A Problem-Oriented Approach to Intestinal and Liver Disease after Marrow Transplantation
Bone marrow transplantation has become an accepted treatment for malignancy (particularly leukemia and lymphoma), aplastic anemia, and certain inborn errors of metabolism. Patients require intensive care because of chemoradiation therapy toxicity, a prolonged period of immunosuppression and thromboc...
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| Veröffentlicht in: | Journal of clinical gastroenterology 1988-08, Vol.10 (4), p.419-433 |
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| container_title | Journal of clinical gastroenterology |
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| creator | Wolford, John L McDonald, George B |
| description | Bone marrow transplantation has become an accepted treatment for malignancy (particularly leukemia and lymphoma), aplastic anemia, and certain inborn errors of metabolism. Patients require intensive care because of chemoradiation therapy toxicity, a prolonged period of immunosuppression and thrombocytopenia, graft-versus-host disease (GVHD), and the need for parenteral nutrition. Gastrointestinal and hepatic diseases are frequent post-transplant problems. They present with intractable nausea and vomiting, intestinal bleeding, diarrhea, esophageal complaints, abdominal pain, and hepatobiliary symptoms. Our clinical approach to complex transplant patients depends on the timing of signs and symptoms after marrow grafting and on the likelihood that specific disease processes are present. Each of these major problems is covered in this review. |
| doi_str_mv | 10.1097/00004836-198808000-00015 |
| format | Article |
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Patients require intensive care because of chemoradiation therapy toxicity, a prolonged period of immunosuppression and thrombocytopenia, graft-versus-host disease (GVHD), and the need for parenteral nutrition. Gastrointestinal and hepatic diseases are frequent post-transplant problems. They present with intractable nausea and vomiting, intestinal bleeding, diarrhea, esophageal complaints, abdominal pain, and hepatobiliary symptoms. Our clinical approach to complex transplant patients depends on the timing of signs and symptoms after marrow grafting and on the likelihood that specific disease processes are present. Each of these major problems is covered in this review.</description><identifier>ISSN: 0192-0790</identifier><identifier>EISSN: 1539-2031</identifier><identifier>DOI: 10.1097/00004836-198808000-00015</identifier><identifier>PMID: 3047222</identifier><identifier>CODEN: JCGADC</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Bone Marrow Transplantation ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Digestive System Diseases - etiology ; Esophageal Diseases - etiology ; Gastrointestinal Diseases - etiology ; Gastrointestinal Diseases - therapy ; Humans ; Liver Diseases - etiology ; Liver Diseases - pathology ; Medical sciences ; Postoperative Complications - etiology ; Postoperative Complications - therapy ; Terminology as Topic ; Transfusions. Complications. Transfusion reactions. 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Patients require intensive care because of chemoradiation therapy toxicity, a prolonged period of immunosuppression and thrombocytopenia, graft-versus-host disease (GVHD), and the need for parenteral nutrition. Gastrointestinal and hepatic diseases are frequent post-transplant problems. They present with intractable nausea and vomiting, intestinal bleeding, diarrhea, esophageal complaints, abdominal pain, and hepatobiliary symptoms. Our clinical approach to complex transplant patients depends on the timing of signs and symptoms after marrow grafting and on the likelihood that specific disease processes are present. Each of these major problems is covered in this review.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow Transplantation</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Digestive System Diseases - etiology</subject><subject>Esophageal Diseases - etiology</subject><subject>Gastrointestinal Diseases - etiology</subject><subject>Gastrointestinal Diseases - therapy</subject><subject>Humans</subject><subject>Liver Diseases - etiology</subject><subject>Liver Diseases - pathology</subject><subject>Medical sciences</subject><subject>Postoperative Complications - etiology</subject><subject>Postoperative Complications - therapy</subject><subject>Terminology as Topic</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><issn>0192-0790</issn><issn>1539-2031</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1LAzEQhoMotVZ_gpCD12iyyTbJsdSvQqUeKngLs9mErm53l2Rr8d-b2tqbgSHMzPsOzDMIYUZvGdXyjqYnFB8TppWiKmUkBctP0JDlXJOMcnaKhpTpjFCp6Tm6iPEjKSTnbIAGnAqZZdkQvU_wa2iL2q3JIlSu6V2JJ10XWrAr3Ld4liqxrxqoMTQlnldfLuD7KjqIDoPvU_YCIbRbvAzQxK6Gpoe-aptLdOahju7q8I_Q2-PDcvpM5oun2XQyJ1ZInRNuc-tzXzJlmeBceC0KCbYsqBLCp9WE5cpz54UY5xS045lgTo6tdzrpgY-Q2s-1oY0xOG-6UK0hfBtGzY6V-WNljqzML6tkvd5bu02xduXReICT-jeHPkQLtU8L2ioeZZLmWordGLGXbds68Yif9Wbrglk5qPuV-e9S_AeLn4DH</recordid><startdate>198808</startdate><enddate>198808</enddate><creator>Wolford, John L</creator><creator>McDonald, George B</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>198808</creationdate><title>A Problem-Oriented Approach to Intestinal and Liver Disease after Marrow Transplantation</title><author>Wolford, John L ; McDonald, George B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4795-3c5cf5fd18c14334f94b7acdb0844f8084c38f3ef44650a9e3241e76cfe9433a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow Transplantation</topic><topic>Bone marrow, stem cells transplantation. Graft versus host reaction</topic><topic>Digestive System Diseases - etiology</topic><topic>Esophageal Diseases - etiology</topic><topic>Gastrointestinal Diseases - etiology</topic><topic>Gastrointestinal Diseases - therapy</topic><topic>Humans</topic><topic>Liver Diseases - etiology</topic><topic>Liver Diseases - pathology</topic><topic>Medical sciences</topic><topic>Postoperative Complications - etiology</topic><topic>Postoperative Complications - therapy</topic><topic>Terminology as Topic</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wolford, John L</creatorcontrib><creatorcontrib>McDonald, George B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of clinical gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wolford, John L</au><au>McDonald, George B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Problem-Oriented Approach to Intestinal and Liver Disease after Marrow Transplantation</atitle><jtitle>Journal of clinical gastroenterology</jtitle><addtitle>J Clin Gastroenterol</addtitle><date>1988-08</date><risdate>1988</risdate><volume>10</volume><issue>4</issue><spage>419</spage><epage>433</epage><pages>419-433</pages><issn>0192-0790</issn><eissn>1539-2031</eissn><coden>JCGADC</coden><abstract>Bone marrow transplantation has become an accepted treatment for malignancy (particularly leukemia and lymphoma), aplastic anemia, and certain inborn errors of metabolism. Patients require intensive care because of chemoradiation therapy toxicity, a prolonged period of immunosuppression and thrombocytopenia, graft-versus-host disease (GVHD), and the need for parenteral nutrition. Gastrointestinal and hepatic diseases are frequent post-transplant problems. They present with intractable nausea and vomiting, intestinal bleeding, diarrhea, esophageal complaints, abdominal pain, and hepatobiliary symptoms. Our clinical approach to complex transplant patients depends on the timing of signs and symptoms after marrow grafting and on the likelihood that specific disease processes are present. Each of these major problems is covered in this review.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>3047222</pmid><doi>10.1097/00004836-198808000-00015</doi><tpages>15</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0192-0790 |
| ispartof | Journal of clinical gastroenterology, 1988-08, Vol.10 (4), p.419-433 |
| issn | 0192-0790 1539-2031 |
| language | eng |
| recordid | cdi_crossref_primary_10_1097_00004836_198808000_00015 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bone Marrow Transplantation Bone marrow, stem cells transplantation. Graft versus host reaction Digestive System Diseases - etiology Esophageal Diseases - etiology Gastrointestinal Diseases - etiology Gastrointestinal Diseases - therapy Humans Liver Diseases - etiology Liver Diseases - pathology Medical sciences Postoperative Complications - etiology Postoperative Complications - therapy Terminology as Topic Transfusions. Complications. Transfusion reactions. Cell and gene therapy |
| title | A Problem-Oriented Approach to Intestinal and Liver Disease after Marrow Transplantation |
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