The behavioural toxicity of the selective serotonin reuptake inhibitors
The serotonin reuptake inhibitors (SSRIs) are generally better tolerated than the traditional tricyclic antidepressants (TCAs) in the treatment of major depression. In particular the SSRIs are relatively free from cognitive and psychomotor effects likely to cause behavioural toxicity. Behavioural to...
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| Veröffentlicht in: | International clinical psychopharmacology 1995-01, Vol.9 Suppl 4, p.13-18 |
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| container_title | International clinical psychopharmacology |
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| creator | Hindmarch, I |
| description | The serotonin reuptake inhibitors (SSRIs) are generally better tolerated than the traditional tricyclic antidepressants (TCAs) in the treatment of major depression. In particular the SSRIs are relatively free from cognitive and psychomotor effects likely to cause behavioural toxicity. Behavioural toxicity is studied using a battery of psychometric assessments. This paper discusses the effects of the TCAs and SSRIs on two such assessments, choice reaction time (CRT) and critical flicker fusion threshold (CFFT). CRT measures psychomotor speed, and CFFT assesses the information processing capacity of the CNS. The behavioural toxicity associated with the traditional TCAs can lead to an increased accident risk, whereas the SSRIs are not associated with such effects. Clinically relevant differences in the behavioural toxicity of the SSRIs are highlighted. |
| doi_str_mv | 10.1097/00004850-199501004-00002 |
| format | Article |
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Clinically relevant differences in the behavioural toxicity of the SSRIs are highlighted.</description><subject>Accidents, Traffic - statistics & numerical data</subject><subject>Antidepressive Agents, Tricyclic - adverse effects</subject><subject>Automobile Driving</subject><subject>Biological and medical sciences</subject><subject>Cognition Disorders - chemically induced</subject><subject>Depressive Disorder - drug therapy</subject><subject>Dothiepin - adverse effects</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Flicker Fusion - drug effects</subject><subject>Fluvoxamine - adverse effects</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychomotor Performance - drug effects</subject><subject>Reaction Time - drug effects</subject><subject>Serotonin Uptake Inhibitors - adverse effects</subject><subject>Time Factors</subject><subject>Toxicity: nervous system and muscle</subject><issn>0268-1315</issn><issn>1473-5857</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1OwzAQhC0EKqHwCEg5cA34N7GPqIKCVIlLOUdObCumaVzZTkvfHpeW3vBl7Z2ZlfUtADmCjwiK6gmmQzmDBRKCQZQexaGFL0CGaEUKxll1CTKIS14ggtg1uAnhKxkgEnQCJlWJMUc8A_Nlp_NGd3Jr3ehln0f3bVsb97kzeUxa0L1uo90ebt5FN9gh93rcRLnSuR0629jofLgFV0b2Qd-d6hR8vr4sZ2_F4mP-PnteFC3hFBdGp-8hJgwvJVaMUKgahapSYFFxwhBXDELFG2qoMgqyCje0LAXTRjWYIkOmgB_ntt6F4LWpN96upd_XCNYHNPUfmvqM5reFU_T-GN2MzVqrc_DEIukPJ12GVvbGy6G14WwjtKQ4sZ0CerTtXB-1D6t-3Glfd1r2sav_Wwz5AX7uewY</recordid><startdate>199501</startdate><enddate>199501</enddate><creator>Hindmarch, I</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199501</creationdate><title>The behavioural toxicity of the selective serotonin reuptake inhibitors</title><author>Hindmarch, I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3842-fe147159f86a2d5340dbd176929783518d500d8b4f4dfd0572b46695efdb241f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Accidents, Traffic - statistics & numerical data</topic><topic>Antidepressive Agents, Tricyclic - adverse effects</topic><topic>Automobile Driving</topic><topic>Biological and medical sciences</topic><topic>Cognition Disorders - chemically induced</topic><topic>Depressive Disorder - drug therapy</topic><topic>Dothiepin - adverse effects</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Flicker Fusion - drug effects</topic><topic>Fluvoxamine - adverse effects</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychomotor Performance - drug effects</topic><topic>Reaction Time - drug effects</topic><topic>Serotonin Uptake Inhibitors - adverse effects</topic><topic>Time Factors</topic><topic>Toxicity: nervous system and muscle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hindmarch, I</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>International clinical psychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hindmarch, I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The behavioural toxicity of the selective serotonin reuptake inhibitors</atitle><jtitle>International clinical psychopharmacology</jtitle><addtitle>Int Clin Psychopharmacol</addtitle><date>1995-01</date><risdate>1995</risdate><volume>9 Suppl 4</volume><spage>13</spage><epage>18</epage><pages>13-18</pages><issn>0268-1315</issn><eissn>1473-5857</eissn><abstract>The serotonin reuptake inhibitors (SSRIs) are generally better tolerated than the traditional tricyclic antidepressants (TCAs) in the treatment of major depression. 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| identifier | ISSN: 0268-1315 |
| ispartof | International clinical psychopharmacology, 1995-01, Vol.9 Suppl 4, p.13-18 |
| issn | 0268-1315 1473-5857 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Accidents, Traffic - statistics & numerical data Antidepressive Agents, Tricyclic - adverse effects Automobile Driving Biological and medical sciences Cognition Disorders - chemically induced Depressive Disorder - drug therapy Dothiepin - adverse effects Drug toxicity and drugs side effects treatment Flicker Fusion - drug effects Fluvoxamine - adverse effects Humans Medical sciences Pharmacology. Drug treatments Psychomotor Performance - drug effects Reaction Time - drug effects Serotonin Uptake Inhibitors - adverse effects Time Factors Toxicity: nervous system and muscle |
| title | The behavioural toxicity of the selective serotonin reuptake inhibitors |
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