A comparative review of the pharmacological and toxicological properties of disulfiram and calcium carbimide
Disulfiram and calcium carbimide are widely used alcohol deterrents. Their safe use, however, requires a knowledge of their pharmacology, toxicity, and interactions with alcohol and other drugs. The absorption, metabolism, and elimination of these compounds are described, and elimination of these co...
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| Veröffentlicht in: | Journal of clinical psychopharmacology 1981-01, Vol.1 (1), p.21-26 |
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| container_title | Journal of clinical psychopharmacology |
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| creator | Peachey, J E Brien, J F Roach, C A Loomis, C W |
| description | Disulfiram and calcium carbimide are widely used alcohol deterrents. Their safe use, however, requires a knowledge of their pharmacology, toxicity, and interactions with alcohol and other drugs. The absorption, metabolism, and elimination of these compounds are described, and elimination of these compounds are described, as is the mechanism of their reaction with ethanol. The effects and limitations of the interaction between ethanol and disulfiram and calcium carbimide are discussed. Four areas of concern regarding toxicity are discussed, including medical complications of the reactions with alcohol, toxicity associated with repeated doses of disulfiram or calcium carbimide, possible interactions with other drugs, and acetaldehyde-induce hepatotoxicity and cardiotoxicity. |
| doi_str_mv | 10.1097/00004714-198101000-00005 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0271-0749 |
| ispartof | Journal of clinical psychopharmacology, 1981-01, Vol.1 (1), p.21-26 |
| issn | 0271-0749 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Acetaldehyde - adverse effects Alcoholism - drug therapy Aldehyde Dehydrogenase Aldehyde Oxidoreductases - antagonists & inhibitors Cyanamide - adverse effects Cyanamide - metabolism Cyanamide - pharmacology Cyanides - pharmacology Disulfiram - adverse effects Disulfiram - metabolism Disulfiram - pharmacology Drug Interactions Ethanol - adverse effects Humans Intestinal Absorption |
| title | A comparative review of the pharmacological and toxicological properties of disulfiram and calcium carbimide |
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