertension</title><addtitle>J Hypertens Suppl</addtitle><description>This study was designed to explore factors involved in the regulation of Na-K pumps in erythrocytes and blood pressure in anephric Sprague-Dawley female rats. Twenty-four hours following bilateral nephrectomy, the rats were given a 1-h infusion of 1 ml of either 0.9% or 5.4% saline, or 5% or 30% glucose. At the completion of the infusion, tail blood pressure was determined and blood was drawn for the measurement of the ouabain-furosemide-sensitive sodium efflux rate constant in erythrocytes. Infusion of 5.4% saline or 30% glucose caused a significant reduction in the erythrocyte sodium efflux rate constant, more pronounced with the former, and an elevation in blood pressure. Nephrectomy or infusion of 0.9% saline or 5% glucose had no effect on either parameter. These findings suggest that in anephric rats (1) extracellular fluid hyperosmolality rather than extracellular fluid volume expansion inhibits the Na-K pump in all cells; (2) a Na-K pump inhibitor is involved in the genesis of hypertension.</description><subject>Animals</subject><subject>Erythrocytes - metabolism</subject><subject>Female</subject><subject>Furosemide - pharmacology</subject><subject>Hypertension, Renal - metabolism</subject><subject>Nephrectomy</subject><subject>Ouabain - pharmacology</subject><subject>Rats</subject><subject>Sodium - metabolism</subject><subject>Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors</subject><subject>Sodium-Potassium-Exchanging ATPase - metabolism</subject><issn>0263-6352</issn><issn>0952-1178</issn><issn>1473-5598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1OwzAQhC0EKqXwCEi-VwbHdmLniBB_ogIJAVfLidckkDaR7VDl7Ulp6Y29rLQzs4dvEMIJvUhoLi_pOEJJRpJcqYRRQcl4UfQATRMhOUnTXB2iKWUZJxlP2TE6CeFzY8kln6AJUymXXEzR-wt89I2JdbvCrcNPZk4e57jrlx02Zay_6zjgeoXBD7HybTlECNisLC6atrW48xBC72FjMSvoKl-X2JsYTtGRM02As92eobfbm9fre7J4vnu4vlqQknFGCUiWC6G4Mxm3QmSKg7FWFtwVGaUFgxSEKxInBEibS5fK3FCZWmmYLIAzPkNq-7f0bQgenO58vTR-0AnVG1L6j5Tek9K_pMbo-Tba9cUS7D64QzPqYquv2yaCD19NvwavKzBNrPR_BfAfmblzsQ</recordid><startdate>198812</startdate><enddate>198812</enddate><creator>Birbari, Adil E</creator><creator>Hajj-Ali, Ali F</creator><creator>Mukaddam-Daher, Suhayla S</creator><creator>Jirjus, Abdo R</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>198812</creationdate><title>Regulation of Na+-K+ pump activity in erythrocytes and blood pressure in anephric rats</title><author>Birbari, Adil E ; Hajj-Ali, Ali F ; Mukaddam-Daher, Suhayla S ; Jirjus, Abdo R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2320-e7294483fa63d44683eadd7b3fb600b2e5e4fb1f44e7d97f579a075d7a27be323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Erythrocytes - metabolism</topic><topic>Female</topic><topic>Furosemide - pharmacology</topic><topic>Hypertension, Renal - metabolism</topic><topic>Nephrectomy</topic><topic>Ouabain - pharmacology</topic><topic>Rats</topic><topic>Sodium - metabolism</topic><topic>Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors</topic><topic>Sodium-Potassium-Exchanging ATPase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Birbari, Adil E</creatorcontrib><creatorcontrib>Hajj-Ali, Ali F</creatorcontrib><creatorcontrib>Mukaddam-Daher, Suhayla S</creatorcontrib><creatorcontrib>Jirjus, Abdo R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Birbari, Adil E</au><au>Hajj-Ali, Ali F</au><au>Mukaddam-Daher, Suhayla S</au><au>Jirjus, Abdo R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of Na+-K+ pump activity in erythrocytes and blood pressure in anephric rats</atitle><jtitle>Journal of hypertension</jtitle><addtitle>J Hypertens Suppl</addtitle><date>1988-12</date><risdate>1988</risdate><volume>6</volume><issue>4</issue><spage>S264</spage><epage>265</epage><pages>S264-265</pages><issn>0263-6352</issn><issn>0952-1178</issn><eissn>1473-5598</eissn><abstract>This study was designed to explore factors involved in the regulation of Na-K pumps in erythrocytes and blood pressure in anephric Sprague-Dawley female rats. Twenty-four hours following bilateral nephrectomy, the rats were given a 1-h infusion of 1 ml of either 0.9% or 5.4% saline, or 5% or 30% glucose. At the completion of the infusion, tail blood pressure was determined and blood was drawn for the measurement of the ouabain-furosemide-sensitive sodium efflux rate constant in erythrocytes. Infusion of 5.4% saline or 30% glucose caused a significant reduction in the erythrocyte sodium efflux rate constant, more pronounced with the former, and an elevation in blood pressure. Nephrectomy or infusion of 0.9% saline or 5% glucose had no effect on either parameter. These findings suggest that in anephric rats (1) extracellular fluid hyperosmolality rather than extracellular fluid volume expansion inhibits the Na-K pump in all cells; (2) a Na-K pump inhibitor is involved in the genesis of hypertension.</abstract><cop>England</cop><pub>Lippincott-Raven Publishers</pub><pmid>2853734</pmid><doi>10.1097/00004872-198812040-00080</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0263-6352 |
| ispartof | Journal of hypertension, 1988-12, Vol.6 (4), p.S264-265 |
| issn | 0263-6352 0952-1178 1473-5598 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Animals Erythrocytes - metabolism Female Furosemide - pharmacology Hypertension, Renal - metabolism Nephrectomy Ouabain - pharmacology Rats Sodium - metabolism Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors Sodium-Potassium-Exchanging ATPase - metabolism |
| title | Regulation of Na+-K+ pump activity in erythrocytes and blood pressure in anephric rats |
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